Objective To explore the clinical effect of postoperative early enteral nutrition in the elderly patients with total gastrectomy. Methods Fifty seven elderly patients with total gastrectomy were divided into postoperative routine nutrition(PRN), postoperative early parenteral nutrition(PEPN), and postoperative early enteral nutrition(PEEN) groups. The levels of serum albumin(ALB), transferrin(TF), pre-albumin(PA), CD3, CD4, CD8, CD4/CD8 were detected 1 day before(PRED 1 ) and 9 days after(POD 9 ) operation, and the postoperative infectious complications were observed , and the length of hospital stay(LOS) and the cost of nutritional support were determined. Results The levels of ALB, TF, PA, CD3, CD4 and CD4/CD8 on POD 9 were (34.3?3.5)g/L, (1.7?0.2)g/L, (258.8?20.2)mg/L,(39.7?5.4)%,(34.3?4.0)% and (1.5?0.3) in PEPN as well as (33.9?3.1)g/L, (1.7?0.2)g/L, (260.5?24.7)mg/L, (42.8?6.5)%, (37.2?4.5)% and (1.7?0.2) respectively, which were all significantly lower than (29.5?3.0)g/L, (1.3?0.2)g/L, (235.4?13.9)mg/L, (34.8?5.0)%, (30.4?4.4)% and (1.2?0.2) in RN group (all P

Objectives:To observe the influence of glutamine supplemented TPN on surgical patients. Methods:Thirty cases were randomly divided into two groups.One was glutamine supplemented TPN group(Gln TPN) and another group was standard TPN group (S TPN). Results:①Total lymphocyte count(TLC) was raised significantly in Gln TPN than in S TPN.②There were no differences in hepatic function,Hb and ALB between two groups.③There was no difference in recorery of intestinal function between two groups.④The patients recovered more rapidly from POF in Gln TPN group than in S TPN group. Conclusions:Glutamine supplemented TPN could increase TLC of surgical patients and remit POF more rapidly.

Interferon-induced Transmembrane Proteins (IFITMs) were identified through small interference RNA (siRNA) screening method in 1980s. The antiviral properties of the IFITMs were firstly discovered in 1996. Recently, its antiviral effect and mechanism have become a research hotspot. Many studies have shown that IFITM can inhibit the replication of multiple pathogenic viruses, including influenza A virus (IAV), Human Immunodeficiency Virus (HIV-1), hepatitis C virus (HCV), Ebola virus (EBOV), West Nile virus and so on. IFITMs inhibit the replication of virus in the early stage of the viral life cycle, which occurred before the release of viral genomes into the cytosol. Recent studies indicate that IFITM proteins could block viral replication by mediate viral membrane fusion. However, the mechanism is still under investigation. Here we review the discovery and characterization of the IFITM proteins, elucidate their antiviral activities and the potential mechanisms.
Animals ; Humans ; Interferons ; genetics ; immunology ; Membrane Proteins ; genetics ; immunology ; Virus Diseases ; genetics ; immunology ; virology ; Viruses ; genetics ; immunology

Objectives:To investigate the effect of growth hormone(GH) and parenteral nutrition (PN) on protein metabolism in patients with cirrhosis of liver. Methods:The test group received GH and PN,and the control group received PN only.All the treatments were maintained for 7 days.The serum levels of Alb,TFN and PA were detected on the day before the treatment and the day 3,5 and 7 after the treatment. Results:As compared with the day before the treatment,the levels of Alb,TFN and PA on the day 3,5 and 7 in the two groups were all increased.However,the changes in the test group were greater than those in the control group.As compared with the control group,the level of Alb on the day 7 and the levels of TFN and PA on the day 5 and 7 in the test group were significantly higher. Conclusions:The therapeutic value of combined use of GH and PN is much better than that of single PN in patients with cirrhosis of liver.

Objectives:To investigate the effect of GH added early postoperative enteral nutrition on protein metabolism and immune function. Methods:Thirty six patients undergoing total or subtotal gatrectomy were randomly divided into three groups:traditional entertal nutrition (TEN),early postoperative enteral nutrition(EPEN),and GH added early postoperative enteral nutrition(GH+EPEN).Nutritional support lasted for 7 days.GH daily dose was 8 IU.Nutritional markers and immune markers were detected in several time points. Results:On postoperative day 4,the levels of Alb,Tf,TCL,and CD4/CD8 were all significantly increased in GH+EPEN as compared with those of TEN(all P

Objectives:To investigate the therapeutic effect of somatostatin and parenteral nutrition on early postoperative inflammatory intestinal obstruction. Methods:16 patients(test group) were treated with somatostatin and parenteral nutrition.Somatostatin was administered in 6 mg doses daily through continuous intravenous drip and the formula of parenteral nutrition was provided according to clinical routines.The therapeutic effect was compared with that of previous 13 cases(control group) without use of somatostatin and parenteral nutrition. Results:The rates of transferring to operation in the test group and the control group were 12.5 % and 61.5%( P

OBJECTIVE To investigate the risk factors and to take some useful measures to prevent and reduce infection in order to enhance medical quality,to ensure medical security,to strengthen hospital infection manangement and to prevent hospital infection effectively. METHODS We investigated the prevalence rate of hospital infection among our hospitalized patients in 2001,2003 and 2005, respectively. RESULTS The hospital infection rate was 4.6-6.42% in these years.Risk factors and the abuse of antibiotic were decreasing. CONCLUSIONS In order to control hospital infection rate,mensures should be taken including intensively monitoring the departments with high infection rate,strengthening hospital operation,rationally using the antibiotics,and studying the management for hospital infection.

OBJECTIVE:To study the effects of Buyang huanwu decoction on the contents of CD40 and CD40L in the serum of rats with cerebral ischemia. METHODS:Rats were randomized into a sham-operation(normal saline)group,a model(normal saline)group,a positive control [6.75 mg/(kg·d)clopidogrel hydrogen sulfate] group and Buyang huanwu decoction high-dose and low-dose [26 and 6.5 g/(kg·d)] groups,with 20 rats in each group. Suture occlusion of middle cerebral artery was used to establish the rat models of focal cerebral ischemia,which were given drugs ig on the 2nd day after the operation and for 14 consecutive days. Then pathological changes in the cerebral tissues of all groups of rats were observed and the contents of CD40 and CD40L in the serum thereof were detected by euzyme-linked immunosorbent assay. RESULTS:The rats in the model group demonstrated isch-emia-like pathological change in the cerebral tissue on the side of lesion. The ischemia-like cerebral tissue on the side of lesion in the positive control group and Buyang huanwu decoction high-dose group were improved compared to the model group. The patho-logical change in the cerebral tissue on the side of lesion in Buyang huanwu decoction low-dose group was similar to that in the model group. The contents of CD40 and CD40L in the serum of rats in the model group were higher than in the sham-operation group. The content of CD40L in the serum of rats in positive control group and Buyang huanwu decoction high-dose group were lower than the model group. There were statistical differences(P<0.01 or P<0.05). Except as described above,no other statistical-ly significant differences (P>0.05) were noted. CONCLUSIONS:Buyang huanwu decoction can improve brain cell morphology and reduce cerebral ischemic tissue injury in model rat with cerebral ischemia by a mechanism which may be related to decreasing the content of CD40L.

ObjectiveTo evaluate the feasibility,safety and therapeutic efficiency of laparoscopic total mesorectal excision (TME) with anal sphincter preservation in the treatment of the middle-lower rectal cancer.MethodsFrom February 2008 to June 2010,37 patients with middle-lower rectal cancer received laparoscopic TME with anal sphincter preservation,while 45 patients underwent conventional open TME with anal sphincter preservation according to their wills.The operative procedures,postoperative recovery,postoperative complication and short-term outcome were collected and compared between the two groups.ResultsBlood loss was (60.6 ± 20.9) mL in laparoscope group which was significantly less than that in laparotomy group (P＜0.01),time for bowel movement retrieval and hospital stay were (3.3 ±0.6) and (9.2 ±2.8) days respectively,which were significantly shorter than those in laparotomy group (P ＜ 0.01 ).The incidence of postoperative complications was 8.1％ in laparoscope group,which was significantly lower than those in laparotomy group (P ＜ 0.05 ).The mean distance between resected margin and the tumor,the mean number of disected lymph nodes were not different between the two groups.The rate of sphincter preservation was 91.9％ in laparoscope group,which was higher than those in laparotomy group (73.3％) ( P ＜ 0.05 ).All patients were followed-up from 6 to 36 months,the recurrent rate and overall survival rate were 10.8％ and 94.6％ in laparoscope group,with no significant difference compared to those in laparotomy group (11.1％ and 91.1％,P ＞ 0.05).ConclusionsLaparoscopic TME with anal sphincter preservation which achieved the same effect of oncological clearance is a safe and feasible procedure for middle-lower rectal cancer,with less postoperative complications and better recovery after treatment,and enhances the rate of sphincter preservation,which is worthy of clinical application.

Objective To investigate the efficacy of endovascular stenting complicating other craniocervical artery stenosis (OCAS) in patients with atherosclerotic subclavian artery stenosis/occlusion (SASO).Methods The clinical data of receiving endovascular stenting therapy in patients with atherosclerotic SASO were analyzed retrospectively,including demographic characteristics,vascular risk factors,complicating OCAS,as well as stenting for SASO and follow-up results.Results A total of 65 patients with SASO were included in the study,47 of them were males and 18 were females (mean age of 64 ± 9 years).Forty-six patients (70.8％ ) complicated OCAS.The overall technical success rate was 95.4％,in which the patients with stenosis (n =58) were 98.1％ and those with complete occlusion (n =7) were 71.4％.The complications occurred in 4 patients.There were no intervention-related serious stroke and death.Mean follow-up was 24 ± 19 months,6 patients with restenosis and 10 with clinically relevant events were found.They mainly occurred in patients with OCAS.The first angioplasty patency rates were 94.5％,81.8％ and 81.8％,respectively at 12 and 24 months after procedure and at the end of follow-up.The survival rates of no clinically relevant events were 92.9％,74.6％ and 68.3％,respectively.Conclusions Endovascular stenting can safely and effectively treat the SASO patients complicating OCAS.Its overall clinical outcome may be affected to some extent by OCAS.