In this review, the concept and idea of chemical modeling and model population analysis ( MPA) were introduced, and the recent applications of MPA-based methods to different aspects of chemical modeling were listed, including outlier detection, variable selection, model evaluation and applicability domain. In addition, the feasibility and applicability of MPA to different kinds of dataset was illustrated, such as near infrared spectroscopy, quantitative structure-activity relationship and metabolomics, which provided a better idea and framework to develop a new algorithm in chemical modeling.

Objective:To explore the application value of scenario simulation teaching combined with two-way evaluation in standardized training of pediatric nursing.Methods:A total of 34 trainees who received standardized training of pediatric nursing in The First Affiliated Hospital of Air Force Medical University from March 2018 to March 2019 were selected as the control group, and another 42 trainees from April 2019 to July 2020 were selected as the study group. The control group used traditional teaching, and the study group used scenario simulation teaching combined with two-way evaluation. Theoretical examination and scenario simulation exercise examination were used to assess the theoretical knowledge and clinical practice ability of the trainees, and questionnaire survey was used to evaluate the satisfaction of the trainees with the teaching effect. SPSS 22.0 was used for t-test. Results:The scores of theoretical examination[(95.12±6.24) vs. (91.05±5.12)] and scenario simulation exercise examination (nursing practice skill operation ability, ability to combine theory and practice, clinical thinking and judgment ability, emergency handling ability, communication ability, humanistic care and professional learning ability, and work attitude) of the trainees in the study group were higher than those in the control group, and the differences were statistically significant ( P<0.05). The satisfaction evaluation of the trainees in the study group with the teaching effect was higher than that in the control group, and the difference was statistically significant ( P<0.001). Conclusion:Scenario simulation teaching combined with two-way evaluation can improve the theoretical knowledge, clinical practice ability, and teaching satisfaction of pediatric nursing trainees.

Objective To cultivate and breed laboratory cats in conventional laboratory animal facilities, collect background data on laboratory cats, and compare them with purchased domestic cats to assess the feasibility of breeding laboratory cats. Methods Indigenous cat breeds were introduced for reproduction and population expansion under conventional laboratory environment, with recording of kitten survival rates and growth curves. Indicators of 20 laboratory cats of F1 generation (half male and half female), including complete blood count, blood biochemistry, organ mass, organ coefficient, heart rate, and blood pressure, were detected and comparisons between sexes were made. Blood pressure values and sensitivity to histamine of these cats were measured using depressor substance detection method in the Pharmacopoeia of the People's Republic of China-Four Parts: 2020, and were compared with the data from 173 concurrently purchased domestic cats. Results Laboratory cats adapted well to the environment of conventional laboratory facilities, with a survival rate of 77.08% of kittens at 8 weeks of age. Red blood cell count, hemoglobin content, mean corpuscular hemoglobin concentration, and hematocrit in male laboratory cats were significantly higher than those in females (P<0.01), while the mean corpuscular volume in males was significantly lower than that in females (P<0.01). The levels of serum alanine aminotransferase, total bilirubin, creatinine, triacylglycerol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in male laboratory cats were significantly higher than those in females (P<0.05 or P<0.01), while cholesterol, globulin, total protein, and the albumin-globulin ratio were significantly lower in males (P<0.01). The liver coefficient in male laboratory cats was significantly lower than that in female cats (P<0.05), while the kidney coefficient was significantly higher (P<0.05). The spleen-brain and kidney-brain ratios were significantly higher in males compared to females(P<0.05 or P<0.01). No significant differences were found in heart rate, systolic pressure, diastolic pressure, mean blood pressure, or sensitivity to histamine between male and female laboratory cats (P>0.05). Compared to laboratory cats, purchased domestic cats had significantly higher heart rate, systolic pressure, and mean blood pressure (P<0.01), and the magnitude of blood pressure changes induced by medium and high doses of histamine was significantly reduced (P<0.05 or P<0.01). Conclusion It is feasible to breed laboratory cats in conventional laboratory animal facilities. The accuracy of experimental results can be improved by using laboratory cats with clear and standardized background data.