Objective To explore the application of nursing intervention model based on motivational stimulation in glaucoma patients.Methods A total of 120 glaucoma patients selected from January 2014 to December 201 4 in our hospital were randomly divided into experimental group and control group on average. Patients in experimental group received nursing intervention based on motivational stimulation,while patients in control group received routine nursing care.Treatment compliance after nursing,average intraocular pressure, cup-to-disc ratio of optic nerve,mean defect and quality of life were compared between two groups.Results The ratio of treatment compliance in experimental group was significantly higher than the ratio in control group (P <0.05).Average intraocular pressure,cup-to-disc ratio and mean defect in experimental group were significantly lower than those in control group (P <0.05).Quality of life score in experimental group (75.95 ±7.52)was higher than (65.77 ±8.52)in control group (P <0.05).Conclusions Nursing intervention model based on motivational stimulation could increase the ratio of treatment compliance so as to achieve better disease control and improve life quality in glaucoma patients.