1.Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer
Zhe CHEN ; Xiaofeng ZHAI ; Yonghua SU ; Xuying WAN ; Jin LI ; Juemin XIE ; Bo GAO
Journal of Integrative Medicine 2003;1(3):184-6
OBJECTIVE: To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer (PLC). METHODS: One hundred patients with moderate and advanced PLC were randomly divided into cino-treated group (50 patients) and control group (50 patients). The quality of life, tumor size, some changes of laboratory tests, and survival time were observed. RESULTS: The progressive rate of cino-treated group (18%) was lower than that of the control group (32%). The quality of life of the cino-treated group (80%) was better than that of the control group (72%), but without statistical significance. The survival rate of >12 months of the cino-treated group (30%) was higher than that of the control group (18%). The patients' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group. The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group. CONCLUSION: Cinobufacini injection can not only inhibit the proliferation of cancer, but also protect liver function, improve quality of life and prolong survival time.
2. Analysis of the biomechanical property and histocompatibility of acellular porcine fascia
Qi SONG ; Kai ZHANG ; Juan TANG ; Kejie CAI ; Yonghua ZHAI ; Kunpeng PANG ; Xuejiao QIN
Chinese Journal of Plastic Surgery 2017;33(5):373-378
Objective:
To study the biomechanical property and histocompatibility of acellular porcine fascia so as to supply a new substitute material for tissue repair.
Methods:
Samples of normal porcine fascia, acellular porcine fascia and normal human fascia were prepared for histological and biomechanical examination. Xenogeneic fresh porcine fascia, acellular porcine fascia and allogeneic rabbit fascia were implanted into the back of rabbit. Tissues were taken for HE staining and histocompatibility test.
Results:
Histological examination showed that the cellular components which elicit immune rejections had been removed in the acellular porcine fasciam, with the complete extracellular matrix reserved. Arrangement of collagen fiber was loose in the acellular porcine fascia. The biomechanical performance test of the three samples showed that there was no significant difference in the extreme tensile strength (4.47±0.54) MPa, (4.49±0.91) MPa, (4.79±1.35) MPa for acellular porcine fascia, normal porcine fascia and normal human fascia respecively,