Liuwei Dihuang decoction（LW），a classical traditional Chinese medicinal prescription with the effect of “nourishing Kidney-Yin”，consists of six herbs including Rehmannia glutinosa (Shudi),Cornus officinalis(Shauzhuyu)，Dioscorea opposita(Shanyao)，Alisma orientale(Zexie)，Porie cocos（Fuling）and Paeonia suffruticosa（Mudanpi）．It has long been used clinically in the treatments of many kinds of diseases with the sign of “Kidney-Yin deficiency”，such as cancer，diabetes，autoimmue diseases，menopausal syndrome in traditional Chinese medical treatments．The effectiveness of it has been well documented during the long-term clinical practices．In our study，the effects and the possible active mechanisms of LW on learning and memory ，neuroendocrine and immune functions were studies from the angle of neuroendocrine immunomodulation（NIM）network ．In chemical fractionation and purification of the immunoactive fractions or components contained in LW，the method of a close collaboration between pharmacological and chemical studies was employed．The chemical fractionation was begun from the decoction and guided by pharmacological activity evaluation．The results showed that oral administration of LW significantly improved learning and memory abilities in several kinds of model animals such as senescence accelerated mice (SAM)，chronic hanging stress-loaded mice and corticosterone-treated mice and the mechanism studies suggested that the effects were achieved through several ways．LW significantly decreased the plasma level of corticosterone in SAM-prone/8 (SAMP8) ，a substrain of SAM．SAMP8 showed a marked elevation of plasma level of corticosterone with advancing age in comparison with SAMR1 ，a substrain of senescence resistant of SAM．LW also significantly improved the secretion of testosterone by primary cultured testis cells from SAMP8．The immunopharmacological studies showed that oral administration of LW not only improved the immune functions in several immunodeficient model animals such as cyclophospharmide-treated mice and SAMP8，but also modulated or corrected the imbalance of immune functions manifested in autoimmune model animals includig adjuvant arthritis rats and campylobacter jejuni primed mice．Under the guidance of activity evaluation，several immunoactive fractions and pure compounds were obtained from the decoction．The effects of some fractions and compounds were studied and the results showed that they possessed potential immunopharmacological effects．The preliminary study suggested that LW possessed wide pharmacological effects and the basic effect of LW，we postulate，is modulation the balance of NIM network disturbed in many pathological conditions．It is also suggested that our method employed in the study of LW is an effective and practicable way in modern studies of tradltional Chinese medicinal prescriptions．

0.05).The serum PICP in the non-intervention group was significantly lower after 4 weeks' treatment as compared with before treatment or control group,and the urine excretory rate of DPD significantly increased after treatment as compared with before treatment or control group(all P

Objective To investigate the feasibility and safety of radical resection of colorectal carcinoma with laparoscopy.Methods Clinical data of 48 patients who underwent laparoscopic colorectal cancer resection and 131 patients who underwent traditional radical resectin were retrospectively analyzed.Results The incision length,first flatus time,intestinal intervention times,the first meal time,urinary catheterization time,gastric tube retaining time,drainage tube lien time,analgesia time of the laparoscopic group significantly decreased compared with those of conventional surgery ( P ＜ 0.05 ).There was no significant difference in complication occurrence,postoperative hospitalization time and overall hospitalization time between the two groups( P ＞ 0.05 ).The average operation time of laparoscopic surgery is longer than that of the traditional group (P ＜ 0.05 ).There was no significant difference between 2 groups in regarding of perioperative bleeding rate,volume of intraoperative and postoperative blood transfusions,mass maximal diameter,the distance between the distal and proximal margin and the mass in colon specimens,as well as the two variables in rectum specimens,the resected lymph node number and positive lymph node number (P ＞0.05).Conclusion Laparoscopic resection for colorectal cancer,a safe and feasible technology,is of the same short-term curative effect with traditional open surgery,but the follow-up radical curative effect is yet to be confirmed.

Polysaccharides definitely possess the effect of modulating immuno function by many ways and many targets, such as promoting the proliferation and differentiation of lymphocytes, secreting various lymphokines, modulating the balance of neuroendocrine immuno modulation network and so on. At present, the tendency of study on drugs in the world is to from synthetic drugs to natural drugs. In this review, a brief summarization is made on progress of the immuno modulating effect of polysaccharides and their mechanisms.

Objective To investigate and analyze the resources of radiotherapy in Beijing,in order to provide reference for the subject development,resources allocation and professional training of radiotherapy.Methods A questionnaire survey was conducted by on-site inspection,supplemented by telephone or e-mail investigation among the 33 hospitals with radiotherapy facilities to know the current status of distribution of radiotherapy institutions,radiotherapy facilities,human resources and number of patients treated.Results There were 52 linear accelerators,1 spiral CT machine,and 2 intraoperative radiotherapy machines in these 33 hospitals up to June 2010.Three-dimensional conformal or stereotaetic radiotherapy was carried out in 31 hospitals,intensity modulated radiation therapy(IMRT)in 19,image guided radiation therapy(IGRT)in 6,and volumetric modulated arc therapy(VMRT)in 2.The number of professional personnel(except nurses)was 495,including 214 radiation oncologists,78 radiotherapy physicists,and 203 radiotherapy technologists,and those with senior professional titles accounted for 52.3%,17.9%,and 1.5%,respectively.Conclusions Compared to the national level,the radiotherapy resources level is higher in Beijing,but the distribution of resources is imbalanced.The resource allocation should be optimized and training of the personnel should be strengthened so as to meet the growing needs of patients.

Chemical warfare agents and chemical terrorism agents have been identified as one of the major threats to human survival and national security currently. The key to dealing with these threats is the effective medical countermeasures of which specific antidotes take center stage. In the past decade,real or potential chemical threats which has sparked regional conflicts,terrorist activities or chemical accidents intentionally or unintentionally have increased the investment in antidotes research and development worldwide. Here,we introduced the research status on medical countermeasures against chemical threat by giving an overview of the United States ″Countermeasures Against Chemi?cal Threats(CounterACT)Program″,and then the recent research progress in antidotes against nerve agents,sulfur mustard and cyanide toxicities were reviewed.

The seminar on novel ideas and methods in pharmacological researches,and new drug research and development of traditional Chinese medicine(TCM),organized by the Professional Committee of Pharmacology on Traditional Chinese Medicine and Natural Medicine, Chinese Pharmacology Society,was held in Tengzhou,Shandong Province,on August 5,2016. Professor ZHANG Yong-xiang,chair of the committee,presided over the seminar. Professor LIU Jian-xun and LI Lin delivered keynote speeches. More than 30 members of the committee from all over the country attended the seminar. The participants had a broad and in-depth discussion on issues concerning phar?macological researches and new drug research and development of TCM. The ideas and proposals by some committee members were summarized,hoping to provide reference in the pharmacological researches and new drug research and development of TCM.

Objective To compare the clinical therapeutic effect of functional electrical stimulation (FES) and ankle-foot orthosis (AFO) in improving walking function in stroke patients.Methods Thirty-six stroke patients satisfying the enrolling criterion of the research were randomly divided into two groups:FES group and AFO group (n =18 in each).Both groups received the same routine rehabilitation therapy and medical treatment.Patients of FES group received FES of common peroneal nerve and tibialis anterior muscle of the affected limb,30 min per day,5 days per week,4 weeks in total,while the patients of AFO group received walking training with AFO wearing on,30 min per day,5 days per week,4 weeks in total.Walking function was assessed by 10-meter maximum walking speed,timed-up and go test (TUGT),functional ambulation category(FAC),the muscle tension of ankle flexor and Brunnstrom stage,which were carried out before treatment and four weeks after treatment.Results Before treatment,there was no significant difference between the two groups for the baseline of measurement(P ＞ 0.05).After 4 weeks of treatment,10MWT,TUGT,FAC scores and Brunnstrom stages in the two groups significantly increased (P ＜ 0.05).The 10MWT,FAC scores and Brunnstrom stage increased more significantly in FES group than those in AFO group (P ＜ 0.05).There was no significant differences with regard to TUGT and the muscle tension of ankle flexor between the two groups (P ＞ 0.05).Conclusions Both FES and AFO can accelerate the recovery of walking function in hemiplegia patients.FES can improve the walking ability in patients with stroke more significantly.

Objective To investigate the use of laparoscopy in the resection of colorectal cancers. Methods A total of 17 cases of colorectal cancer resection had been made by laparoscopy, including 3 cases of right hemicolectomy, 3 cases of sigmoid colon cancer radical resection, 7 cases of Dixon’s procedure, 2 cases of Mile’s procedure and 2 cases of Park’s procedure. The operation was accomplished totally laparoscopically in 6 cases, while the laparoscopic-assisted and hand-assisted excision were conducted in 8 cases and 3cases, respectively. Results All the cases were cured to be discharged from the hospital. There were no deaths or complications or conversions to open surgery.The operation time was 150～240 min (mean, 190 min). The intraoperative blood loss was 20～300 ml (mean, 55 ml). The average length of postoperative hospital stay was 9.6 days. Analgesic was required in 6 cases. Follow-up for 1～6 months found no recurrence. Conclusions Laparoscopic resection of colorectal cancer is safe and feasible,with a satisfactory short-term effect.

Aim To disclose the molecular mechanism of Liuwei Dihuang decoction(LW)enhances the cognitive function of central nervous system, the effects of Liuwei Dihuang decoction on the differential expression genes in the hippocampus of senescence-accelerated mouse was studied. Methods There were 8 gene expression patterns, such as SAMP8 and SAMR1, SAMP8 as negative control and SAMR1 as positive control, huperzine A-treated SAMP8 and SAMP8 as negative control, LW-treated SAMP8 and SAMP8 as negative control, were compared and assessed by use of the differential expression cDNA microarray of the hippocampus of SAMP8 and SAMR1. The response genes of LW were compared. Results LW had significant modulating effects on some of the gene expressions. Expressions of genes, such as DUSP12, NSF, STUB1, CaMKⅡ?, AMFR, UQCRFS1 and other 11 novel genes without any functional clues changed significantly. These genes involved in the protein-tyrosine phosphatase family, the AAA(ATPases associated with diverse cellular activities)gene family, the serine/threonine protein kinases family, ubiquitin ligase, mitochondrial function and so on. Conclusions These results suggested LW effects on the cognitive impairments might be multi-mechanism and these genes might be the potential gene targets for LW effects on the impairments.