BACKGROUND: The increase of leukocyte and blood glucose levels is a kind of stress reaction when acute cerebrovascular disease occurs, it often occurs at the early clinical stage of acute cerebrovascular disease.OBJECTIVE: To observe the levels of leukocyte and blood glucose at the early stage of acute cerebrovascular disease, and investigate their correlation with recent prognosis.DESIGN: A prognostic analysis based on diagnosis taken patients as observational subjects.SETTING: Qingtian County People's Hospital.PARTICIPANTS: Totally 235 inpatients with acute cerebrovascular disease aged (63.13±9.55) years were selected from Qingtian County People's Hospital between May 2000 and May 2002, including 90 cases of cerebral hemorrhage (52 males and 38 females) aged (63.13±9.55) years and 145 cases of cerebral infarction (73 males and 72 females) aged (71.22±8.00) years. The disease course ≤ 1 month. According to the number of leukocytes, the patients were divided into normal leukocyte group (n=167) and increased leukocyte group (n=68). According to the level of blood glucose, they were divided into normal blood glucose group (n=146) and hyperglycemia group (n=89). The neurologic deficit score (NDS) of 0-15 points was taken as mild, 16-30 as moderate and 31-45as severe.METHODS: All the patients received cranial CT examination immediately after admission, and fasting venous blood samples were drawn on the next morning to detect the levels of leukocyte and fasting blood glucose. The x2 test was applied.MAIN OUTCOME MEASURES: ① Comparison of age: It was obviously higher in the cerebral infarction group than in the cerebral hemorrhage group [(71.22±8.00), (63.13±9.55) years, t=6.90, P ＜ 0.001]. ② Comparison of the percentage of disease types: In the increased leukocyte group,the percentage of cerebral hemorrhage was obviously higher than that of cerebral infarction (66%, 34%, x2=31.47, P ＜ 0.005). In the hyperglycemia group, the percentage of cerebral hemorrhage was higher than that of cerebral infarction (51%, 49%, x2=9.12, P ＜ 0.005). ③ Comparison of the percentage of severe neurological impairment: It was obviously higher in the increased leukocyte group than in the normal leukocyte group (26%, 6%,x2=21.12, P ＜ 0.005), also markedly higher in the hyperglycemia group than in the normal blood glucose group (27%, 5%, x2=21.70, P ＜ 0.005).④ Comparison of the percentage of death: It was obviously higher in the increased leukocyte group than in the normal leukocyte group (31%, 6%,x2=26.15, P ＜ 0.005), also markedly higher in the hyperglycemia group than in the normal blood glucose group (26%, 5%, x2=20.02, P ＜ 0.005). CONCLUSION: Both the increase of leukocyte and blood glucose can damage the brain tissue, and can be used to judge the disease condition of patients with acute cerebrovascular disease, estimate the prognosis and guide the treatment.

Objective To investigate the effect of glycyrrhizin(GL) on the expression of hepatitis B virus e antigen(HBeAg),hepatitis B virus surface antigen(HBsAg),HBV DNA levels and cell proliferation in HepG2.2.15 cell line.Methods HBV DNA level was examined by Real-time PCR.HBsAg and HBeAg levels were examined by ELASA,and cell proliferation was examined by MTT before and after stimulated with GL.The GL groups were compared with the blank control group.Results HBsAg levels in the GL groups were inhibited in dose-dependent manner compared with the blank control group(P

Objective:To observe the effect of “bulk-fill”flowable resin in filling deep wedge-shaped defects.Methods:50 pa-tients with totally 85 pairs of premolars with deep wedge-shaped defects(depth >2 mm)were included.Each pair of the defects was randomly divided into the test group and the control group,the defects were treated by “bulk-fill”flowable resin with single cure tech-nique and conventional flowable resin with incremental layering technique respectively,the tooth sensitive rate 1 week after filling,the filling failure rate,the edge coloring and secondary caries rate 2 years after filling of the 2 groups were compared.Results:There was no significant difference between the 2 groups in the sensitive rate 1 week after filling,the failure rate and the edge coloring and sec-ondary caries rate 2 years after filling(P >0.05).Conclusion:The “bulk-filled”flowable resin using single cure technique can ac-quire the same clinical effect as conventional flowable resin using incremental layering technique in filling deep wedge-shaped defects.

Quality control of medical equipment is very important to the diagnostic accuracy and the cure effect. The work of the quality control is the main technical basis of the hospital construction in promoting medical development, and it's also an important content of the modem medical management. The status, causes and countermeasures of medical equipment quality control in military hospital at the present time are analyzed and discussed.

By introducing the basic concept and principle, the advantages and characteristics of ASV technology are highlighted. Based on clinical application, suggestions on how to correctly set ASV parameters are given.

Objective To study the effects of several Chinese traditional medicines (CTM) on cell proliferation, cell toxicity, gene expression of Tyr and c-kit in normal melanocytes cultured from Caucasians. Methods The TRP and KIT protein expression was detected by Western blotting. The total soluble protein of melanocytes was measured by spectrophotometer by its absorption at 595nm against the standard concertration curre. Results Angelica dahurica, Fructus psoraleae, Spica Prunellae, Ligusticum chuanxiong Hort, and Eclipta Prostrasta stimulated the expression of KIT and the synthesis of total protein. The stimulating effect of Angelica dahurica and and Fructus psoraleae on the KIT expression was 69.44% and 58.43% respectively. However, these medicines only had a limited effect on the expression of Tyr in melanocytes. Conclusions The therapeutic effect of CTM on vitiligo may be related with the SCF/KIT pathway. This study might provide an useful way to screen more Chinese medicine for the treatment of vitiligo.

0.05). However, this medicine significan tly enhanced c-kit expression in melanocytes in vitro with an increase of 79.41% . Conclusions The efficacy of supplemented four agents decoction formula in th e treatment of vitiligo may be related to the SCF (stem cell factor)/c-kit pathw ay. This Chinese traditional medicine may enhance c-kit expression, but may not be associated with cell proliferation and Tyr expression of melanocytes.

Objective To study the efficacy and safety of pulse cyclophosphamide(CTX)therapy for refractory adult-onset Still's disease(AOSD).Methods Eleven patients with refractory AOSD received the treatment of intravenous pulse cyclophosphamide with 500～750 mg/m2 body surface area.The features of clinical manifestations and lab findings before and after the treatment were compared.The literatures associated with pulse CTX therapy were reviewed.Results After the first time of pulse CTX therapy,nine cases returned body temperature to normal within 72 hours,and the other two within 1week.Fever relapse was seen in five patients after the first time of pulse CTX therapy,and they returned body temperature to persistent normal after the second time of pulse CTX therapy.At the point of 1 week after the first time of pulse CTX therapy,serum C-reactive protein(CRP)significantly decreased when compared with that before treatment(P

0.05),while with significant difference in the second therapy course(P

The clinical data of 585 patients with connective tissue diseases (CTD) were retrospectively analyzed. Thyroid diseases were detected in 236 cases (40.3%) , in which the prevalence of hypothyroidism was the highest (47.9%) , followed by euthyroid sick syndrome (33.1%), Hashimoto thyroiditis (11.4%) and hyperthyroidism (5.1%) ect. Determination of thyroid function and autoantibodies to thyroid gland were essential in these patients.