1.Production of human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus transformation.
Seung Min YOO ; Jeong Je CHO ; Soon Tae HO ; Youn Mun HA
Korean Journal of Immunology 1993;15(2):139-146
No abstract available.
Antibodies, Monoclonal*
;
Herpesvirus 4, Human*
;
Humans*
;
Tetanus Toxoid*
;
Tetanus*
2.S Antigen Specific Rat Helper T Cell Line Induced Experimental Autoimmune Uveoretinitis.
Youn Mun HA ; Soon Tae HO ; Jeong Je CHO ; Seung Min YOO
Korean Journal of Immunology 1997;19(2):181-188
No abstract available.
Adaptive Immunity
;
Animals
;
Cell Line*
;
Rats*
3.Production of monoclonal antibody to Epstein-Barr virus antigen.
Jeong Je CHO ; Soon Tae HO ; Seung Min YOO ; Youn Mun HA
Korean Journal of Immunology 1992;14(1):117-131
No abstract available.
Herpesvirus 4, Human*
4.A Case of Clear Cell Sarcoma of the Anterior Chest.
Sang Hak LEE ; Jin Ho CHO ; Seung Min HONG ; Byung Mun CHOI ; Yoo Shin LEE
Korean Journal of Dermatology 1989;27(4):477-480
Clear cell sarcoma of tendon and aponeurosis is a rare malignant tumor. It occurs chiefly in young adults, predominates in women and is most common in the regions of the foot and ankle. We report a case of clear cell sarcoma of tendon and aponeurosis in s 22-year-old man. he pstient had had a asymptomatic, normal skin colored, relativerly hard, dome shsped nodule on the anterior chest for 6 months. Histopsthologic findings revealed uniform pattern composed of compact nests of round or fusiform cells which had clear cytoplasm and were surrounded by delicate framework of fibrocollagenous tissue, and the individual tumor cell had a fairly regular appearance of possessing round to avoid vesicular nucleus with prominent basophilic nucleolus. One year after surgical excision and post operative radiotherapy, there was no recurrence.
Ankle
;
Basophils
;
Cytoplasm
;
Female
;
Foot
;
Humans
;
Radiotherapy
;
Recurrence
;
Sarcoma, Clear Cell*
;
Skin
;
Tendons
;
Thorax*
;
Young Adult
5.Usefulness of Spiral CT for T Staging of Gastric Carcinoma.
Kyung Sub SHINN ; Hong Jun CHUNG ; Jae Mun LEE ; Myung Ho RHO ; Su Yeon YOO ; Chun Yeul KIM
Journal of the Korean Radiological Society 1995;33(4):575-580
PURPOSE: To evaluate the usefulness of spiral CT in predicting the depth of tumor invasion in patients with gastric cancer by comparing with histopathological finding. MATERIALS AND METHODS: We studied spiral CT scans of forty-eight patients, in whom gastric cancer was proven by gastrofibroscopic biopsy and surgery. After distending the stomach with 400ml tap water or effervescent granules, 100ml of contrast media was given intravenously at a rate of 3ml/sec. CT scanning was started at 45 sec after administration of the contrast material. Gastric tumors were subdivided into five types according to enhancing pattern from the inner layer of gastric wall to the outer layer. These pattern were correlated with histopathologic results. RESULT: The tumor masses were detected on CT scan in 10(77%) of 13 patients with early gastric cancer, while, the tumor masses were seen on CT scan in all patients with advanced gastric cancer. Of 9 patients with type 1 or type 2 enhancing pattern, early gastric cancer(T1) were proven in 7 patients(78%), serosal invasion (T3) in 2 patients(22%). In contrast, among 29 patients with type 4 and type 5, 22 patients(76%) were proven as serosal invasion(T3). Of 7 patients with type 3, 3 patients(43%) were proven as serosal invasion(T3), three(43%) as subserosal invasion(T2), one as early gastric cancer(T1). CONCLUSION: Analysis of morphological enhancing pattern on spiral CT is useful in predicting the depth of tumor invasion in patients with gastric cancer.
Biopsy
;
Contrast Media
;
Humans
;
Stomach
;
Stomach Neoplasms
;
Tomography, Spiral Computed*
;
Tomography, X-Ray Computed
;
Water
6.The Value of Increased Nuchal Translucency(NT) for the Prediction of Abnormal Pregnancy Outcome.
Eun Sung KIM ; Ho Won HAN ; Hyun Mee RYU ; Jae Hyuk YANG ; Mun Young KIM ; Shi Jun YOO ; Young Ho LEE ; Jung Ryol HAN ; Kyung Sang LEE
Korean Journal of Perinatology 1998;9(4):363-374
PURPOSE: To evaluate the NT in the first trimester associated with fetal chromosomal abnormality, fetal structural abnormality and adverse pregnancy outcome. METHODS: From Mar. 1993 to Dec. 1997, 133 cases of increased NT were reviewed retrospectively. All these fetues were taken a karyotyping and/or a high resolution ultrasonography for associated anomaly. The NT was measured by transvaginal ultrasonography(TVS) and transabdominal ultrasonography(TAS) if difficulty was encountered with TVS in the period of the 10th-14th week of gestation. The increased NT is approved when it is over 3mm. RESULTS: Of these 133 cases, 102 cases(76.7%) revealed normal outcomes and 31 cases(23.3%) revealed abnormal outcomes such as chromosomal abnormality, structural abnormality and adverse pregnancy outcome, The mean value of NT was 3.44+/-0.68mm in the normal group and 4.93+/-2.70mm in the abnormal group, respectively. The chromosomal abnormalities were found in 16 of the 31 cases: nine Down SD, two Patau syndrome, one Tuner synrome, one triploidy, one 46, XX,i(18q), one 47,iso(Xp)/46,XX one confined placental mosaicism. In 12 cases of the 31 cases, the structural anomalies were detected. Of these 12 cases, 3 cases were eventually developed to cytsic hygroma, 3 cases were cardiac anomaly, 3 cases were renal anomaly, 1 case was congenital diaphragmatic hernia, 1 case was skeletal dysplasia and 1 case was suspected syndrome. The adverse pregnancy outcome such as intrauterine growth restriction, intrauterine fetal death and preterm labor was revealed in 3 cases. In the cases of NT over 7mm, the result was 100% abnormal outcome. CONCLUSION: Increased NT in the first trimester could be a highly efficient the predictor for detection of chromosomal abnormality, structural anomaly and adverse pregnancy outcome.
Chromosome Aberrations
;
Female
;
Fetal Death
;
Hernia, Diaphragmatic
;
Humans
;
Karyotyping
;
Lymphangioma, Cystic
;
Mosaicism
;
Nuchal Translucency Measurement
;
Obstetric Labor, Premature
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy Trimester, First
;
Pregnancy*
;
Retrospective Studies
;
Triploidy
;
Ultrasonography
7.Ascertainment of Clinical Usefulness of Neurosurgery Simulator(R) in Stereotactic & Functional Neurosurgery.
Mun Ho CHOI ; Ryoong HUH ; Young Sun CHUNG ; Byung Soo YOO
Journal of Korean Neurosurgical Society 2003;34(4):303-308
OBJECTIVE: An usefulness and an accuracy of Neurosurgery Simulator(R)(NSS(R)) is evaluated for the clinical applications. The NSS(R) is a surgical planning tool for stereotactic and functional neurosurgery, recently developed in Korea. METHODS: Thirty-four surgical cases, performed with the NSS(R) from October 1999 to April 2002, were analyzed. The accuracy was examined by comparing the actual lesion with the planned target. The usefulness was discussed with time consuming factor and convenience for surgical steps. Results of surgical outcome were also reviewed. RESULTS: The precise coordinates of surgical target is directly acquired by designating an anatomical lesion on the magnetic resonance image with NSS(R) due to auto recognition algorithm of the fiducials on the MRI image. The correctness is confirmed again by examining the anatomical lesion with superimposing the Schaltenbrand-Wahren atlas on the image directly. Among eleven cases of the thalamotomy for tremors, five cases resulted in complete resolution, the remaining five patients showed significant reduction of tremors. Improvement of ADL and UPDRS was recorded in all 6 Parkinson's disease patients who had undergone pallidotomy. Seventy five percent of patient in pain and psychosurgery resulted in improvements. The NSS(R) achieved 100% accuracy in calculating stereotactic biopsy coordinates. There was no deviation in guiding surgical trajectory. There was no significant surgical complication. CONCLUSION: Stereotactic and functional neurosurgery performed with the assistance of the NSS(R) is relatively safe and accurate.
Activities of Daily Living
;
Biopsy
;
Humans
;
Korea
;
Magnetic Resonance Imaging
;
Neurosurgery*
;
Pallidotomy
;
Parkinson Disease
;
Psychosurgery
;
Tremor
8.Generation of monoclonal antibodies reactive to human interleukin 2(IL 2).
Youn Mun HA ; Jun Hyung LEE ; Seung Min YOO ; Jeong Je CHO ; Soon Tae HO ; Jae Kyung PARK ; Sang Yun NAM
Journal of the Korean Society for Microbiology 1993;28(4):313-319
No abstract available.
Antibodies, Monoclonal*
;
Humans*
;
Interleukins*