1.On cultivation of comprehensive Chinese qualities of medical students
Chinese Journal of Medical Education Research 2006;0(11):-
Chinese education is instrumental,fundamental,aesthetic and humanistic.It is the strongest support to culture qualified medical personnel.College Chinese can improve the humane quality of medical students.This process can be developed in many different aspects,such as morality education,the improvement of culture quality and intelligence,and the cast of their souls,etc.
2.On Dimensions of the Cultivation of Comprehensive Chinese Qualities of Medical Students
Chinese Medical Ethics 1994;0(05):-
Chinese education,as an education course to strengthen the humane quality of our native language,is instrumental,fundamental,aesthetic and humanistic.It is the strongest support to culture qualified medical personnel.College Chinese can achieve the span of humane quality of medical students.This process can be developed in many different dimensions,such as morality education for college students,the improvement of culture quality and intelligence,the cast of their souls,cultivation of modern thinking mode and thinking level,the improvement of their comprehensive capabilities and that of their social abilities as well as the abilities to master and use the language.
3.Effects of kinesio taping on lower limb function after stroke: a meta-analysis
Chinese Journal of Physical Medicine and Rehabilitation 2021;43(2):170-176
Objective:To review the effect of kinesio taping on the lower limb function of stroke survivors.Methods:PubMed, Web of Science, Embase, the Cochrane Library, China′s National Knowledge Internet (CNKI), China Biology Medicine (CBM), Weipu Chinese Science and Technology Periodical Database and the WanFang Database were searched for reports of randomized and controlled trials (RCTs) testing the effect of kinesio taping on the lower limb function of stroke survivors published between January 1st, 2000 and October 1st, 2019. Two reviewers independently screened the reports, extracted data and assessed the risk of bias in the studies included. Version 5.3 of the RevMan software was used to analyze the extracted data.Results:A total of 13 RCTs involving 932 patients were included. Meta-analysis showed that the experimental group was significantly superior to the control group in terms of the improvement in walking speed and function, balance, fall risk, quadriceps strength, leg triceps strength, and general lower limb motor functioning. Their ability in the activities of daily living was also better on average as was their general life quality.Conclusions:Kinesio taping can improve stroke survivors′ balance, motor ability, muscle strength and life quality.
4.Correlation between platelet-associated antibody and platelet infusion effects
Yongxin WANG ; Yingxiu ZHAO ; Yanxin HUANG
Chinese Journal of Primary Medicine and Pharmacy 2011;18(17):2343-2344
Objective To investigate the correlation between platelet-associated antibody and platelet infusion effects.Methods SEPSA was used to detect the platelet-associated antibody of 79 patients with multiple transfusions of platelet,the platelet count before and after platelet infusion was monitored and the corrected count increment (CCI) in lh and 24h were calculated,for those judged to be ineffective platelet infusion,the platelet cross-matching was first done and then received matching infusion again and the infusion effects were analysed. Results 47 cases were detected with platelet antibody positive in 79 patients,accounting for 59.5% ,the CCI of lh and 24h after infusion in platelet antibody positive group were significantly lower than the negative group, the difference was statistically significant( t = 2. 462、2. 583, all P < 0. 05 ) ;40 cases in positive group had the invalid with the invalid rate of 85.1%which was significantly higher than the negative group, the difference was statistically significant ( x2 = 34. 46, P <0. 05 ) ;the CCI of 1h and 24h after infusion in matching success group were significantly higher than the unsuccessful group, the difference was statistically significant( t = 2. 152、2. 230, all P < 0. 05) ;27 cases in matching success group had the effective infusion with the effective rate of 87. 1% ,which was significantly higher than the unsuccessful group, the difference was statistically significant ( x2 = 4. 34, P < 0. 05). Conclusion The production of anti-platelet antibody was a major immune factor which lead to platelet transfusion refractoriness ,the blood platelet cooperative infusion could be a good solution for the platelet transfusion refractoriness.
5.Effects of siRNA Silenced ERK1/2 Gene Collaborated withJiakangning Capsules on FRTL-5 Proliferation
Lan LIN ; Qiuhong WANG ; Yongxin YI
Chinese Journal of Information on Traditional Chinese Medicine 2016;23(6):43-46
ObjectiveTo observe and explore the effects ofJiakangning Capsules on the expression of ERK1/2 gene and proliferation of FRTL-5 by studying the effects ofJiakangning Capsules collaborated with siRNA on interfering ERK1/2 gene in FRTL-5.Methods FRTL-5 cells in good conditions were divided into control group, negative control group,Jiakangning Capsules collaborated with siRNA group, siRNA interference group, and Jiakangning Capsules group. RT-PCR was performed to detect the expression of ERK1/2 gene in mRNA levels in FRTL-5; Western blotting was performed to detect the expressions of ERK1/2 and p-ERK1/2; CCK8 method was used to detect cell proliferation.Results RT-PCR results showed that the ERK1/2 mRNA expression of the control group and negative control group were of no significant difference (P>0.05); compared with the control group, siRNA interference group andJiakangning Capsules group could inhibit ERK1/2 gene mRNA expression in FRTL-5 (P<0.01). Compared with the control group and negative control group, the ERK1/2 mRNA expression of Jiakangning Capsules collaborated with siRNA group decreased obviously (P<0.01). Compared with the control group and negative control group, the expression of p-ERK1/2, ERK1/2 ofJiakangning Capsules group, Jiakangning Capsules collaborated with siRNA group, and siRNA interference group decreased obviously (P<0.01). At the time of 24 h and 48 h after transfection, according to the results of CCK8, compared with the control group and negative control group, the cell proliferation ofJiakangning Capsules group, Jiakangning Capsules collaborated with siRNA group, and siRNA interference group was inhibited (P<0.01).Conclusion Jiakangning Capsules have blocking effect on the phosphorylation of ERK1/2. After ERK1/2 gene was silenced, the thyroid cell proliferation was inhibited. Jiakangning Capsules can collaborate with ERK1/2-siRNA to inhibit FRTL-5 cell proliferation.
6.Classic intrafascial supracervical hysterectomy by including the clipping of the uterine artery: Report of 60 cases
Yongxin LU ; Chong WANG ; Xinfeng SHI
Chinese Journal of Minimally Invasive Surgery 2001;0(04):-
Objective To investigate the clinical value of classic intrafascial supracervical hysterectomy(CISH) by including the clipping of the uterine artery.Methods A total of 60 cases of benign uterine diseases were included in the study.After the uterine artery had been dissected and clipped on both sides under laparoscope,classic intrafascial supracervical hysterectomy was performed.Results All the operations were performed successfully under laparoscope.No conversions to open surgery were needed.Operating complications happened in no case.The operating time was 72~186 min(91.4?26.3 min),the amount of blood loss was 50~150 ml(76.5?20.6 ml),the time to postoperative gastrointestinal function recovery was 18~30 h(22.7?5.8 h),and the volume of pelvic drainage within 24 hours,50~160 ml(80.5?31.8) ml.Postoperative body temperature was elevated to 38.5 ℃ in 2 cases,the postoperative pyrexia rate being 3.3%.The length of postoperative hospital stay was 4~7 d.Follow-up for 6~18 months(10.6?4.2 months) in the 60 cases showed 3 cases of small amount of vaginal bleeding at 1~3 months,which were cured with the use of antibiotics and hemostatics for 5~7 d.Conclusions Classic intrafascial supracervical hysterectomy by including the clipping of the uterine artery is a safe and effective improvement to CISH technique.
8.Total Laparoscopic Hysterectomy with Separating Uterine Arteries: A Report of 68 Cases
Yongxin LU ; Chong WANG ; Xinfeng SHI
Chinese Journal of Minimally Invasive Surgery 2005;0(10):-
Objective To investigate the clinical efficacy of total laparoscopic hysterectomy(TLH) with separating and blocking uterine arteries.Methods From January 2004 to June 2006,68 cases of uterine benign diseases underwent TLH by blocking uterine arteries after separating and clipping uterine arteries with Titanic clip.Results All operations were performed successfully without conversion to open surgery and complications.1 patient,who had twice gastrohysterectomy histories,underwent bipolar coagulating uterine arteries as to the failure of separating bilateral uterine arteries.Pelvic adhesion release was performed in 18 cases,unilateral or bilateral adnexectomy in 14 cases,oophorocystectomy in 8 cases,appendectomy in 1 case,and cholecystectomy in 1 case simultaneously.The operation time was 90-185 min,(112.6?27.5)min.The time of separating uterine artery in one side was 3-15 min,(5.2?3.4)min.The intraoperative blood loss was 50-150 ml,(86.5?39.6)ml.The time to first bowel movement was 18-48 h,(27.3?4.8)h.The rate of postoperative pyrexia was 4.4%(3/68),and the hospital stay was 4-7 d,(5.1?1.8) d.A follow-up period of 2-6 months,(3.5?1.6) months,showed 3 cases of vaginal dropping hemorrhage 1-2 months after operation,which was cured with the use of antibiotics and hemostatics for 5-7 d.Conclusions TLH with separating and blocking uterine arteries is a safe,effective and feasible procedure with less complication,so it is worthy of being recommended.
9.The inductive treatment of erlotinib before operation in patients with NSCLC in stage ⅢA
Gaofeng LI ; Qian WANG ; Yongxin JIANG ; Weiwei WANG ; Nan CHEN
Cancer Research and Clinic 2008;20(8):532-533
Objective To explore the effect of erlotinib in patients with non-small-cell lung cancer (NSCLC)in stage ⅢA before operation and the relation with the rate of resection,good operability and postoperative complications.Methods 31 patients with NSCLC in stage ⅢA in group A were treated with erlotinib before operation;34 patients with NSCLC in stage ⅢA in group B only were treated with operation.Results The condition of 64.5%patients were improved.The operability in group A was more than that in group B(P=0.008),the good operability in group A was more than that in group B(P=0.011),the postoperative complications do not have statistical significance (P=0.07).Conclusion The erlotinib can increase the rate of resection in patients with NSCLC in stage ⅢA,and increase good operability in patients with NSCLC in stage ⅢA,but not increase the postoperative complications.
10.Radiosensitization of artemisinin and its derivatives in tumors
Yanjun WANG ; Yongxin JIANG ; Shan LIU ; Hong WANG ; Lyu GE
Journal of International Oncology 2016;43(8):612-614
Artemisinin and its derivative is a kind of efficient,quick and low toxicity of anti-malarial drug.In recent years,we find that artemisinin drugs can not only against malaria,but also have pharmacological effects of immunosuppression,antiviral and anticancer.A number of studies have confirmed that artemisinin and its derivatives have the radiosensitization effects in nasopharyngeal carcinoma,cervical cancer,lung cancer and glioma,and their mechanisms are related to decreasing Weel protein expression,increasing Cyclin B1 protein expression,blocking G2-M phase and cell apoptosis.