The routine closed patch tests were performe0 with 41 kinds of domestic soaps, detergents, cosm etics and topical medicaments (incIuding a adhesive plaster) on the intact skin of the back of 100 adult males without any dermatoses, to evaluate their side effects on the skin. 1, None of the materials showed no positive reaction, 2, The over all positive reactions were observed in 21.l% of my subjects, including a 1+reacti ons in,l6,4% and a 2+or 3, In 4.7% 3, In 12 kinds of soaps, Positive reaction wer observed in 19-33% positive of my subjects (average Z7.8%) 4, In 4 kinds of detergents, positive reations were observed in 6-19% of my subjects (average 9,7%), in which the highest reaction rate revealed was IVonderful of Dongsan fats and oils co.. 5. The positive reactiors in 3 kinds of toothpastes were observed in 37-61% of my subjects (average 50.7%). 6. The positive reactions to the adhesive plaster were observed in 25% of my subjects. Arnong 17 kinds of topial medicaments, positive reaction rates above 10 shown were Aroos oirtment of Sarn-A phaxmaceutical co. (49%), PM spirit of Kyungnam pharmaceutical co. (16%), Periio ointment of Namgang pharmaceutical co. (13%), Badional-Gel of Hanil pharm-aceutcal co. (10%) and Antiphlamine of Yuhan corporation (10%). 8. In 4 kinds of cosmetic creams, all showed higher positive reaction rates, i.e, "Masan Joongang cream of Yeinvonlang No I, 41%;No.2, 35%;N0.3, 32% and E.mong cream" of Daido phanna-ceutical co,44%.
Adhesives ; Adult ; Detergents ; Fats ; Gyeongsangnam-do ; Humans ; Male ; Oils ; Patch Tests ; Skin ; Skin Diseases ; Soaps* ; Toothpastes

Fifty-one cases of various warts were treated with 1-cbloro-2,4-dmitrobenzene (DNCB), and divided these warts into two groups by the method of treatment. The first group was treated by challenge on normal skin a,fter sensitization and the second group was treated by challenge on wart lesion after sensitization. The number of first group was 27 consisted of 13 of verruca vulgaris, 12 of verruca plana and 2 of condyloma acuminatum. The number of second group was 24 consisted of 10 of verruca vulgaris, 11 of verruca plana and R of verruca plantaris. The results are summarized as follows; 1. Thirty-one of all 51 cases (60. 7%) were cured. 2. Fifteen of 27 cases (55.5%) were cured in first group. 3. Sixteen of 24 cases (66. 6%) were cured in second group. 4. All 3 cases of verruca planaris were cured in second group. 5. Eight cases were cured only by sensitization and consisted of 6 of verruca plana and of verruca vulgaris. 6. There was no significant difference in cure rates of warts between the group within 2 years of duration and the group over 2 years of duration. 7. There were no severe adverse reactions.
Dinitrochlorobenzene* ; Immunotherapy* ; Skin ; Warts*

A typical case of lichen amyloidosis is reported. This case is considered to be the first one in Korea. Intralesional injection of prednisolone proved to be effective in this case. The etiologic and therapeutic aspects of this disease are discussed.
Amyloidosis* ; Injections, Intralesional ; Korea ; Lichens* ; Prednisolone

No abstract available.
Mast Cells* ; Skin Diseases*

Five cases of erythema dyschromicum perstans which seem to be the first cases in Korea are described. They are healthy subjects with moderately pigmented skin. Numerous gray-blue macules are seen on the covered part of the body in two patients, but dark brownish macules in other three patients. Histologic findings reveal the characteristic features of hydropic degeneration of the basal cell layer of the epidermis, perivascular infiltrates of lymphocytes and histiocytes and melanin-laden macrophages in the corium in four patients, however, merely pigmentary incontinence into the corium in one patient. We think that there are some problems in cases which show the chracteristic features of erythema dyschromicum perstans histologically but do not have peculiar clinical features, e.g. color of the lesion, especially in Oriental. In this respect, though there may be down for much discussion in three cases which have not typical color of the lesion, we report these cases with typical two cases under the name of erythema dyschromium perstans in order to accumulate more knowledge of these problems
Dermis ; Epidermis ; Erythema* ; Histiocytes ; Humans ; Korea ; Lymphocytes ; Macrophages ; Skin

Suction is a useful tool for separation of epidermis from dermis in vivo. With appropriate suction pressures and durations applied, cellular damage of the separated epidermis can reduce, This study was performed to examine the appropriste suction pressures and durations in the lhsional and normal skin of four vitiligo patients who wanted to take epidermal autograft. The suction pressures and durations for making the blisters of similar morphology were different according to person. Microscopic changes in the blisters of similar morphology were not very different, and suction of 200 to 250 mmHg for 2 to 3 hours with a 2cm diametered suction cup was considered to be acceptable. Obvious damage to keratinocytes and diminish of melanacyte number were observed with much more powerful and longer suction such as suction of 350 to 400 mmHg for 3 to 4 hours. The level of dermo-epidermal separation was between basal cell membrane.
Autografts ; Blister ; Cell Membrane ; Dermis* ; Epidermis* ; Humans ; Keratinocytes ; Skin ; Suction* ; Vitiligo*

A case of syringoma with unusual distribution in a young healthy woman is reported. Physical examination revealed numerous angular or lichenoid papules, varing from skin color to light brown in hue, on the anterior aspect of the neck, upper chest, breast, sternal area, inframammary area and abdomen with grouping tendency. Some papules had fine scales on their surface. The histologic findings were those of charateristic features of syringoma.
Abdomen ; Breast ; Female ; Humans ; Neck ; Physical Examination ; Skin ; Syringoma* ; Thorax ; Weights and Measures

These studies were undertaken to evaluate the morphological development of the epidermis, hair, sebaceous gland, eccrine sweat gland and basement membrane in the skin of the Korean fetuses. Nineteen fetuses, 4 to 28 weeks of age, ranging in size from 4 to 230mm crown-rump length, obtained from healthy Korean mothers, were used in these studies and histological observation was done in the different fetal weeks and in the various parts of .the body such as face, perioral, scalp, axilla, abdomen, palm and sole. The results are as follows: 1) At 4-5 weeks of fetal age, the epidermis consists of a single layer of undifferentiated cells and by the 6th week it becomes two-layered; the periderm and the stratum germinativum. At 12-13 weeks, the germinative layer proliferates in a centrifugal direction to form a stratum intermedium and also proliferates in a centripetal direction, giving rise to clusters of cells that grow into the subjacent dermis, to form prhair germs and eccrine sweat gIand germs. Keratohyaline granules first make an appearance at 20th week and the stratum granulosum appears at 28 weeks of fetal life. From 20th week onward the periderm gradually disappears and is replaced by a stratum corneum at 28 weeks.
Abdomen ; Axilla ; Basement Membrane* ; Crown-Rump Length ; Dermis ; Epidermis* ; Fetus ; Gestational Age ; Hair* ; Humans ; Mothers ; Scalp ; Sebaceous Glands* ; Skin* ; Sweat Glands* ; Sweat*

Lesional and normal skins in 10 patients of fixed drug eruption were studied. Number and vertical distance of rete ridges were measured in H & E stained specimens. Amount of free melanin and number of melanocytes were counted in dopa stained epidermal sheets. According to the number of recurrence, activity and number of melanocytes see med to be changed. The lesions of a few recurrence showed only active melano cytes, however, those of frequent recurrenoe increased number of melanocytes with marked elongation of rete ridges. It is supposed that the numerical increase of melanocytes were from the elongation of rete redges.
Dihydroxyphenylalanine ; Drug Eruptions* ; Humans ; Melanins ; Melanocytes* ; Recurrence ; Skin

HLA-A, B, C and HLA-DR are very important in the regulation of immune response and of transplant success or failure, but there have been a few reports about F3I A expression in melanocyt.es, a minor population of cpidermal cells. In the treatment of stable or segmental vitiligo, allogeneic melanocytes graft could t)e potentially useful if rejection does not. occur. The aim of this study was to examine the expression of HI.A-A, B, C and HI.A-DR in cultured hurnan melanocytes with and without. stimulation by INF-r and suction blister fliid. All strains of cultured me- lanocytes expressed HLA-A, B, C regardless of stmulation, but HLA-DR was expressed only following stimulation of INI-r. HLA expression in me]anocytes appears to be similar to that in keratinocytes.
Blister* ; HLA-A Antigens ; HLA-DR Antigens* ; Humans* ; Keratinocytes ; Melanocytes* ; Suction* ; Transplants ; Vitiligo