1.Intramedullary Spinal Cord Metastasis: A Report of Two Cases and a Review of the Literature.
Yoon Kyeong OH ; Hee Chul PARK
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2001;19(4):353-358
Intramedullary spinal cord metastases (ISCM) account for only 3.4% of symptomatic metastases to the spinal cord. The survival of patients with ISCM is characteristically short, often no longer than 2 months, due to a rapid neurologic deterioration and the presence of widespread metastases, including metastases to the brain. We report two cases of ISCM arising from primary sphenoid sinus carcinoma and primary lung cancer along with a review of the literature. The case of ISCM from the primary sphenoid sinus is the third case of secondary syringomyelia due to ISCM in the world literature, and ISCM from the primary lung cancer is the first case reported in Korea. One case showed a slow progression of symptoms and a longer survival (26 months after the radiotherapy to the spine), and the other showed a rapid deterioration of symptoms with a shorter survival. More effective palliation can be achieved if the disease is diagnosed at an early stage when the neurologic deficits are still reversible.
Brain
;
Humans
;
Korea
;
Lung Neoplasms
;
Neoplasm Metastasis*
;
Neurologic Manifestations
;
Radiotherapy
;
Sphenoid Sinus
;
Spinal Cord*
;
Syringomyelia
2.Clinical Studies on Spondylolisthesis
Byeong Mun PARK ; In Hee CHUNG ; Hak Yoon OH
The Journal of the Korean Orthopaedic Association 1976;11(1):1-10
Spondylolisthesis is characterized by forward displacement of the vertebral body with bilateral defects of the partes interarticulares. Because the progression of slipping occurs in young adults, difficult problems are present in the treatment of this condition. Watkins(1953) described the technique of posterolateral fusion between transverse processes, which was accepted in the dynamics of spine motion. In this procedure, grafted bone is placed close to the center of axis of the spine motion and so, bony fusion is not affected by flexion motion but distracted by a Iateral shearing force. The role played by the Norton-Brown back brace is in the restriction of lateral bending. However it pormits somewhat flexion motion of the spine. It is suggested that early ambulation may be possible without the interference of bony union after the posterolateral fusion operation when this brace is applied instead of longterm cast immobilization. In clinical analyses and follow-up studies after operative treatments in 55 patients with spondylolisthesis, the following results were obtained: 1. 30 patients (54.6%) were distributed between 21 and 40 years of age. 2. Males (52.7%) were slightly more than females (47.3%). 3. Among clinical symptoms and signs, low back pain was most common (87.3%). Sciatica was present in 45.5% 4. Duration of symptoms at admission was variable. 5. 15 patients (27.3%) had a previous history of trauma. 6. 5th lumbar vertebra was most commonly involved (74.5%) followed by the 4th lumbar vertebra(23.6%). There was a case(1.9%) in which the 5th and 4th lumbar vertebrae were involved. 7. Degrees of slipping were divided into 4 grades (Grade I–IV) by Meyerdings method. Grade 1 was most common (72.2%), Grade II 22.2% and Grade III 5.6%. 8. In follow-up studies of the operative treatment, laminectomy & H-graft were satisfactory in 84.9% and posterolateral fuion in aII cases (13 patients). 9. Early ambulation was preferred without healng disturbance in a case in which the Norton-Brown back brace was applied after posteroIateraI fusion and also, other advantages were expected as follws: a) Elimination of prolonged cast immobiIization b) Financial aid c) Early return to work d) Mental comfort.
Braces
;
Early Ambulation
;
Female
;
Follow-Up Studies
;
Humans
;
Immobilization
;
Laminectomy
;
Low Back Pain
;
Lumbar Vertebrae
;
Male
;
Methods
;
Return to Work
;
Sciatica
;
Spine
;
Spondylolisthesis
;
Transplants
;
Young Adult
3.A Case of Severe Hypertension associated with Growth Hormone Therapy.
Nyeon HEO ; Chang Hee OH ; June HUH ; Phil Soo OH ; Hong Jin LEE ; Hae Sun YOON
Journal of Korean Society of Pediatric Endocrinology 2001;6(1):77-84
The use of recombinant DNA technology to produce human growth hormone has resulted in a marked increase in availability of Growth Hormone(GH) to treat short stature due to GH deficiency and other conditions, such as Turner syndrome, familial short stature, chronic renal insufficiency and intrauterine growth retardation (IUGR). But, the GH therapy may result in the adverse events such as sodium and water retention, pseudotumor cerebri, slipped capital femoral epiphysis, growth of nevi, recurrence of tumor. We experienced a case of severe hypertension associated with GH therapy in a 14-year-old male who presented high blood pressure up to 190/100 mmHg and normalized at 2-3 weeks after discontinuation of GH. Therefore, we think that the blood pressure should be carefully monitored during GH therapy.
Adolescent
;
Blood Pressure
;
DNA, Recombinant
;
Fetal Growth Retardation
;
Growth Hormone*
;
Human Growth Hormone
;
Humans
;
Hypertension*
;
Male
;
Nevus
;
Noonan Syndrome
;
Pseudotumor Cerebri
;
Recurrence
;
Renal Insufficiency, Chronic
;
Slipped Capital Femoral Epiphyses
;
Sodium
4.A Case of Progressive Zosteriform Macular Pigmented Lesion.
Oh Chan KWON ; Jong Kyu YANG ; Dou Hee YOON ; Tae Yoon KIM ; Hyung Ok KIM
Korean Journal of Dermatology 1998;36(3):456-459
Progressive zosteriform macular pigmented lesion(PZMPL) is a chronic pigmentary dermatosis similar to progressive cribriform and zosteriform hyperpigmentation(PCZH). This dermatosis described by Simoes in 1980 is characterized by a uniformly tanned macular pigmented lesion in a zosteriform distribution preceded by multiple pruritic macular pigmentation in a part of the dermatome for a period. PZMPL is not a fully understood disease entity but it is thought to be a variant of PCZH. It is differentiated from PCZH by accompanying pruritus as a prodromal symptom, a characteristic clinical course, and histological findings such as pigmentary incontinence. We report herein a case of PZMPL in a 17 year-old girl with the pigmentary skin lesion extending from the left forearm to the left chest along the Blaschkos line. The histological findings revealed increased melanin pigments in the basal layer and focal pigmentary incontinence in the upper dermis. To our knowledge, this case is the first report of PZMPL in korea thought to be the same case reported by Simoes.
Adolescent
;
Dermis
;
Female
;
Forearm
;
Humans
;
Korea
;
Melanins
;
Pigmentation
;
Prodromal Symptoms
;
Pruritus
;
Skin
;
Skin Diseases
;
Thorax
;
Triacetoneamine-N-Oxyl
5.Medullary carcinoma of the breast: Imaging findings characteristics vs histologic classification.
Chang Soo AHN ; Ki Keun OH ; Choon Sik YOON ; Woo Hee CHUNG ; Yong Hee LEE
Journal of the Korean Radiological Society 1993;29(5):1071-1079
It is well known that the medullary carcinoma of the breast is one of the special types of breast carcinoma with a good prognosis. At present, the medullary carcinoma of the breast is subclassified into 3 types: typical medullary, atypical medullary and nonmedullary carcinoma. Among them, the former has the best prognosis. We reviewed the film mammographic and ultrasonomammographic findings of 13 patients according to the reevaluated histopathologic diagnosis. Typical medullary carcinoma shows a well circumscribed mass with surrounding halo on film mammogram, and well defined mass with central intermediate echogenicity and peripheral low echogenicity and posterior acoustic enhancement on ultrasonomammogram. Atypical medullary carcinoma shows relatively well circumscribed mass with partial marginal obliteration on film mammogram, and irregular bordered mass with inhomogeneous echogenicity due to focal necrosis in the mass and associated findings of thick boundary, asymetrical lateral shadowing on ultrasonomammogram. Nonmedullary carcinoma shows lobulated mass with surrounding parenchymal distortion and skin thickening on film mammogram, and relatively well defined lobulating mass with surrounding parenchymal distortion and marked heterogeneous internal echogenicity on ultrasonomammogram. Therefore, differentiation between typical medullary carcinoma with good prognosis and atypical medulary or nonmedullary carcinoma with poor prognosis, may be possible by various diagnostic imaging modalities preoperatively. But further collective study shall be needed in near future.
Acoustics
;
Breast Neoplasms
;
Breast*
;
Carcinoma, Medullary*
;
Classification*
;
Diagnosis
;
Diagnostic Imaging
;
Humans
;
Necrosis
;
Prognosis
;
Shadowing (Histology)
;
Skin
6.A Case of Erythrodermic Form of Mycosis Fungoides.
Moo Kyu SUH ; Yeol Oh SUNG ; Ki Seong YOON ; Kyoung Yim HA ; Jung Ran KIM ; Yeon Hee OH ; Sam KWON
Korean Journal of Dermatology 1998;36(1):111-115
We report a case of an erythrodermic form of mycosis fungoides in a 68-year-old male, who showed generalized erythroderma with scales for 3 months. Lymphadenopathies in the inguinal and neck areas were present. Histopathological findings showed epidermotropism, perivascular atypical lymphocyte infilteration in the upper dermis, and dermatopathic lymphadenopathy in the inguinal lymph node. T cell markers were positively stained in the immunohistochemical study. These clinicopathological features were consistent with an erythrodermic form of mycosis fungoides(TNM IIl). The patient was treated with PUVA therapy and low dose chemotherapy.
Aged
;
Dermatitis, Exfoliative
;
Dermis
;
Drug Therapy
;
Humans
;
Lymph Nodes
;
Lymphatic Diseases
;
Lymphocytes
;
Male
;
Mycosis Fungoides*
;
Neck
;
PUVA Therapy
;
Weights and Measures
7.A Case of Duplication o f the Ileum.
Sang Kenn OH ; Sook Young LEE ; Yoon Oh PARK ; Mi Sook PARK ; Young Chul LEE ; Hee Dae PARK
Journal of the Korean Pediatric Society 1987;30(12):1446-1451
No abstract available.
Ileum*
8.Systemic Interferon-Gamma Therapy for Atopic Dermatitis.
Sun Hee JUNG ; Su Kyeong OH ; Un Ki YOON ; Ji Sub OH
Pediatric Allergy and Respiratory Disease 1999;9(2):200-209
PURPOSE: Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and an immunologic profile consistent with allergic disease. It is associated with increased eosinophil and IgE level and decreased INF-gamma production. We describe the result of a treatment with INF-gammaand assess the clinical, immunologic, and laboratory data of 12 patients with atopic dermatitis. METHODS: Twelve patients were treated for 12 weeks with 2x106 units/m2 INF-gamma by subcutaneous injection. General hematologic tests were done, and total eosinophil counts, eosinophil fractions, neutrophil fractions, and IgE levels were measured before the treatment, 2 weeks after the treatment, 12 weeks after the treatment serially. We also followed up the patients for 12 weeks after discontinuing INF-gammatherapy. RESULTS: All patients showed clinically significant improvement after 12 weeks of the systemic INF-gammatherapy. There was no clinical aggravation during the therapy period and the follow-up 4 weeks without the therapy. But the recurrence rate in the 12 weeks after discontinuing the therapy was about 40%. Eosinophil counts and eosinophil fractions were significantly decreased after the therapy. And, eosinophil counts and eosinophil fractions were increased in clinically aggravated patients during the 12 weeks of off-therapy. CONCLUSION: We conclude that INF-gammais an effective therapy in atopic dermatitis without significant side effects. The eosinophil counts and eosinophil fractions were decreased during the INF-gamma therapy, and increased in clinically aggravated patients after the off-therapy. There was no aggravation during the therapy. But 5 patients were clinically aggravated during the 12 weeks of off-therapy. Further studies for a long-term maintenance therapy and its side effect might be needed in chronic atopic dermatitis.
Dermatitis, Atopic*
;
Eosinophils
;
Follow-Up Studies
;
Hematologic Tests
;
Humans
;
Immunoglobulin E
;
Injections, Subcutaneous
;
Interferon-gamma*
;
Neutrophils
;
Pruritus
;
Recurrence
;
Skin Diseases
9.TGF - beta Type II Receptor Anomaly and of Its Functional Restoration in Osteosarcoma Cell Lines.
Kwan Hee LEE ; Sang Soo OH ; Young Deog CHA ; Suk Myun KO ; In Suk OH ; Joung Yoon LEE ; Sung Jin KIM
The Journal of the Korean Orthopaedic Association 1998;33(3):914-919
TGF-p receptor mutation is now considered as one of the carcinogenic process of many tumors. To evaluate whether there is an abnormality in TGF-p type II receptor in osteosarcoma cell lines, we performed Northern analysis, cross-linking assay, luciferase activity and TGF-p growth inhibition assay in four osteosarcoma cell lines: G292, U202, HOS and SaOS. We also transfected the tumor cells with normal TGF-p type II receptor sequence to find if there is a possibility of gene therapy in osteosarcoma. In Northern analysis, Type II receptor expressions were decreased at SaOS, U202 and HOS cell lines. In cross-linking assay, all four cell lines didnt show type II receptor at their cell surface. The growth of these tumor cells were not suppressed by TGF-p. From these findings, we concluded that the normal production of TGF-p type II receptor was impaired in osteosarcoma. The transfection of these tumor cells with normal type II receptor sequence restored growth inhibition by TGF-p. This means even though TGF-p type II receptor is abnormal in osteosarcoma, we can restore its function by transfection of normal sequence. We think that the TGF-p type Il receptor gene therapy can be one of the treatment method for osteosarcoma in the future.
Cell Line*
;
Genetic Therapy
;
Luciferases
;
Osteosarcoma*
;
Transfection
10.Adenosis Tumor of the Breast: A Case Report.
Woo Hee JUNG ; Ki Keun OH ; Pyeong Ho YOON ; Mi Kyeong JUNG ; Jung Yeon SHIM
Journal of the Korean Radiological Society 1995;32(5):831-823
Adenosis tumor is a ra re tumor of the breast and primarily consists of adenosis. Authors report a case of surgically proved adenosis tumor in a 31-year-old woman. Mammogram showed a Iobulated, well-circumscribed mass with several surrounding radiolucent halos. In the center of the mass several linear radiolucent densities were seen with the appearance of a conglomerated well-circumscribed mass such as fibroadenoma. These linear radiolucent densities were consistent with the fat between the fibrous sclerosis in pathologic specimen. Ultrasonogram showed a well-circumscribed mass with homogeneous low echogenicity, partial posterior enhancement, and bilateral acoustic shadowings.
Acoustics
;
Adult
;
Breast*
;
Female
;
Fibroadenoma
;
Humans
;
Sclerosis
;
Shadowing (Histology)
;
Ultrasonography