The essence of precision medicine (PM) is to find the disease pathogenesis,mechanism and treatment targets through large sample population and specific disease type of biomarker exploring,quantitative analysis,verifying and application.Metabolomics,as one of the technologies testing the metabolites in vivo,can be used to predict the level of metabolites in vivo and to diagnose the physiological state of the body in time for guiding the corresponding intervention.This article summarized the application of metabonomics in the precise diagnosis,pathogenesis and treatment of cardiovascular disease.