BACKGROUND: Echinococcosis alveolaris were not easily discovered in prophasel Although used various kinds of imaging and immunity test, misdiagnosis rate of echinococcosis alveolaris was still high.OBJECTIVE: To study radioimmunoimaging of ~(131)Ⅰ-labelled anti-alveolar hydatid polyclonal antibody in the rat model with Echinococcus multilocularis in vivo.METHODS: Totally 36 Wistar rats were randomly divided into 3 groups. A group included 12 alveolar echinococcosis rats, B group included 12 normal rats, C group included 12 alveolar echinococcosis rats. Rats in the A and B group were injected intrapedtoneally 1 mL ~(131)Ⅰ-labelled anti-alveolar echinococcosis polyclonal antibodies (37 MBq), those in the C group were injected intraperitoneally I mL ~(131)Ⅰ-(37 MBq). All rats were imaged 24, 48, 72, 96 hours later with ECT to measure region of interest (ROI) of alveolar hydatid. The unit weight radioactive counts per minute of three group rats organs were measured after 96 hours, and the targetto-nontarget (TINT) ratios were calculated in A group rats.RESULTS AND CONCLUSION: In A group rat inoculated right lobe of liver alveolar echinococcosis, radioactive parts of the distribution could be seen. And ROI of alveolar echinococcosis were the highest at 72 hours. After dissection the locations were in line, and it was no significant radioactive liver distdbution in B and C group. Rats were sacrified after 96 hours, in vitro determination of radioactive counts show that A group echinococcus multilocularis was (18.610±3.401)x10~3 cpm/g, which was greater than organs except thyroid and gastric tissues (P ＜ 0.001). The rest of organize T/NT ratios were greater than 1.28 apart from the thyroid and gastric tissues. The difference of unit weight radioactive counts per minute of three group had no obviously significance except the polypide tissues (P ＞ 0.05). This proves that ~(131)Ⅰ-1abelled anti-alveolar echinococcosis polyclonal antibodY successfully combinated with alveolar echinococcosis.

Objective To analyze the changes of radioactivity of the marginal zone of hepatic alveolar echinococcosis (HAE) before and after the treatment with albendazole liposomes,and to explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in therapeutic response.Methods From July 2011 to July 2015,37 patients (21 males,16 females;average age (53±12) years) with HAE were selected and underwent 18F-FDG PET/CT imaging before routine medication with albendazole liposomes (10 mg · d-1 · kg-1),and the maximum standardized uptake value (SUVmax) of the margin of lesions was calculated.PET/CT imaging was performed again 6 months later to measure the SUVmax of the marginal lesions.Two-sample t test was used to analyze the data.Results In 37 patients with HAE,SUVmax before treatment was 4.88± 1.86,which was higher than that of 24 patients with reduced lesion size after treatment (3.63± 1.38;t =5.24,P＜ 0.001).Conclusion 18F-FDG PET/CT is useful for evaluating the radioactivity of marginal zone of HAE before and after the treatment with albendazole liposomes,and SUVmax of the marginal zone could be valuable for therapeutic response evaluation.

Objective:To evaluate the value of 18F-fluorodeoxyglucose positron emission computed tomography ( 18F-FDG PET/CT) myocardial metabolic image quality by the ratio of the maximum standard uptake value (M/B) of left ventricular myocardium to cardiac blood pool. Methods:The clinical data of 145 non diabetes patients with coronary heart disease who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2016 to August 2022 were retrospectively selected. All patients received intravenous injection of 18F-FDG for myocardial glucose metabolism imaging. According to the visual (qualitative) analysis, the image was divided into three categories: the best, the second best and the worst. Group A was the best image quality group, while Group B was the second best and the worst image quality group. The left ventricular myocardium, cardiac blood pool and descending aorta were semi-quantitatively analyzed, and M/B was calculated. Results:All 145 patients underwent image fusion analysis. Image visual (qualitative) analysis showed that the myocardial metabolic image quality of 111 patients was evaluated as the best (111 patients in Group A), 19 patients as the second best, and 15 patients as the worst (34 patients in Group B). The SUVmax value of the descending aorta in the two groups was lower than that of the left ventricle, with statistically significant difference (all P<0.05). The M/B value of group A was higher than that of group B, with statistically significant difference ( P<0.05). Conclusions:For the evaluation of image quality and the reliability of image interpretation, M/B value may be a good evaluation index, which reduces the interference of image quality evaluation due to high 18F-FDG uptake in some heart blood pools (background), and improves the accuracy of evaluation of myocardial viability.