The experiment was performed at Basic Medical College and First Affiliated Hospital, Zhengzhou University from September 2004 to December 2005. Totally 60 Kunming mice were divided into 5 groups randomly: ①blank control group (n =15) and simple radiation group (n =15). The mice were given 0.2 mL sterile saline by intraperitoneal injection. ②antineoplastic polypeptide from Buthus Martensii Venom (APBMV) group (n =10) and APBMV plus radiation group (n =10) received 0.2 mL APBMV according to prepared concentration by intraperitoneal injection. ③Katsutoxin extract Ⅲ plus radiation group (n =10) received 0.2 mL katsutoxin extract Ⅲ by intraperitoneal injection every other 5.5 hours for 7 days. After 24 hours from the last injection, the mice were endured 60Co g ray radiation (80 cm, 7.5 Gy irradiation dose, 0.27 Gy/min dose rate). Then katsutoxin extract Ⅲ was given same as above for 7 days. Then bone marrow was extracted to be cultured to colony-forming unit-granulocyte and monocyte (CFU-GM). The findings showed that colony amount of APBMV plus radiation group and katsutoxin extract Ⅲ plus radiation group was obviously more than that of simple radiation group [(32?5),(27?3),(2?1)pieces/well,P

Objective:To evaluate efficacy and safety of multiple-dose tropisetron plus dexamethasone (DXM) versus palonosetron plus DXM for chemotherapy-induced nausea and vomiting. (CINV) in patients received multiple day-based highly emetogenic chemotherapy. Methods:Cancer patients who were receiving multiday-based highly emetogenic chemotherapy were randomly assigned to AB or BA groups. A randomized, cross self-control ed method was applied. Patients in AB group received palonosetron (0.25 mg) 30 min before chemotherapy on day 1 and 3 or additional day 5 in the first cycle;and with tropisetron (5 mg) 30 min before chemotherapy on day 1, 2, and 3, or sup-plementary days (day 4 and 5) in the second cycle. Patients in BA group were treated with tropisetron in the first cycle and with palonosetron in the second cycle. Tropisetron and palonosetron were administered with DXM (10 mg) on day 1, followed by additional doses (5 mg) on days 2 to 5. Palonosetron group comprised patients in the AB group in the first cycle and BA group in the second cycle, whereas tropisetron group included patients in the AB group in the second cycle and BA group in the first cycle. Efficacy and safety of tropisetron versus palonosetron in preventing CINV were evaluated. Results:Ninety-one patients were included in analyses. At day 3, 4, and 5, incidence rates of nausea in the palonosetron group reached 28.6%, 30.8%, and 24.2%, respectively, and those of the tropisetron group totaled 42.8%, 47.3%, and 39.6%, respectively (P<0.05). At day 4, 5, and 6, incidence rates of vomiting in the palonosetron group measured 28.6%, 18.7%, and 5.5%, respectively, and those of the tropisetron group reached 42.9%, 34.1%, and 14.3%, respectively (P<0.05). From day 4 to day 5, day 6 to day 7, and day 1 to day 7, the palonosetron group yielded significantly lower incidence rates of nausea and vomiting than tropisetron group (P<0.05). Rate of rescue treatment in the palonosetron group was lower than that in tropisetron group (13.2%vs. 24.2%, P=0.057). No statistical difference in toxicities was observed between the two groups. Conclusion:Palonosetron plus DXM features better efficacy than that of tropisetron plus DXM against delayed CINV induced by multiple day-based highly emetogenic chemotherapy, which was well tolerated in the two treatments.

Objective To investigate the long-term quality of life ( QOL ) in the patients after percutaneous coronary intervention (PCI) and to explore its influencing factors in order to provide the basis for clinical nursing and health education .Methods A total of 1 028 patients with PCI from June 2012 to May 2013 were surveyed by the CROQ-PTCA-Post, and the results were analyzed .Results The average score of long-term QOL in patients with PCI was (69.58 ±7.97), and the scoring rate 69.6%.The scoring rates of different dimensions from high to low were respectively 97.3% ( adverse reactions ), 77.1% ( cognitive function ), 68.5%(treatment satisfaction), 60.3%(physical function), 58.9% (symptoms), 55.5% (psychological and social function ) .The one-way ANOVA showed that the differences were found between the total score of QOL in patients at the different stages after the operation and the scores of four dimensions including symptoms , physical function, psychological and social function , treatment satisfaction (P <0.01).Conclusions The long-term QOL in the patients after PCI is generally lower , and the various types of health education should be pertinently carried out , and the social support system should be fully mobilized , and the postoperative follow-up system should be improved in order to increase the long-term QOL in the patients .

Objective To evaluate the effects of transitional self-management intervention on patients after percutaneous coronary intervention ( PCI ) .Methods One hundred PCI patients were assigned into the control group (50 cases) and the intervention group (50 cases) according to draw method.The control group was treated with the cardiology conventional health education .The intervention group was treated with the self-management model and the transitional nursing model .The coronary artery self-management scale ( CSMS) was used to compare between the groups at one month and six month after PCI .Results There was no significant difference in the score of CSMS before the investigation (P>0.05).After one month of intervention, the score of daily management , disease management and emotional cognition of the intervention group were ( 48 .17 ± 7.20), (46.43 ±5.66) and (47.96 ±9.69), respectively, which were significantly higher than (30.68 ± 8.51), (33.40 ±4.86) and (22.44 ±8.56) in the control group, the difference was statistically significant (t=10.539, 10.767, 13.221, respectively;P <0.01).After six month of intervention, the score of daily management, disease management and emotional cognition of the intervention group were (58.83 ±6.16), (65.30 ±5.28) and (61.55 ±8.23), respectively, which were significantly higher than (30.68 ±8.51), (28.45 ±5.07) and (24.00 ±7.25) in the control group, the difference was statistically significant (t =18.373, 33.822, 22.929, respectively;P <0.01).After one month of intervention, the self-management knowledge and behavior of the intervention group were significantly better than the control group , the difference was statistically significant (P <0.05).At one month, the daily management, disease management and behavior of the control group was significantly improved , the difference was statistically significant (P<0.05).However , the score of disease management at six month after the intervention was significantly decreased compared with that at month, the difference was statistically significant (P<0.05).Conclusions Comparing with the conventional health education , the transitional self-management intervention is effective , and it is worthy of getting widely extension in hospital .