Moyamoya disease is a cerebrovascular disease that is characterized by the progressive stenosis in the terminal internal carotid artery, the anterior cerebral artery and the origin of the middle cerebral artery, and compensatory enlargement of basal perforating artery. Both the genetic and environmental factors involxe in its pathogenesis. but its exact cause is unknown. Revascularization is the main treatment approach for moyamoya disease. This article reviews the progress in research on epidemiology, etiology, diagnosis and treatment of moyamoya disease.

Objective To evaluate the technical success,adverse events in 30 days after endovascular repair for acute and non-acute Stanford B aortic dissection.Methods A search was performed to identify all Chinese literatures that compare the effect of TEVAR on acute and non-acute Stanford B dissection in WanFang and Chinese National Knowledge Infrastructure (CNKI) from 2009 to 2014.Literatures were extracted and x2 test conducted by SPSS 17.0 software,REVMAN 5.3 software was used to conduct meta-analysis and bias analysis by STATA software.Results 5 studies including 468 patients (acute group 243,non-acute group 225) were extracted.Acute Stanford B dissection have higher rate both in total complications(OR =3.10,95％ CI =[1.74,5.53],P =0.0001) and endoleaks (OR =2.07,95％ CI =[1.11,3.88],P =0.02) within 30 days than non-acute group,the technique success rate (P =0.3),the mortality rate within 30 days (P =0.27) as well as aortic related mortality rate (P =0.26)show no significant difference.Conclusion Acute Stanford B dissection have higher rate of total postoperative complications,endoleaks within 30 days than non-acute group,with similar surgical success rate,30 days mortality rate and aorta related mortality rate.

Objective To explore the effect of lipide on mice podcyte prolixferation in vitro culture.Methods MTT was used to dectect the change of the Podocyte Proliferation after the inducement of low-density-liportein(LDL)and oxide-LDL(OX-LDL).Results After 24 and 48 hours,the mice podocyte proliferation increased with the inducement of LDL,which the thickness from 6.25?g/ml to25?g/ml.And after 24 hours,the podocyte proliferation increased with the OX-LDL,which the thickness from 12.5?g/ml to 100?g/ml(compared with control,P

Objective To study the efficacy of electroacupuneture combined with auricular acupoint seeds on cluster headache and its adverse reaction interfering.Methods A total of 98 cases with stroke were randomly recruited into a control group of 49 cases and a treatment group Of 49 cases.The control group was treated with conventional medicine,while the treatment group was treated with electro-acupuncture combined with auricular acupoint seeds,besides tge conventional intemal medicine.The efficacy was evaluated after one monm's treatment.A follow-up efficacy was evaluated in the continuous 6 months.Results 2 cases in the treatment group and 1 case in the control group quitted in the process.The treatment group showed significant better results in the immediate efficacy,3-mortth follow-up efficacy and 6-months follow-up efficacy as compared to the control group(all P＜0.05).The adverse reaction incidences of the treatment group were also significantly lower than the control grouD at 3-months and 6-months follow-up study(all P＜0.05).Conclusion The therapy of electro-acupuncture combined with auricular acupoint seeds is helpful to improve pharmacotherapy effect and alleviate medium term and long term adverse drug reaction.It can be served as an effective preventative measure for cluster headache.

Objective To investigate the possible mechanism of recombinant human erythropoietin (rhEPO) neuroprotection by studying the effect of rhEPO on expressions of matrix metalloproteinase-9 (MMP-9) and BCL-2 following focal cerebral ischemia-reperfusion in rats. Methods A rat middle cerebral artery occlusion/reperfusion (MCAO/R) model was induced by the intraluminal filament method, and intraperitoneal injection of rhEPO was used for intervention. Histopathological changes were observed by HE staining, and the expressions of MMP-9 and BCL-2 in the cerebral cortex of ischemic side were detected with immunohisto-chemistry. Results HE staining: At all time points, the numbers of surviving nerve cells were significantly higher in the rhEPO group, and their injury degree was significantly lower. MMP-9 immunohistochemistry staining: The positive cells were observed occasionally in the normal control group and the sham-operation group; the MMP-9 positive cells at the ischemic side of brain tissue in a normal saline control group began to appear at 6 hours after reperfusion, it reached the peak at 24 hours and began to decrease at 72 hours; the change trend of MMP-9 positive cells in the rhEPO group was similar to that in the normal saline control group, but it was significantly lower than that in the normal saline control group at the same time points (t were 12. 023 6, 12. 635 0, 12. 779 6, respectively, all P <0. 01). BCL-2 immunohistochemistry staining: No positive cells were found in the normal control group and sham-operation group. The numbers of BCL-2 positive cells reached the peak at the ischemic side of brain tissue in the normal saline control group at 6 hours after reperfusion, it reached the peak at 24 hours and further decreased at 72 hours; the change trend of BCL-2 positive cells in the rhEPO group was similar to that in the normal saline control group, but it was significantly higher than that in the normal saline control group at the same time points (t were 5. 763 1,8. 110 1, and 5. 798 7, respectively, all P <0. 01). Conclusions rhEPO may inhibit cortical neuronal apop-tosis at the ischemic side by inhibiting MMP-9 expression and up-regulating BCL-2 expression so as to play a neuroprotective effect.

The proteomics definition, investigation method and its a pplication in cancer research were simply introduced. Proteomic research is to r eveal the function of genes from an integrated, kinetic and quantitative view at the global protein level, which is an important component of post-genome proje ct. Cancer is a kind of complex disease involved by multi-genes. Proteomic rese arch will be helpful to discover the mechanism of cancer development, to find sp ecial malignant tumor markers and targets of drug treatment.

Objective To evaluate the efficacy of total glucosides of paeony(TGP) in the treatment of undifferentiated spondyloarthropathies(uSpA) and investigate its mechanism.Methods One hundred and sixteen cases of uSpA were randomly assigned to 2 groups,one group was treated with TGP and diclofenac sodium,the other group with SASP and diclofenac sodium.The efficacy and side effects of the two groups were compared after 12 weeks treatment.The level of IL-6,IL-10 and TNF-? was determined at the same time.Result After 12 weeks treatment,the major clinical manifest and the indexes of disease activity were no difference of statistical significance in the two groups.The incidence of parenterally side effects was 8.6% in TGP group,and 25.9% in SASP group.There was difference at statistical significance between the two groups(? 2 =6.042,P=0.014).Before treatment,the level of IL-6,IL-10 and TNF-? in the serum of two groups were no statistical difference,while there was obviously difference after 12 weeks treatment(t= 2.672,2.483 and 2.088,P=0.009,0.014 and 0.039).Conclusion The efficacy of TGP and SASP has no significant difference in the treatment of uSpA.But the incidence of parenterally side effects in the TGP group was less than SASP group.The mechanism of efficacy of TGP may be related to inhibiting the production of IL-6,IL-10 and TNF-?.

Objective To investigate the expression of NF-?B,TNF-?,ICAM-1 in rat's brain tissue and the sequential changes of serum IL-1?,IL-6,IL-10 after focal cerebral ischemia-reperfusion,and to observe the influence of the Shenxiong Injection.Methods Fifty-four male rats were randomly divided into control,Ligustrazin-treated and Shenxiong-treated group.Rats models of focal cerebral ischemia-reperfusion(I/R)were made by using suture.Drew back sutures 1 hour after the blood supply were blocked.A series of brain and blood samples were obtained directly 6,12 and 24 hours respectively after reperfusion in three groups.The expression of NF-?B,TNF-? and ICAM-1 in the brain tissue was determined by immuno-histochemical method.Serum levels of IL-1?,IL-6 and IL-10 were measured by enzyme linked immunosorbent assay (ELISA).Results As time of I/R prolonged,the expression of TNF-?,ICAM-1 upregulated,but NF-?B reached the maximum at R12 h in three groups.Compared with control group,expression of NF-?B,TNF-?,ICAM-1 in Shenxiong-treated group decreased significantly(P

Objective:To develop a scale used to measure smoking-related attitudes in Chinese secondary school students. Methods:Based on literatures published in China and abroad and suggestions by relevant specialists and teachers, we developed a self-administered scale with 16-item used to measure smoking-related attitudes in Chinese secondary school students. Factor analysis was used to assess the construct validity of the scale. The differences of the scores between trying smokers and non-smoker, and males and females were tested for assessing the discriminant validity of the scale. Cronbach's alpha for the total scale and the sub-scales was calculated for evaluating the internal consistency, and the split-half reliability test analysis was also conducted. Moreover, 112 subjects were re-investigated after two weeks of the first survey, and the difference and correlation of scores between the two surveys were tested for assessing the stability of the scale. Results: Factor analysis identified two potential components that could explain 46.2% of the total variance, and the first factor including 9 items was defined as "The opinions to tobacco and smoking-related behaviors", and the second one including 7 items was defined as "The opinions to measures for preventing and controlling smoking". The mean score of the scale in non-smokers was significantly higher than that of the trying smokers, while the mean score in females was significantly higher than that in males. The Cronbach'? coefficient was 0.87 for Factor One, 0.75 for Factor Two, and 0.86 for the general scale, and the coefficient of the split-half reliability was 0.71 for Factor One, 0.59 for Factor Two, and 0.72 for the general scale. By analyzing the data of 112 students who participated in both surveys, we obtained test-retest reliability of factorⅠas 0.72, of factor Ⅱ as 0.44 and of all items as 0.67, and all the correlation coefficients were statistically significant. There were no differences for the scores of the scale between the two surveys. Conclusion: The results indicated that the smoking-related attitude scale had reasonable validity and reliability,It could provide valuable reference for future similar surveys in China.

Experimental studies and clinical practices have found that mild hypothermia has neuroprotective effects. However, its specific mechanism is unclear. Although its efficacy is questioned continuously, mild hypothermia technique is still widely used in the intracranial aneurysm surgery for reducing ischemic injury in recent years. Currently its safety, effectiveness and methods are the focus of studies. The article reviews the recent progress in this field.