1.Development and application of blood donor role identity scale (BDRIS)
Yongen TAN ; Guiyun XIE ; Yanlin HE ; Ting ZHANG ; Lan WU ; Shijie LI ; Jinyan CHEN
Chinese Journal of Blood Transfusion 2022;35(8):869-872
【Objective】 To further determine the relationship between blood donor role cognition and blood donation behavior, then prepare of blood donor role identity scale(BDRIS). 【Methods】 The preparation of the scale was divided into five stages. It includes literature retrieval, expert interview, construction of the basic framework of the scale, scale test and statistical index test. The study focused on items selection, dimensions identification, measurement reliability, content and structural validity. 【Results】 The blood donor role identity scale consisted of 35 items. Exploratory factor analysis divided the items into six common factors, including role identity, role expectation, current situation of blood collection and supply, role conflict, external reward and blood donation experience. The α of scale was 0.840. 【Conclusion】 The reliability and validity of the scale meet the basic measurement requirements, and the framework of the blood donor role scale is basically formed. It can be used as one of the means to explore the ways and mechanisms of the role identity of blood donors in blood donation behavior.
2.A Rare Case of Lung Adenocarcinoma with EGFR L833V/H835L Co-mutation and Literature Review.
Yongen MIAO ; Yukun WANG ; Ping LI ; Min TAN ; Tingting WEN ; Changhui WANG ; Shuanshuan XIE
Chinese Journal of Lung Cancer 2023;26(10):795-800
Epidermal growth factor receptor (EGFR) mutations are the most common driver genes in the development of non-small cell lung cancer (NSCLC), of which mutations in exons 18-21 are frequent, especially the loss of exon 19 and exon 21 L858R mutation are the most frequent. Other rare gene mutations are rare. Simultaneous occurrence of two or more rare EGFR mutations are extremely rare in lung cancer, and the incidence of EGFR L833V/H835L rare gene compound mutations is very low, and there is little clinical data and evidence of relevant treatment methods. Some EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are effective in treating lung cancer patients with rare gene mutations. In this article, we reported a case of NSCLC patient with a rare gene compound mutation EGFR L833V/H835L, who responded to Afatinib in combination with Anilotinib treatment well after 5 months of treatment, and computed tomography (CT) showed shrinkage of lung lesions. Meanwhile, we also compiled previously reported NSCLC patients with EGFR L833V/H835L rare gene compound mutation and summarized the characteristics of this group of patients and the effect of applying different kinds of EGFR-TKIs treatment.
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Humans
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Adenocarcinoma of Lung/genetics*
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Carcinoma, Non-Small-Cell Lung/pathology*
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ErbB Receptors/genetics*
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Lung Neoplasms/pathology*
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Mutation
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Protein Kinase Inhibitors/therapeutic use*