60 years senile autopsy cases w as about half of that of western countries,most of latent carcinomas were well a nd moderate differentiated.HGPIN was closely associated with prostatic adenocar cinoma.

Radiotherapy after breast conserving surgery for breast cancer is an important part of comprehensive therapy,and breast conserving surgery combined with radiotherapy for early stage breast cancer has been widely recognized.Modern radiotherapy techniques including three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) have obtained reasonable application in breast conserving therapy.Radiation reaction and cosmetic result are important factors to evaluate radiotherapy after breast conserving surgery.Radiation reactions and cosmetic results of different radiotheraies are different and each has its own characteristics.

Pregnancy associated breast cancer (PABC) has many special characteristics,such as the clinical manifestation,pathology,diagnosis,treatment and prognosis.Due to the delay of diagnosis,the survival rate is low and the prognosis is poor.Early diagnosis and comprehensive individualized treatment with operation,radiotherapy and chemotherapy are needed to improve the prognosis of patients and prolong the survival period.

18 F-FDG PET-CT has been widely used for the diagnosis,staging and assessment of therapeutic response in patients with non-small cell lung cancer (NSCLC).In particular,the technique plays an important role in the prediction of the response to therapy in patients with locally advanced NSCLC.It can dynamically observe the tumor tissue metabolism,and according to the changes of 18 F-FDG uptake by visual or quantitative analysis,before and after treatment,allow prediction of the early efficacy of locally advanced NSCLC with chemotherapy and (or) radiotherapy in clinical or sub-clinical levels.

Objectives To investigate the regularity of fluctuation and clinical senses of serum c reactive protein (CRP) level in patients with acute cerebral infarction (ACI) Methods 100 subjects (56 males and 44 females) were divided into five groups including 24 large artery arteriosclerosis (LAA), 27 small artery occlusion (SAO), 2 cardiac embolism(CE), 34 other Certain(OC) and 13 undetermined etiology according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Through enzyme linked immunoabsorbent assay (ELISA), we detected and analyzed CRP levels of 100 inpatients Results The risk factors of stroke included coronary heart disease , hypertension, diabetes and intoxication of CO and so on Among the above mentioned, the level of CRP and rate of positive CRP of patients who poisoned by CO was the highest That of coronary heart disease group was lower However, there was no notable difference between hypertension and diabetes groups Conclusions CRP may play a certain role in the occurrence and development of ACI It represents different levels in different types of stroke

Computer-administered neurobehavioral evaluation system (NES)was developed based on the neurobehavioral core test battery (NCTB)recommended by WHO/NIOSH in 1985. Compared with NCTB,the reliability and validity of NES was much improved and some disadvantages of NCTB were made up in NES. This article reviewed the history of NES development,its application in the evaluation of children's neurobehavioral functions and its defects. The studies suggested that some items of NES test,such as finger tapping,continuous performance test and hand-eye coordination,could be used to evaluate earlier damage induced by chemicals on neurobehavioral functions of children.

[Objective]To evaluate the usability of endoscopy for the diagnosis of rhinorrhea.[Methods]An analysis was made on the rhinorrhea figure and letter data among 100 cases undergone endoscopy via the route of nasal cavity.All the cases were diagnosed as rhinorrhea.[Results]All of the cases were seen turbinates tumescence or mucous hyperemia and edema changes.Different changes reflected asthenia or sthenia of the 4 types of syndrome.[Conclusions]It is very valuable for combining endoscopy with TCM in the diagnosis with syndrome differentiation of rhinorrhea.

Objective: To explore the differential expression of tumor associated antigen CA X in tumor cells in vitro and in vivo . Methods: Tumor xenografts of the human lung adenocarcinoma cell line SpcA1 were grown in athymia mice. The antigen was measured before and after xenograft by Western blotting and flow cytometric analysis. Results: The antigen CA X was a glycoprotein with a molecular weight of 170 000 to 200 000 . Human lung adenocarcinoma cell lines regain expression of antigen CA X when xenografted into athymia mice. Conclusion: These data indicate that CA X synthesis in human lung adenocarcinoma cells SpcA1 is regulated by factors presented only in the xenograft.

To investigate the mechanism of low responsiveness of cultured human intestinal epithelial cells (IECs) to LPS stimulation, IL-8 secretion level was detected by ELISA in supernatants harvested after the IECs were treated with LPS for 18h, and TLR4, TLR2, CD14 and MD2 mRNA were detected by reverse transcriptase-polymerase chain reaction(RT-PCR) and RNase protection assay(RPA). It was found that IL-8 was not detectable after IECs were treated with LPS and the expression levels of TLR4, TLR2, CD14 and MD2 mRNA of IECs were low and after exposed to LPS, the expressions of TLR4, CD14 and MD2 mRNA of IECs became further lower, whereas the expression of TLR2 mRNA didn't change obviously. The result suggests that low expressions of LPS signal transduction-associated receptors on IECs may be responsible for low response of IECs to LPS, so it confirms further that TLR4, CD14 and MD2 play important roles in transmembrane LPS signal transduction.

Objective:To investigate the eye movement anormalities of Obsessive-Compulsive Disorder (OCD) and their possible clinical significances. Methods: Exploratory eye movement in 57 patients with OCD according to DSM-IV criteria (27 medicated, 30 un-medicated) and 50 normal controls matched with sex, age and education were examined respectively. Results: Compared with normal controls, patients with OCD demonstrated low scores in most of the indices of exploratory eye movement. The rates of positive discrimiant score in OCD and normal controls were 37%(21/57) and 8% (4/50), respectively (X2 = 12.27, P