BACKGROUND: Serum levels of high-sensitivity C-reactive protein (hs-CRP) can be used to predict cardiovascular injury.OBJECTIVE: To investigate the serum levels of hs-CRP in a rabbit model of atherosclerosis following repeated long-termexposure to positive acceleration and to predict the risk of cardiovascular injury.METHODS: Twenty-four New Zealand purebred rabbits were randomly divided into a positive acceleration group and a controlgroup. Rabbits in the positive acceleration group were exposed to +4 g rotation for 20 seconds with an acceleration of 1 g/s. Therotation interval was 5 minutes and totally three rotations were daily performed for 3 days per week. 0.5 g rotation was addedevery week, and by week 4, +6 g rotation was added, and the exposure lasted for 40 seconds.RESULTS AND CONCLUSION: Exposure to positive acceleration yielded significant effects on serum level of hs-CRP in rabbitswith atherosclerosis compared with before exposure (P < 0.01), but exposure time did not produce effects on serum level ofhs-CRP (P > 0.05). The interaction between exposure to positive acceleration and exposure time also did not produce significanteffects on serum level of hs-CRP (P > 0.05). Hyperplastic foam cells in the aortic tunica intima and the superficial layer of mediaincreased with the prolongation of exposure to positive acceleration. Repeated long-term exposure to positive acceleration maylead to a long-term high serum level of hs-CRP in rabbits.

Gastrointestinal stromal tumors are the most common mesenchymal neoplasms deriving from the gastrointestinal tract.The prediction of its biological behavior has become a new hot spot of the research.This article reviewed the studies on predicting the biological behavior of gas trointestinal stromal tumors.

Objective To understand the plasma Platelet Microparticiles(PMPs)level and its clinical significance in patients with type 2 diabetes mellitus(T2DM).Methods Venous blood samples were obtained from 96 of T2DM patients and 30 of non-diabetic control subjects.PMPs,CD61P positive on platelets,were quantified by flow cytometry.Meanwhile,plasma levels of PLT,FPG,TC,TG,HDL-C,LDL-C and LP(a)were detected,as well as the levels of MA and TRF from urine samples.Results PMPs counts were significantly greater in 2 year or up 2 year groups than in controls.PMPs count was associated with levels of urine MA and TRF,but not related with other indexes.Conclusion PMPs may be a marker of microvascular disease in Type 2 diabetes.

Objective To study the significance of serum IL-17 level in patients with acute coronary syndrome (ACS ) before and after rosuvastatin treatment .Methods Forty-eight ACS patients served as group A and 30 stable angina pectoris patients served as group B in this study .T heir blood-lipid level and serum hs-CRP and myocardial enzyme levels were measured and the number of coronary artery branches with lesions was calculated .Their association with serum IL-17 level was analyzed .Patients in group A were treated with rosuvastatin .The serum IL-17 levels were compared in two groups before and 4 weeks after rosuvastatin treatment .Results The serum IL-17 level was significantly higher in group A than in group B before rosuvastatin treatment (34.41 ± 6 .37 ng/L vs 15 .18 ± 3 .11 ng/L ,P<0 .05) and significantly lower in group A 4 weeks after rosuvastatin treatment than before rosuvastatin treatment (16 .71 ± 4 .72 ng/L vs 34 .41 ± 6.37 ng/L ,P<0 .05) .No significant difference was found in serum IL-17 level between the two groups after rosuvastatin treatment (P>0 .05) .Multivariate regression analysis showed that the serum hs-CRP and troponin level and the number of coronary artery branches with lesions were positively related with the serum IL-17 level (P=0 .012 ,0 .008 ,0 .000) .Conclusion Serum IL-17 level in ACS patients can partly reflect the severity of ACS .Early treatment of ACS with rosuvas-tatin can reduce the inflammatory reactions and serum IL-17 level ,and is of great significance in stabilizing the coronary plaques and reducing the incidence of ACS .

Idiopathic intracranial hypertension,which often occurs among adult overweight women,is a kind of chronic intracranial hypertension without any certain causes.The patient usually present with headache and papilloedema,and normal of brain structure and the cerebrospinal fluid composition.As visual loss is the only serious outcome,both dietary management and medical treatment are helpful in the early time,but surgery should be required as soon as visual loss occurs.The recent clinical study on idiopathic intracranial hypertension was reviewed.

[Objective]To introduce the old Chinese medicine Professor FU Weimin 's experience in diagnosis and treatment of peripheral facial paralysis. [Methods]Firstly, analyze and summarize the relevant medical records. Secondly, to briefly elaborate that the professor FU Weimin believes the overall concept ,adheres to the syndrome differentiation as a guide, and how he treats peripheral facial paralysis by syndrome differentiation.[Results]He thinks that lack of righteousness, context is empty, Wei is not solid for the fundamental pathogenesis. More importantly, vein paralysis is a pathological feature. Treatment is from the wind, sputum, blood stasis and blood deficiency and clinical medication is unique. According to the course of staging , Professor FU stresses the precise discrimination and drugs have their own characteristics. Professor insists on people-oriented and makes a significant contribution.[Conclusion]Professor FU Weimin has a systematic understanding of the pathologic mechanism of peripheral facial paralysis, syndrome differentiation and clinical experience of prescription drugs and has made a good therapeutic effect in clinical application, which is worthy of popularizing.

Objective To investigate the effect of preoperative pravastatin preconditioning on myocardial ischemia-repedusion(I／R)injury in patients undergoing cardiac valve replacement with cardiopulmonary bypass (CPB).Methods Sixty ASA Ⅱ orⅢpatients of both sexes aged 18-64 yr undergoing cardiac valve replacement under CPB were randomly divided into 4 groups(n=15 each)：control group(group C)and 3 pravastatin groups receiving oral pravastatin 10，20 and 40 mg respectively every night for 7 days before operation(group P1-3).The number of patients receiving dopamine(≥5 μg·kg-1·min-1)and adrenaline was recorded from the termination of CPB to the end of operation，from the end of operation to 12 h after operation，during 12-24 h after operation and during 24-48 h after operation.Venous blood samples were taken from central venous line for measurement of plasme cTnI and CK-MB concentrations at 7 days before operation，before induction of anesthesia，at opening of the aorta and at 2，24 and 48 h after opening of aorta.Results The number of patients receiving dopamine and adrenaline was significantly less in group P3 than in group C(P<0.05).Plasma CK-MB and cTnI concentrations were significantly lower in group P3 than in group C(P<0.05).Conclusion Preconditioning with oral pravastatin(40mg／d for 7 consecutive days)can protect myocardium against I／R injury in patients undergoing cardiac valve replacement with CPB.

Objective:To introduce a modified method for umbilical reconstruction after single-incision laparoscopic surgery.Methods:Between June 2012 and June 2015,173 patients underwent single-incision laparoscopic cholecystectomy at our institution.All the patients adopted our modified method for umbilical reconstruction.Results:All the surgeries were successful.The umbilical incision healed well with good cosmetic result.Conclusion:The modified method for umbilical reconstruction can improve cosmesis and decrease the possibility of incision hernia after single-incision laparoscopic surgery.More studies are needed to evaluate definitive clinical advantages of this technique.

Objective To explore the preoperative diagnosis and treatment of xanthogranulomatous pyelonephritis(XGP). Methods The clinical data of 16 patients with XGP from 1978 to 2003 were retrospectively reviewed, and its clinic symtoms, diagnosis and therapy were discussed in combination with literature review. Results 16 cases of patients with XGP confirmed by histopathological examination recovered well after operation, and did not relapse till now. Conclusion According to medical history, symptom, physical sign, the foam cells in urine and CT examination, XGP could be diagnosed. Sometimes, fine needle aspiration biopsy should be done in order to confirm the diagnosis of XGP. The operation was a major method for treating this disease.

Objective To investigate the effects of Hep-A and He p-B on vascular endothelial growth factor (VEGF)-induced breakdown of blood-r etinal barrier. Methods The mice were subcutaneously injected vehicle, Hep-A or Hep-B 10 mg/kg twice a day for 5 days. Then, 1 ?l of 10 -6 mol/L VEGF were intravitreous injected. After 6 hours, 13.7?10 4 Bq /g 3H-mannital were injected intraperitoneally. The mice were sacrificed and the retinas, lungs, kidneys were removed and examined for radioactivity. The result were analyzed using SPSS software to calculate and compare retina/lung and et ina/kidney leakage ratio among groups of different treatment. Result The retina/lung and retina/kidney leakage ratio were 0.38?0.04 an d 0.21?0.03 respectively in normal mice; increased significantly to 1.05?0.11 and 0.46?0.04 respectively in model mice, both P