1.Spouse concordance of coronary risk factors and the effect of marriage duration.
Hee Jeong KOH ; Taiwoo YOO ; Hong Soo LEE
Journal of the Korean Academy of Family Medicine 2000;21(2):163-174
BACKGROUND: Familial aggregation of coronary risk factors is well known, which are hypertension, hyperlipidemia, diabetes mellitus, and obesity. However inter-spouse relation of the risk factors has remained controversial. As spouses are not blood-related, any risk factor relation that exist probably may not reflect genetic factors, but the environmental factors to which the couple is exposed. Moreover, the effect of assortative marriage should be considered. This study is designed to identify inter-spouse relation of coronary risk factors and to document the effects of marriage duration to spouse concordance. METHODS: From May 1995 to March. 1999, we enrolled 1,859 couples who had visited the Health Promotion Center at Seoul National University Hospital. We analysed inter-spouse correlation of body mass index, blood pressure, glucose, serum lipid factors, uric acid, smoking, alcohol drinking, and stress known as coronary risk factors. The correlation coefficients were compared according to marriage duration. RESULTS: There was statistically significant spouse concordance for all risk factors with the exception of smoking. The correlation coefficients of blood pressure, total cholesterol, and triglyceride increased with marriage duration but troughed at 30-39 years of marriage. Those of body mass index and glucose peaked at early and late marriage duration. Those of HDL-cholesterol and uric acid was relatively fixed throughout marriage. CONCLUSION: The presence of significant inter-spouse correlation for most of the coronary risk factors reflect the influence of assortative marriage and environmental factors on spouse concordance. If a spouse has many cardiovascular risk factors, partner should be evaluated for risk factors.
Alcohol Drinking
;
Blood Pressure
;
Body Mass Index
;
Cardiovascular Diseases
;
Cholesterol
;
Diabetes Mellitus
;
Family Characteristics
;
Glucose
;
Health Promotion
;
Humans
;
Hyperlipidemias
;
Hypertension
;
Marriage*
;
Obesity
;
Risk Factors*
;
Seoul
;
Smoke
;
Smoking
;
Spouses*
;
Triglycerides
;
Uric Acid
2.Early diagnosis of pneumocystis carinii pneumonia by calcofluor white stain in bronchoalveolar lavage fluid.
Jae Hoon SONG ; Jung Eun CHOI ; Yong Sun JOO ; Yoon Suk KOH ; Yang Soo KIM ; Bin YOO ; Yung Joo CHO ; Won Dong KIM ; Yoo Kyum KIM
Korean Journal of Infectious Diseases 1993;25(2):125-130
No abstract available.
Bronchoalveolar Lavage Fluid*
;
Bronchoalveolar Lavage*
;
Early Diagnosis*
;
Pneumocystis carinii*
;
Pneumocystis*
;
Pneumonia, Pneumocystis*
3.Expression of WT1 Gene in Childhood Acute Leukemia.
Hyoung Soo CHOI ; Sang Hyeok KOH ; Keon Hee YOO ; Pil Sang JANG ; Hee Young SHIN ; Hyo Seop AHN
Korean Journal of Pediatric Hematology-Oncology 2000;7(1):92-104
PURPOSE: Recently Wilms tumor gene (WT1) transcripts have been detected in leukemia regardless of the disease subtype and the specific DNA markers suggesting that WT1 gene might be a useful panleukemic marker for monitoring minimal residual disease (MRD). This study was performed to investigate the expression of WT1 gene by a quantitative methods and to find the prognostic value of WT1 gene in childhood acute leukemia. METHODS: From the mononuclear cells isolated from bone marrow aspirates and peripheral bloods of 22 childhood acute and chronic leukemia patients, mRNA were extracted for the reverse transcriptase-polymerase chain reactions (RT-PCR). Relative levels of WT1 gene expression was calculated by using the value in K562 cell line to be 1.00 as a positive control. RESULTS: The sensitivity of detection of MRD with WT1 primers was 10 4 and comparable to that of bcr/abl expression in K562 cells and a patient with CML in blast crisis. WT1 gene expression was detected in 17 of 22 (77%) patients; 9/10 of acute lymphoblastic leukemia (ALL), 6/10 acute myelogenous leukemia (AML), 1 acute mixed lineage leukemia (AMLL) and 1 chronic myelogenous leukemia (CML) in blast crisis. In 4 AML patients who received autologous peripheral blood stem cell transplantation (PBSCT), two patients relapsed after reappearance of WT1 gene expression in bone marrow aspirates and the remaining two were in complete remission without expression of WT1 gene. CONCLUSION: These results show that WT1 gene expression is frequently noted in childhood acute leukemia and can be a useful sensitive marker for the detection of MRD comparable to bcr/abl transcripts. WT1 gene can be used as a panleukemic marker for the MRD monitoring for the evaluation of the remission status and in predicting early relapse in children with acute leukemia in the molecular levels. It may also be a useful tool for the detection of leukemic cell contamination in the process of peripheral blood stem cell transplantation.
Blast Crisis
;
Bone Marrow
;
Cell Line
;
Child
;
Gene Expression
;
Genetic Markers
;
Humans
;
K562 Cells
;
Leukemia*
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Leukemia, Myeloid, Acute
;
Neoplasm, Residual
;
Peripheral Blood Stem Cell Transplantation
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Recurrence
;
RNA, Messenger
;
Wilms Tumor
4.5-fluorouracil and low dose leucovorin in advanced colorectal carcinoma.
Ho Yeong LIM ; Hyun Cheol CHUNG ; Jin Hyuk CHOI ; Nae Chun YOO ; Dong Lip KIM ; Eun Hee KOH ; Joo Hang KIM ; Jae Kyung ROH ; Byung Soo KIM
Journal of the Korean Cancer Association 1991;23(3):563-570
No abstract available.
Colorectal Neoplasms*
;
Fluorouracil*
;
Leucovorin*
5.Efficacy of ONDANSETRON(GR38032F) for the control of cisplatin induced nausea and vomiting in patients with advanced malignancies.
Jae Kyung ROH ; Nae Chun YOO ; Jin Hyuk CHOI ; Hyun Cheol CHUNG ; Ho Young LIM ; Eun Hee KOH ; Joo Hang KIM ; Byung Soo KIM
Journal of the Korean Cancer Association 1991;23(4):814-820
No abstract available.
Cisplatin*
;
Humans
;
Nausea*
;
Vomiting*
6.Immune Response to Hepatitis B Vaccination for Adults with Isolated Antibody to Hepatitis B Core Antigen in the Hepatitis B Endemic Area.
Hee Jeong KOH ; Ji Ho CHOI ; Sung Ryul KIM ; Hong Soo LEE ; Heyn Eun KANG ; Tai Woo YOO
Journal of the Korean Academy of Family Medicine 2004;25(5):392-396
BACKGROUND: Korea is a highly prevalent area of isolated anti-HBc with a rate of 15%, but there is neither vaccination nor management guideline agreed. To know the management for Hepatitis B Vaccination for adults with isolated anti-HBc, we investigated immune response to hepatitis B vaccination in adults with isolated anti-HBc. METHODS: The 23 adults with persistent isolated anti-HBc, who visited a health promotion center from Dec. 1998 to Aug. 1999, were vaccinated with Hepavax?-B by the standard schedule (0, 1, 6 month) and anti-HBs titers were measured 1 month after 1st and 3rd vaccinations (1, 7 month). RESULTS: After the 1st vaccination, 18 (78.26%) developed anti-HBs seroconversion. Among them, 4 (17.39%) had titers of 10~49 mIU/ml, 8 (34.78%) 50~99 mIU/ml, and 6 (26.09%) more than 100 mIU/ml. All non-responders after the 1st vaccination remained as such even with 3 doses of complete vaccination. The majority of seroconverted group did not show more anti-HBs response with further vaccination. CONCLUSIONS: Since none of adults with isolated anti-HBc had a primary response, which indicated few false positive results. Therefore they should be excluded on vaccination programs in Korea. To differentiate between immunity and occult infections, a single dose of vaccine with a follow-up anti-HBs test is preferable for adults with isolated anti-HBc. If the test shows a seroconversion it would indicate protective immunity, if not, then occult infection may be suspected.
Adult*
;
Appointments and Schedules
;
Follow-Up Studies
;
Health Promotion
;
Hepatitis B Core Antigens*
;
Hepatitis B*
;
Humans
;
Korea
;
Vaccination*
7.A Study of Patients with Spasm of the Near Reflex.
Yoo Ri YANG ; Jae Woong KOH ; Nam Young CHOI ; Soo Chul PARK
Journal of the Korean Ophthalmological Society 2006;47(10):1630-1637
PURPOSE: To determine changes in the degree of pseudomyopia and convergence in patients with spasm of the near reflex. METHODS: In 5 patients with spasm of the near reflex, we checked following: UCVA/BCVA, the degree of pseudomyopia revealed through manifest and cycloplegic refraction tests, pupil size, limitation of EOM, the amount of convergence defined by the alternate prism cover test, and slit lamp and funduscopic exams. RESULTS: Of the 5 patients with spasm of near reflex, 3 had accommodative spasm alone and 2 had accommodative spasm, convergence spasm and miosis. The patients' degrees of pseudomyopia and convergence were -8.0D and 14PD on the average. which disappeared after an average of 10.8 months but recurred in 1 of the 3 patients with accommodative spasm. As for spasm of the near reflex, 1 patient showed improvement in convergence but worsening pseudomyopia during the follow-up period, and another patient showed recurrence. CONCLUSIONS: The most common clinical feature of spasm of the near reflex is accommodative spasm. Patients with accommodative spasm alone showed better prognosis among all patients with spasm of the near reflex in terms of recurrence and the disease course.
Follow-Up Studies
;
Humans
;
Miosis
;
Prognosis
;
Pupil
;
Recurrence
;
Reflex*
;
Spasm*
8.A Case of Neurilemmoma of the Chest Wall.
Yong Ho KOH ; Myoung Im KIM ; Min Soo HAN ; Jee Hong YOO ; Hong Mo KANG
Tuberculosis and Respiratory Diseases 1999;46(4):580-585
Neurilemmoma is a benign nerve sheath tumor derived from Schwann cells and occurs in the head, neck, flexor regions of the extremities, posterior mediastinum but extremely rare in the chest wall. They occur at all ages but are most common in persons between the ages of 20 and 50 years and develop spontaneously or possible as a result of trauma or irritation. The diagnosis of a neurilemmoma is confirmed histologically by the findings of Verocay bodies, Antoni A and B tissue patterns and the presence of S-100 protein. We experienced a case of chest wall neurilemmoma which was treated by local excision and report it with a brief review of the literature.
Diagnosis
;
Extremities
;
Head
;
Humans
;
Mediastinum
;
Neck
;
Neurilemmoma*
;
S100 Proteins
;
Schwann Cells
;
Thoracic Wall*
;
Thorax*
9.A Case of Neurilemmoma of the Chest Wall.
Yong Ho KOH ; Myoung Im KIM ; Min Soo HAN ; Jee Hong YOO ; Hong Mo KANG
Tuberculosis and Respiratory Diseases 1999;46(4):580-585
Neurilemmoma is a benign nerve sheath tumor derived from Schwann cells and occurs in the head, neck, flexor regions of the extremities, posterior mediastinum but extremely rare in the chest wall. They occur at all ages but are most common in persons between the ages of 20 and 50 years and develop spontaneously or possible as a result of trauma or irritation. The diagnosis of a neurilemmoma is confirmed histologically by the findings of Verocay bodies, Antoni A and B tissue patterns and the presence of S-100 protein. We experienced a case of chest wall neurilemmoma which was treated by local excision and report it with a brief review of the literature.
Diagnosis
;
Extremities
;
Head
;
Humans
;
Mediastinum
;
Neck
;
Neurilemmoma*
;
S100 Proteins
;
Schwann Cells
;
Thoracic Wall*
;
Thorax*
10.A Clinical Study of Pulmonary Tuberculosis in Diabetics.
In Kyung JEONG ; Jee Hong YOO ; Seon Mee LEE ; Kwan Pyo KOH ; Min Soo HAN ; Hong Mo KANG
Tuberculosis and Respiratory Diseases 1998;45(4):705-713
BACKGROUND: An association between diabetes and tuberculosis has long ken implied. The severity of diabetes appears to correlate with the degree of tuberculous activity. METHODS: A retrospective chart review of 82 patients with active pulmonary tuberculosis in diabetics(DMTB) and 83 patients with active pulmonary tuberculosis in nondiabetios (Non-DMTB) admitted to the Kyung Hee Medical Center between January 1995 and December 1996 was undertaken. RESULTS: The sex ratio of DMTB was 58 : 24, and that of Non-DMTB was 62 : 21. Male patients predominated in both groups. The highest incidence of DMIB was 6th and 7th decades and that of Non-DMTB was 3rd and 4th decades. In case which the tuberculosis developed after diagnosis of diabetes, the prevalence of pulmonary tuberculosis was the highest in diabetes for 5 -10 years. On chest X-ray findings, the moderate advanced tuberculosis cases were the most common (60.9% in DMTB and 50.6% in Non-DMTB). There was no relation between the degree of tuberculosis activity on chest x-ray(minimal, moderata awl far advanced tuberculosis) and presence of diabetes. The incidence of lower lung field tuberculosis in DMTB was significantly higher than Non-DMTB(p<0.05). The multiple lobe involvement was the predominant chest roentgenograpflc finding in both groups. There was no significant difference of treatment response between DMTB and Non-DMTB. There was no relationship between initial HbA1c and the stverity of pulmonary tuberculosis on chest X-ray. During treatmenu of pulmonary tuberculosis in excellently and well controlled diabetes, the cure rate of pulmonary tuberculosis was sigrificantly higher than the pcorly controlled diabetes and the rate of treatment failure was significantly lower than poorly controlled diabetes. (p<0.05). CONCLUISON: Poor control of blood glucose is related with increased rate of treatment failure in pulmonary tuberculosis with diabetes mellitus. Further investigation will be needed to study the mechanisms of treatment failure in poorly controlled diabetics with pulmonaiy tuberculosis.
Blood Glucose
;
Diabetes Mellitus
;
Diagnosis
;
Humans
;
Incidence
;
Lung
;
Male
;
Prevalence
;
Retrospective Studies
;
Sex Ratio
;
Thorax
;
Treatment Failure
;
Tuberculosis
;
Tuberculosis, Pulmonary*