Objective To investigate and analyze the application of narcotic drugs in the our hospital from 2011 to 2013, in order to provide references for rational use of narcotic drugs in clinical practice. Methods The application da-ta of narcotic drugs in our hospital from 2011 to 2013 were collected and analyzed from the hospital information sys-tem, adverse reactions of narcotic drugs were collected from clinical pharmacy support. Results The consumption sum of narcotic drugs increased year by year. Pethidine injection and tablet consumption were the largest, morphine agents consumption were relatively stable, fentanyl and remifentanil consumption also increased year by year, narcotic drugs had different adverse reactions. Conclusion With the implementation of“three-step ladder for cancer pain” and estab-lishment of“good pain management ward”, the utilization of narcotic drugs in our hospital will be more reasonable.