Objective To study the influence of aging and chemotherapeutic drugs of breast cancer patients on chemotherapy-induced amenorrhea (CIA) and to guide the further selection of drugs for chemotherapy.Methods We prospectively studied the CIA of the premenopausal breast cancer patients and compared the difference in CIA between the patients who were at different aging periods or received different chemotherapeutics. Results 137 patients were followed up.The occurrence rate of CIA and long-term chemotherapy-induced amenorrhea(LCIA)were 73.72%(101/137)and 43.80%(60/137)respectively.The rate of CIA and LCIA was significandy higher in older women(＞40 years)than young women(≤40 years,X2=25.32,18.42,P＜0.05).The recovery rate of CIA in young women was 61.90%(13/21)which was significantly higher than the older women[35.00%(28/80);X2=4.99,P=0.025].The difference in the rate of LCIA was statistically significant between the older women (＞40 years)who received different anthracyclinebased chemotherapy(X2=6.92,P=0.031).Conclusion Age is an important factor for the CIA.Chemotherapy has less influence on the menstruation of younger women(≤40) and most amenorrhea is reversible.For older women,the rate of LCIA is different in patients who receive imported epirubicin,domestic epirubicin or pirarubicin.

Forkhead Box m1 ( Foxm1) is a component of the Fox transcription factor family. It is only detected in proliferating cells, but disappears when cells enter into their terminal differentiation phase. Foxml is closely related to cellular growth mainly through inhibiting cyclin-dependent kinase(cdk) inhibitors to influence cell proliferation. It also participates in growth hormone mediated cell multiplication. The overexpression of Foxml has been observed in many tumor cell lines and malignant tumors, indicating that Foxml might be an essential proto-oncogene in carcinoaenesis. Upregulation of Foxml is sufficient to induce genomic instability due to loss of heterozygosity and variation of copy numbers. Foxml-induced genomic instability was significantly enhanced and accumulated with increasing cell passages. Foxml might become a new potential target for the treatment human cancer based on future investigations.

The research of spine related disease is an emerging interdisciplinary subject and the key point is the spinal biomechanical properties.In this paper,the method of studying biomechanical properties of lumhar and cervical vertebra based on 3D finite element model is analyzed.Three kinds of method in building finite element model are specified:geometric modeling method,3D coordinatngraphic modeling method and image modeling method.The three key steps of image modeling method for building of basic geometric model are extracted as defining material behavior of vertebra and soft tissue,defining boundary condition,and confirming of the model.Then two principal improving aspects of building finite element model and the foreground of the research are discussed.

The majority of women diagnosed with early-stage breast-cancer have an excellent long-term prognosis, but many still suffer from worsened life quality and infertility caused by chemotherapy-induced amenorrhea(CIA). The risk of CIA varies by patient age, but is not significantly influenced by chemotherapeutic regimens. CIA will improve disease-free survival and overall survival for patients with hormonal receptor positive tumors. For low-risk patients and patients with the intention of maintaining fertility, proper treatments need to be chosen to preserve their reproductive function.

Predictive factors of neoadjuvant chemotherapy play an important role in selecting sensitive chemotherapy regimen and avoiding unsuitable regimen for breast cancer patients. At present, estrogen receptor (ER), progestin receptor (PR) and HER-2 status are the main predictive factors. Other factors such as Ki-67 also seem to be promising for optimizing neoadjuvant chemotherapy.

Tooth extraction is a common operation in oral surgery. Traditional-extraction instruments, such as bone chisel, elevator, and bone hammer, lead to not only severe trauma but also unnecessary complications, and patients easily become nervous and apprehensive if tooth extraction is performed using these violent instruments. In recent years, with the develop- ment of minimally invasive concept and technology, various micro-power instruments have been used for tooth extraction. This innovative technology can reduce the iatrogenic trauma and complications of tooth extraction. Additionally, this technology can greatly decrease the patient's physical and mental pressure. The new equipment compensates for the deficiency of traditional tooth extraction equipment and facilitates the gradual replacement of the latter. Diverse micro-power systems have distinct strengths and weaknesses, so some auxiliary instruments are still needed during tooth extraction. This paper focuses on the various micro-power systems for tooth extraction and tries to compare the advantages and disadvantages of these systems. Selection and usage of auxiliary equipment are also introduced. Thus, this paper provides reference for the proper application of the micro-power systems in tooth extraction.
Humans ; Tooth Extraction ; instrumentation

More and more studies have indicated that the relationship between vitamin D pathway and asthma,and the mechanisms include multiple abnormal aspects of vitamin D pathway leading to abnormal em-bryonic development and immune system disorders and so on. This review summarizes the relationship between vitamin D,vitamin D binding protein,vitamin D receptors,related gene polymorphisms and the immune system to describe the pathogenesis of asthma.

Aim To apply sodium channels isolated and purified from rat brain and rat skelatal muscle sarcolemma to the study conotoxin.Methods Crude isolations of sodium channels were purified by 3 kinds of chromatography.The interaction between the sodium channels and conus betulinus was studied by the ligand binding experiment.Result The sequential chromatography resulted in 370-fold purification from rat brain and 2436-fold purification from rat skeletal muscle.Average specific binding active sites of purified sodium channels increased to 321 nmol?g-1 for rat brain and 268 nmol?g-1 for rat skeletal muscle respectively;Studying the interaction between venom from conus betulinus and the purified sodium channels indicated the fraction Ⅴ8 showed the highest affinity for the binding sites of the purified sodium channels.Conclusion Rat brain sodium channel and rat skeletal muscle sodium channel were purified to high purity;the fraction Ⅴ8 has the similar effect to that of the traditional ?-conotoxin.

Analysis on the cases demonstrated that the changes in their tongues possess some characteristics and changing regularity. As compared with the related ailments, indices of the proper and coating of the tongue presented very significant differeces. thus, the application of lingual picture in the diagnosis of perforation of the stomach and duodenum becomes feasible.

Purpose　To study the anti-inflammatory,anti-allergy and immunosuppressive effect of polyglycosides of tripterygium wilfordii Hook (TⅡ).　Methods　Animal model of acute and subacute inflammation,adjuvant arthritis,type Ⅳ and Ⅲ allergic reaction were used.Serum haemolysin level,lymphocyte proliferation and T-cell subsets in spleen were tested.　Results　TⅡ 60,120 mg/kg and pre(prednisone)10 mg/kg had marked inhibitory effect on carrageenine induced swelling,tampon induced granulation and on the prevention of adjuvant arthritis.The delayed type hypersensitivity reaction(type Ⅳ) and arthus reaction (type Ⅲ) was distinctly suppressed.It had a suppressive action on serum haemolysin and lymphocyte proliferation with and without concanavatin A which was dose dependent.In the T-cell subsets:TⅡ 60 mg/kg decreased TS and TⅡ 120 mg/kg inhibited both TS and TH,preacted mainly on TH and rendered the decreased ratio of TH/TS.　Conclusions　TⅡ has suppressive effect on inflammation,allergic reaction and immune function.