1.Study on the Stability Evaluation of 12 Kinds of Submicro Emulsion in Market and the Test Method for the Stability
Wei CHEN ; Junzhuo ZHOU ; Wujun DONG ; Yu WANG ; Yongqi QIAO ; Guohui LI
China Pharmacy 2017;28(13):1769-1773
OBJECTIVE:To evaluate the stability of 12 kinds of submicro emulsion in market,and screen the test method for the stability. METHODS:12 kinds of submicro emulsion in market were selected,high pressure sterilization (121 ℃,30 min), high speed centrifugation(4000 r/min,15 min),accelerated test [placing 6 months under temperature of(40±2)℃,relative hu-midity of (75 ± 5)%] were conducted to investigate the pH,particle size and other indexes,and SPSS 22.0 was used to analyze the distribution variance and chi-square test,and investigate the correlation of 3 evaluation methods. RESULTS:In terms of stabili-ty investigation,the pH value of 12 kinds of submicro emulsion decreased to some extent after accelerated test,average particle size of 6 kinds of submicro emulsion samples were greater than 300 nm,the variance of the particle size distribution of 9 kinds ap-peared in 0.05-0.15,the chi-square test results of 8 kinds distributed below 1. The average particle size of 4 kinds of submicro emul-sions changed more than 10 nm after accelerated test. In terms of stability test method,Pearson chi-square progressive significance of high pressure sterilization and accelerated test was 0.665,which was higher than 0.05,indicating there was no correlation (no significance),the stability results of high pressure sterilization can not represent the results of accelerated test;that of high speed centrifugation and accelerated test was 0.004,which was lower than 0.05,indicating stability results between high speed centrifuga-tion and accelerated test results were significantly correlated. CONCLUSIONS:The submicro emulsion in market can meet the re-quirements of stability. To a certain extent,high speed centrifugation can replace the acceleration test.
2.Chemical constituents of n-BuOH extract of Comastoma pedunculatum.
Yongqi QIAO ; Baosong CUI ; Li TANG ; Jiabao LIU ; Shuai LI
China Journal of Chinese Materia Medica 2012;37(16):2360-2365
Thirteen compoumds were isolated from the n-BuOH portion of the 70% ethanolic extract of Comastoma pedunculatum by a combination of various chromatographic techniques including silica gel, macroporous adsorbent resin, Sephadex LH-20, and preparative HPLC, of which nine were triterpenoid saponins and four were flavone C-glycosides. Their structures were elucidated by spectroscopic data as saikogenin F (1), 3-O-beta-D-fucopyranosylsaikogenin F (2), clinoposaponin XV (3), saikosaponin A (4), 6"-acetylsaikosaponin A (5), clinoposaponin I (6), bupleuroside I (7) , clinoposaponin XII (8) , saikoponin b3 (9), isovitexin (10) , swertisin (11) , isoorientin (12), 3',4',5-trihydroxy-7-methoxy-6-C-beta-D-glucopyranosyl-flavone (13). Compounds 1-10, 12-13 were all isolated from Comastoma genus for the first time.
Chromatography, High Pressure Liquid
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Drugs, Chinese Herbal
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analysis
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Flavones
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analysis
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isolation & purification
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Gentianaceae
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chemistry
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Saponins
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analysis
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isolation & purification
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Spectrometry, Mass, Electrospray Ionization
3. Analysis of the effects of different nutritional support methods on postoperative recovery in patients with gastric cancer
Yongqi QIAO ; Wendi GE ; Xiaohao ZHENG ; Yibin XIE
Chinese Journal of Oncology 2019;41(5):378-383
Objective:
To assess the effects of different nutritional support methods on postoperative recovery in patients with gastric cancer.
Methods:
98 patients who received radical gastrectomy were divided into three groups: parenteral nutrition group (PN group) (