Cutaneous manifestations of sarcoidosis are highly variable and can be devided into the specific lesions which reveal noncaseating granuloma and the nonspecific lesio is which are referred to as cutaneous changes. Among speciific lesions, annular lesions may be foimied from coalescing papular lesions that may clear centrally and elevate peripherally. We report a case of sarcoidosis with multiple annular lesions on the face in a 33-year-old female who had systemic involvements in the intrathoracic organs and eyes. The main histopathologir. findings were well-demarcated islands of epitheloid cells with a few giant cells in the dermis. In addition, a slight admixfure of lymphoid cells was present at the margins of the epitheloid cell granulomas. Complete regression of t!he skin lesions was obtained with systemic cortiocosteroid therapy and no recurrence has been found for 2 1/2years.
Adult ; Dermis ; Female ; Giant Cells ; Granuloma ; Humans ; Islands ; Lymphocytes ; Recurrence ; Sarcoidosis* ; Skin

No abstract available.
Animals ; Horns* ; Pregnancy*

No abstract available.
Animals ; Horns* ; Pregnancy*

Urethrocutaneous fistula is the most common complication of hypospadias surgery, Many techniques have been tried to prevent urethrocutaneous fistula. We introduce the technique of neourethral coverage using adjacent subcutaneous tissue or a dorsal pedicled subcutaneous flap in hypospadias repair. This method was used in a series of 25 cases between April 1996 and April 1997. We experienced only one urethrocutaneous fistula. The additional coverage of the neourethra with the subcutaneous tissue achieves the goal of non-overlapping suture lines and allows for increased vascularity. So, this technique appears to be effective in preventing urethrocutaneous fistula in hypospadias repair.
Female ; Fistula* ; Hypospadias ; Male ; Subcutaneous Tissue* ; Sutures

We report a 36-year-old male with the bilateral visual field defect following LASIK was observed. Preoperatively, patient had high myopia(right. -7.25 0.75x18, left. -7.5-0.5x12), normal intraocular pressure(IOP)(right/left: 16/14 mmHg), normal visual field(Humphrey 30-2 visual field)and revealed the tilted discs with symetric optic nerve head cupping(cup-to-disc ratio, 0.70), parapapillary atrophy. Bilateral LASIK keratorefractive surgery was on the same day and intraoperative complication was not noted. After the first operative visit day, examination revealed uncorreted visual acuity right 0.8 and left 0.6 but scotoma was reported. Three months later, Humphrey 30-2 visual field revealed a near-superior altitudinal defect in the right eye and nasal side visual field defect in the left eye. Best corrected visual acuity was 1.0 in the right eye, 0.8 in the left eye. Repeated visual fields over a 11-month period postoperatively showed stability of the defect, with IOP of 12 mmHg to 15 mmHg in each eye. We considered LASIK uses a microkeratome vaccum ring to make a corneal flap, transient elevation of IOP alters the microcirculation of optic nerve head and may have precipitated visual field defect.
Adult ; Atrophy ; Humans ; Intraoperative Complications ; Keratomileusis, Laser In Situ ; Male ; Microcirculation ; Optic Disk ; Scotoma ; Visual Acuity ; Visual Fields*

Kaposi's sarcoma is a neoplasm of multifocal origin which manifest primarily as vascular nodules in the skin and other organs. We report a case of Kaposis sarcoma of classic type in a 17-year-old boy, who had a 4 x 5cm sized, dusky erythematous plaque with multiple spots of acupuncture on the left foot for 1 year. Histopathologic examination showed dilated, bizarre-shaped vessels, ndothelial cell proliferation, and spindle cell formation with vascular slits throughout the dermis. He was treated with 3000 rads of radiation(300 rad per day for l0 successive days). Six months after radiotherapy, gross findings were much improved and histopathologic findings showed only fibrosismc hemosiderin deposits in the dermis.
Acupuncture ; Adolescent ; Cell Proliferation ; Dermis ; Foot ; Hemosiderin ; Humans ; Male ; Radiotherapy* ; Sarcoma, Kaposi* ; Skin

Air pollution does harm to the respiratory tracts. Fine particulate matter (PM(2.5)) attacks the lung directly passing through mucosal ciliary clearance, causes new-onset asthma, or exacerbates asthma symptoms in children. Oxidative stresses, immunologic changes, allergic sensitization, and epigenetic modification are associated with bronchial asthma. Furthermore, it causes respiratory tract infection and lung function decline. We have to protect the children who are more vulnerable to PM(2.5) than adults. We will investigate individual exposure, influences by the components of air pollution, and genetic susceptibility.
Adult ; Air Pollution ; Asthma ; Child ; Epigenomics ; Genetic Predisposition to Disease ; Humans ; Lung ; Oxidative Stress ; Particulate Matter ; Respiratory System ; Respiratory Tract Infections

OBJECTIVES: Tree pollen causes allergic rhinitis and asthma. We investigated children who diagnosed as rhinitis or asthma, living in Busan, for tree allergen sensitization, component allergen, oral allergy syndrome, and the relationship between pollen counts and allergen sensitization.METHODS: Pollen were collected in Busan, from January 1 to December 31, 2017, using a Rotorod sampler and enumerated using a microscope. We conducted a study of children with rhinitis or asthma at Busan St. Mary's Hospital in 2017, administered an ISAAC questionnaire, and an oral allergy syndrome survey. Serum specific Ig E tests were performed.RESULTS: Among the 57 patients, the mean age was 9.3 years. The pollen counts in decreasing order were as follows: pine, alder, oak, juniper, beech, ginkgo, and birch. For sensitization, birch and alder 35.1%, Japanese cedar 19.3%, juniper 17.5%, pine 10.5%, and Japanese cypress 8.2%. The component Ig E was tested in 27 patients. Bet v 1 had a high correlation with birch, alder, and peach. Bet v 2 showed a statistically significant correlation with all tree pollen except cypress. Bet v 4 did not have any apparent correlation. Bet v 6 had the same pattern as Bet v 2, but correlation coefficient was higher than that of Bet v 2. Oral allergy syndrome was noted in 7 patients, including peach, peanut, apple, tomato, kiwi, and sesame.CONCLUSIONS: Alder and juniper are clinically important tree pollens in Busan. These pollens cause sensitization to birch and Japanese cedar by cross-reaction.
Alnus ; Arachis ; Asian Continental Ancestry Group ; Asthma ; Betula ; Busan ; Child ; Cryptomeria ; Cupressus ; Fagus ; Ginkgo biloba ; Humans ; Hypersensitivity ; Juniperus ; Lycopersicon esculentum ; Pollen ; Prunus persica ; Rhinitis ; Rhinitis, Allergic ; Sesamum ; Trees

We experienced a rare case of a 6-year-old boy who was suspected of having lipid transfer protein (LTP) syndrome; the patient was diagnosed with LTP syndrome using the ImmunoCAP/ImmunoCAP Immuno Solid-phase Allergen Chip (ISAC) test. LTP syndrome affects patients who are already sensitized to pollens with signs and symptoms of allergic rhinitis with or without bronchial asthma.Its severity is closely associated with the geographical location as well as the level, nature, and duration of the allergen exposure in a susceptible individual with or without cofactors, such as exercise, alcohol, chemicals, or nonsteroidal anti-inflammatory drug. Patients with LTP syndrome may present with diverse manifestations ranging from local symptoms, such as mild contact urticaria, oral allergy syndrome, or gastrointestinal problems, to anaphylaxis and even anaphylactic shock. Our case highlights the usefulness of the ImmunoCAP/ImmunoCAP ISAC test in establishing a diagnosis of LTP syndrome.

Lipid transfer protein (LTP) is a widely cross-reacting allergen in vegetables, fruits, nuts, or cereals. The amino acids sequence of LTP shows high structural similarity in various foods and thus acts as a pan-allergen. LTP syndrome is a new term for the pattern of clinical symptoms and natural course of allergy caused by LTP antigens. It is frequently reported by peaches mainly in the Mediterranean region, and reports in East Asia are rare. Therefore, this case report introduces a 36-year-old female Asian who experienced recurrent anaphylaxis and oral allergy syndrome, and finally diagnosed with LTP syndrome.