Objective To discuss the medication regularity of prescriptions containing Asini Corii Colla;To provide data support for clinical compatibility application of Asini Corii Colla.Methods Totally 2635 articles about prescriptions containing Asini Corii Colla were retrieved from CNKI from Jan. 1995 to Dec. 2012. TCM Inheritance Support System V2.0 was employed to conduct frequency analysis and association rules analysis, with a purpose to determine the frequency, indications of disease, indications of syndrome and medicine core combination of common prescriptions containing Asini Corii Colla.Results The 2635 prescriptions containing Asini Corii Colla involved 1197 Chinese herbal medicines, 34 kinds of which were used in extremely high frequency (frequency>200). 30 kinds of indications of disease were treated in the high frequency (frequency>20). 32 kinds of indications of syndrome were treated in the high frequency (frequency>20). The combination of Glycyrrhizae Radix et Rhizoma, Angelicae Sinensis Radix and Asini Corii Colla showed the highest frequency in all three herbal combinations (486 times), and Atractylodix Macrocephalae Rhizoma, Asini Corii Colla, Codonopsis Radix and Astragali Radix showed the highest frequency in all four herbal combinations (272 times).Conclusion Most of compatibility them can enrich blood and tonify qi, and have major functions for gynecological diseases and major syndromes of qi-blood deficiency.