The routine closed patch tests were performe0 with 41 kinds of domestic soaps, detergents, cosm etics and topical medicaments (incIuding a adhesive plaster) on the intact skin of the back of 100 adult males without any dermatoses, to evaluate their side effects on the skin. 1, None of the materials showed no positive reaction, 2, The over all positive reactions were observed in 21.l% of my subjects, including a 1+reacti ons in,l6,4% and a 2+or 3, In 4.7% 3, In 12 kinds of soaps, Positive reaction wer observed in 19-33% positive of my subjects (average Z7.8%) 4, In 4 kinds of detergents, positive reations were observed in 6-19% of my subjects (average 9,7%), in which the highest reaction rate revealed was IVonderful of Dongsan fats and oils co.. 5. The positive reactiors in 3 kinds of toothpastes were observed in 37-61% of my subjects (average 50.7%). 6. The positive reactions to the adhesive plaster were observed in 25% of my subjects. Arnong 17 kinds of topial medicaments, positive reaction rates above 10 shown were Aroos oirtment of Sarn-A phaxmaceutical co. (49%), PM spirit of Kyungnam pharmaceutical co. (16%), Periio ointment of Namgang pharmaceutical co. (13%), Badional-Gel of Hanil pharm-aceutcal co. (10%) and Antiphlamine of Yuhan corporation (10%). 8. In 4 kinds of cosmetic creams, all showed higher positive reaction rates, i.e, "Masan Joongang cream of Yeinvonlang No I, 41%;No.2, 35%;N0.3, 32% and E.mong cream" of Daido phanna-ceutical co,44%.
Adhesives ; Adult ; Detergents ; Fats ; Gyeongsangnam-do ; Humans ; Male ; Oils ; Patch Tests ; Skin ; Skin Diseases ; Soaps* ; Toothpastes

Fifty-one cases of various warts were treated with 1-cbloro-2,4-dmitrobenzene (DNCB), and divided these warts into two groups by the method of treatment. The first group was treated by challenge on normal skin a,fter sensitization and the second group was treated by challenge on wart lesion after sensitization. The number of first group was 27 consisted of 13 of verruca vulgaris, 12 of verruca plana and 2 of condyloma acuminatum. The number of second group was 24 consisted of 10 of verruca vulgaris, 11 of verruca plana and R of verruca plantaris. The results are summarized as follows; 1. Thirty-one of all 51 cases (60. 7%) were cured. 2. Fifteen of 27 cases (55.5%) were cured in first group. 3. Sixteen of 24 cases (66. 6%) were cured in second group. 4. All 3 cases of verruca planaris were cured in second group. 5. Eight cases were cured only by sensitization and consisted of 6 of verruca plana and of verruca vulgaris. 6. There was no significant difference in cure rates of warts between the group within 2 years of duration and the group over 2 years of duration. 7. There were no severe adverse reactions.
Dinitrochlorobenzene* ; Immunotherapy* ; Skin ; Warts*

A typical case of lichen amyloidosis is reported. This case is considered to be the first one in Korea. Intralesional injection of prednisolone proved to be effective in this case. The etiologic and therapeutic aspects of this disease are discussed.
Amyloidosis* ; Injections, Intralesional ; Korea ; Lichens* ; Prednisolone

No abstract available.
Mast Cells* ; Skin Diseases*

This study was undertaken to investigate the response of non-immunologic contact urticaria(NICU) test before and after ingestion of cyclo-oxygenase inhibitors such as naproxene, ibuprofen and mefenamic acid. Forty patients who showed positive reaction to 5% benzoic acid (BA) in petrolatum by 20 minutes closed patch test were chosen and divided into 3 groups. Group I was consisted of 13 patients who were taken naproxene 250mg bid, group II, 14 patients, taken ibuprofen 600mg bid, and group III, 13 patients, taken mefenamic acid 500mg bid. All the patients were tested with 5%, 2.5%, 1%, 0.5% and 0.1% BA in petrolatum using Finn chamber on Scanpor tape on the right arm before medication and next day on the left arm after medication of each day. Mefenamic acid did not show any significant differences before and after ingestion of drug. Naproxene reduced reaction about half of patients. Ibuprofen reduced reaction in almost all patients and blocked reaction completely in 9 of 13 patients. This results suggested that there was no correlation between blocking effect to BA induced contact urticaria and so called anti-inflammatory potencies of naproxene and ibuprofen, and that NICU by BA is partly mediated by prostaglandins(PG) or mediated by other mediators, which were potentiated by PG, except histamin.
Arm ; Benzoic Acid ; Cyclooxygenase Inhibitors ; Eating ; Humans ; Ibuprofen ; Mefenamic Acid ; Naproxen ; Patch Tests ; Petrolatum ; Urticaria*

Mental retardation (MR) is classically deficits in adaptive behavior and manifest during the developmental period. The causes of mental retardation were not understood in many cases. This study was undertaken to identify the etiologies of mentally retarded children enrolled in a special educational institution under the hypothesis that clarifying causes of MR can not only provide basic epidemiological data on MR in Korea, but also imply possibly preventable measures to avoid MR in some cases. In this study, complete medical history was taken in addition to a thorough individual physical examination with collection of urine specimens for metabolic screening tests including ferric chloride, DNPH, nitrosonaphthol, nitroprusside, CTAB, and reducing substance tests in 259 mentally retarded children aged between 3 through 18 year old. The cytogenetic, molecular genetic, and endocrine studies wire performed in 14 children with high clinical suspicion of chromosomal abnormalities and congenital hypothyroidism. Dysmorphism syndromes were delineated using computer software software program. Definite or presumptive etiological diagnosis has been made in 122 (47%) mentally retarded children, Among three major identifiable causes, perinatal brain damage resulted from difficulties in labor, prematurity, kernicterus, and neonatal sepsis, was most commonly found in 57 children (22%), followed by chromosomal abnormalities including Down's syndrome and fragile-X syndrome in 35 children (13.5%), and dysmorphism syndrome in 10 children (3.9%) in order. Other identifiable causes for mentally retarded children were listed as autism (2.3%), endocrine & hereditary metabolic disease (1.9%), central nervous system malformations, neurophakomatoses (1.9%), and postnatal accidents, poisoning, infection (1.5%). In conclusion, aforementioned data suggested that one fourth of MR can be avoided or treated by making efforts to improve peri, postnatal care and early detection. Routine urinary metabolic screening tests for inborn errors cannot be justified though CTAB test showed high specificity for the diagnosis of mucopolysaccharidosis. Some mentally retarded children's families need genetic counselling since Mendelian inherited disorders are culpable for causing MR in some children.
Adaptation, Psychological ; Adolescent ; Autistic Disorder ; Brain ; Central Nervous System ; Child* ; Chromosome Aberrations ; Classification* ; Congenital Hypothyroidism ; Cytogenetics ; Diagnosis ; Down Syndrome ; Humans ; Intellectual Disability ; Kernicterus ; Korea ; Mass Screening ; Mentally Disabled Persons* ; Metabolic Diseases ; Molecular Biology ; Mucopolysaccharidoses ; Nitroprusside ; Physical Examination ; Poisoning ; Postnatal Care ; Sensitivity and Specificity ; Sepsis

Two cases of pseudoxanthoma elasticum associated with angioid streaks in both eyes were presented and the literatures were reviewed. The affected sisters were 15 and 18 years female among the five siblings. They had pin head sized yellowish maculopapular eruptions on the sides of the neck and axillae, and also visual distubance of the both eyes. They seemed to be autosomal recessive inberitance in their family background. There were no other complications.
Angioid Streaks ; Axilla ; Female ; Head ; Humans ; Neck ; Pseudoxanthoma Elasticum* ; Siblings

Five cases of erythema dyschromicum perstans which seem to be the first cases in Korea are described. They are healthy subjects with moderately pigmented skin. Numerous gray-blue macules are seen on the covered part of the body in two patients, but dark brownish macules in other three patients. Histologic findings reveal the characteristic features of hydropic degeneration of the basal cell layer of the epidermis, perivascular infiltrates of lymphocytes and histiocytes and melanin-laden macrophages in the corium in four patients, however, merely pigmentary incontinence into the corium in one patient. We think that there are some problems in cases which show the chracteristic features of erythema dyschromicum perstans histologically but do not have peculiar clinical features, e.g. color of the lesion, especially in Oriental. In this respect, though there may be down for much discussion in three cases which have not typical color of the lesion, we report these cases with typical two cases under the name of erythema dyschromium perstans in order to accumulate more knowledge of these problems
Dermis ; Epidermis ; Erythema* ; Histiocytes ; Humans ; Korea ; Lymphocytes ; Macrophages ; Skin

Nevus lipomatosus cutaneous superficialis is a very rare skin disease which is characterized by the ectopic presence of rnature adipose tissue in the dermis. There are two clinical variants. The first type is the multiple lesions of zonal distribution usually on the buttocks or the lower back area. Sometimes coalescence of the papules tend to form cerebriform plaques. The second type is the solitary papule or nodule with less restricted tendency in its distribution. We describe a 24-year-old female patient who had a soft yellowish, well defined, fetal head-sized cerebriform tumor with comedo-like plugs on the right buttock and the perineal area. The skin lesions began about 10 years ago and gradually increased in size. Routine laboratory findings were within the normal limit. Histopathological findings are hyperkeratosis, acanthosis, deep crypt-like indenation in the epidermis, and ectopic collection of mature adipose tissue in the derrnis. Diagnosis was confirrned by clinical and histopathological findings. Literature was briefly reviewed for discussion.
Adipose Tissue ; Buttocks ; Dermis ; Diagnosis ; Epidermis ; Female ; Fluconazole ; Humans ; Nevus* ; Skin ; Skin Diseases ; Young Adult

Nevus flammeus is benign but cosmetically devastating congenital vascular malformation whose past treatments have been marred by unacceptable complication or by unacceptable ineffectiveness. The argon laser is a therapeutic device which has been newly applied to this condition. Blue-green argon light is absorbed by the intraluminal red hemoglobin molecule, leading to the destruction of blood vessels. This study was undertaken to evaluate the therapeutic effect, to look for complications caused by the argon laser on nevus flammeus and to investigate the prognostic values of the color, the degree of blanching and the histological pattern of lesion after laser treatment. All patients were treated with Coherent Radiation Model No. 1,000 Laser with a spot size of 1mm diameter. The power range was 1.8W (irradiance of 229W/cm2), the pulse duration was 0.4 second and the repetition rate was 120 impulses per minute. The result was evaluated according to the criteria of Gilchrest(Table 1). Among the 109 patients who have been treated between November, 1981 and July, 1982 at the Department of Dermatology, Seoul National University Hospital, data from the 49 patients who could be followed up was evaluated and analyzed. (countinued..)
Argon* ; Blood Vessels ; Dermatology ; Humans ; Laser Therapy* ; Nevus* ; Port-Wine Stain* ; Seoul ; Vascular Malformations