By making investigation on the animals with venom protein and peptied.In China sea we find that Coelenterata of them mainly includes 14 kinds of Jellyfist,15 kinds of Sea anemone,one kind of Corals and two kinds of Hydrozoa,altogether 32 kinds;Mollusea of them mainly includes 34 kinds of Conus,two kinds of Aplysia and 3 kinds of Cephalopoda,altogether 39 kinds;Nemartina of them has one kind;Echinodermata of them mainly includes two kinds of starfish and 8 kinds of Sea urchins,altogether 10 kinds;fishes of them mainly include one kind of Venomous fishes,two kinds of Ichthyocrinotoxic fishes and 74 kinds of Venomous fishes,altogether 77 kinds;Sea snake is 15 kinds.These animals with venom protein and peptide mainly are distributed in South sea of China.

Comparative effectiveness research (CER) has gained more and more popularity, which brought great response in the USA and other developed Western countries. There is no doubt that CER is a new idea and a milestone in health care research. CER is also known as "patient-centered outcomes research", which means patient is the core element in the whole system of CER. Chinese medicine could make new achievements and further development by introducing CER into clinical research. This article mainly introduced the background, features and contents of CER and summarized how to conduct CER in Chinese medicine by referring to some published literature in order to enlighten Chinese medicine researchers.

This study was intended to assess the therapeutic effect and toxicity of Compound vincristine liposome on breast cancer in nude mice. The mammary cancer models of BALB/c nude mice were set up using MCF-7 cells, and were divided into seven groups: MTO-VCR-LP, MTO-VCR-Soln, VCR-LP, VCR-Soln, MTO-LP, MTO-Soln and 0.9% NaCl. After the first treatment in the same day of transplantation, different treatments were given respectively. According to the design, the BLAB/c nude mice were given the therapy, the weight of nude mice and tumor volume were measured, and the tumor growth inhibitory rate was calculated. Bone marrow smears and extravasation injury were observed. The tumor growth inhibitory rates were higher in MTO-VCR-LP and MTO-VCR-Soln groups than in other groups. MTO-VCR-Soln, VCR-Soln and MTO-Soln led to severe local extravasation injury. MTO-VCR-Soln cause serious bone marrow inhibition of nude mice. The average weight of nude mice in the three liposome groups was higher than that in the three solution groups. So the use of liposome as the carriers of the two anticancer drugs could improve the cure rate of cancer and decrease the side-effects. This work, which not only expanded the research field of liposome but also brought in new ideas and new methods to treat cancer. Furthermore, the findings in this research may have the potential for use in clinical practice.
Animals ; Drug Carriers ; Drug Synergism ; Female ; Liposomes ; administration & dosage ; Mammary Neoplasms, Experimental ; drug therapy ; pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitoxantrone ; administration & dosage ; adverse effects ; Neoplasm Transplantation ; Random Allocation ; Vincristine ; administration & dosage ; adverse effects

Objective To analyze the correlation between the prevalence of chronic non-communicable diseases (NCDs) and fall incidence among the elderly in urban and rural areas in Chongqing, and to provide evidence for targeted intervention. Methods In 2019, a questionnaire survey was conducted among the elderly aged 65 and over in four districts and counties using multistage stratified cluster random sampling. The difference of NCDs prevalence and fall incidence was compared by Chi-square test. The correlation between NCDs and fall incidence was analyzed by multivariate logistic regression. Results A total of 806 and 801 elderly people aged 65 and above in urban and rural areas，respectively, were investigated The fall incidence among the elderly in rural areas (12.98%) was higher than that in urban areas (7.94%) (χ2=10.916, P=0.001). The multivariable logistic regression analysis showed that the prevalence of heart disease (OR=2.988, 95%CI:1.544-5.785), osteoporosis (OR=2.696, 95%CI:1.527-4.760) and vestibular dysfunction or deafness (OR=3.180, 95%CI:1.142-8.861) was associated with fall incidence among urban elderly people. Factors including need for care (OR=2.315，95%CI：1.130-4.744), diabetes (OR=3.067，95%CI:1.634-5.756), osteoporosis (OR=1.972, 95%CI:1.210-3.214), and arthritis (OR=2.975, 95%CI:1.901-4.657) were associated with fall incidence among rural elderly people. Conclusion The fall incidence among the elderly in rural areas is higher than that in urban areas in Chongqing. The prevalence of NCD is high among the elderly. Timely treatment of NCDs should be provided to reduce fall incidence among the elderly.

Although different types of drugs are available for postmenopausal osteoporosis, the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis agents. Here, we defined that norlichexanthone (NOR), a natural product, is a ligand of estrogen receptor-alpha (ER