Objective To observe the therapeutic effects of Reduning combined with montmorillonite powder for infantile viral enteritis. Methods A total of 136 patients with infantile viral enteritis in Shanxi Tongchuan Mining Bureau Central Hospital pediatric clinic from August 2010 to October 2013 were selected and divided into two group by random number table method, a Reduning group (65 cases) and a combined treatment group (71 cases). The Reduning group was treated with Reduning injection and the combined treatment group was treated with Reduning injection plus oral montmorillonite powder. The total efficiency, improvement of symptoms and staying hospital time were compared between the two groups. Results The total effective rate in the combined treatment group was significantly higher than that in the Reduning group (97.1% vs. 59.9%, χ2=28.696, P<0.05). The fever clearance time (2.96 ± 1.32 d vs. 3.84 ± 1.94 d; t=2.587, P=0.011), the time to stop diarrhea (3.12 ± 1.44 d vs. 3.95 ± 1.97 d;t=2.340, P=0.022) and staying hospital time (4.60 ± 1.62 d vs. 5.86 ± 2.35 d;t=3.044, P=0.003) in the combined treatment group were all shorter than those in the Reduning group. Conclusions Reduning combined with montmorillonite powder is more effective in the treatment of infantile viral enteritis than Reduning alone, which shortens the course and staying hospital time.