Six N - acylsphingosines with molecular weight 509,537,565,607 and 621 respectively were isolated from the Chinese gorgonia Junceella squamata . The chain length of the carboxylic acid in them were C14,C16,C18,C20,C21 and C22,and the chain length of the bases were all C18. On the basis of their spectra and GCMS of the Chemical reaction products,their structure were elucidated.

Objective:To explore the relationship between coronary heart disease (CHD)and glucose metabolism dis-order.Methods:A total of 512 CHD patients received glucose tolerance test and coronary angiography,the percent-age of patients with impaired glucose tolerance (IGT)was counted,and degree of coronary disease was compared a-mong patients with different glucose tolerance.Results:Besides the 166 patients already diagnosed as diabetes melli-tus (DM),among the resting 346 patients undergoing oral glucose tolerance test (OGTT),there were 74 cases (21.39%)of new-onset DM and 152 cases (43.93%)of impaired glucose regulation (IGR).A total of 240 DM pa-tients occupied as high as 46.88% among the total 512 subjects.Compared with OGTT results,omission diagnose rate of DM was 43.2% and it′s 73.7% for IGR by single measuring fasting plasma glucose (FPG);compared with normal glucose tolerance (NGT)and IGT group,there were more of ≥ 3 vessel coronary disease (20.83% vs. 30.92% vs.58.75%)in DM group,P <0.05~ <0.01.Conclusion:Most CHD patients complicate with glucose metabolism disorder.Percentage of patients with≥ 3 vessel coronary disease is significant rise in DM group than those of NGT and IGT group.OGTT can significantly raise detection rate of glucose metabolism disorder.

This article analyzed the construction, experience and enlightenment of agriculture and forestry germplasm resources and TCM production and marketing bases based on current situation of construction of germplasm resources of Chinese medicinal herbs and market demand for high-quality Chinese medicinal herbs. It proposed that systems should be established first;plans should be improved;work division should be scientific;staple Chinese medicinal herbs demanded by the society should be set as focus;species should be set as basic units. Germplasm resource collection, quality identification and improved variety breeding should be carried out simultaneously, with a purpose to provide references for the construction and exploitation and utilization of TCM germplasm resources.

Objective To study the chemical constituents of starfish Asterias rollestoni Bell.Methods The constituents were isolated by chromatography methods and identified by spectroscopic and chemical analyses.Results and Conclusion A novel compound was obtained and identified as(2S,3S,4R)-2-(13'-methyl-pentadecanoylamino)-nondecane-1,3,4-triol.The compound was reported first time and named as rollceramide A.

Alcoholic (70%) extract of Pinellia ternate, Arisaeme yunnanense and Typhonium flagelliforme were analysed by UY-spectrometry. Results showed that each of them had its own characteristics spectrum and was repcatable. This provides a method for the identification of three kinds of drug.It was discovered that the wavelength of maximum absorbance showed aggreement,when P.ternata from different origin were analysed by UV-spectrometry.

Objective: To establish the quality control standards for Brains' King Oral solution. Methods: Rhizoma Gastrodia, Rhizoma et Radix Noto-pterygii in oral solution were identified by TLC. The content of gastrodin in Brain's King Oral Solution was determined by HPLC with external standard. The average recovery was 99.22% and RSD was 0.99%(n=6).Results: These methods are simple, accurate and specific.Conclusion: These methods can be used for the quality control of Brain's King Oral Solution.

Objective To explore the general characteristics of the psychological sub-health state and to analyze the factors pos-sibly leading to the psychological sub-health state in order to provide the scientific basis for the treatment and prevention of the psy-chological sub-health state .Methods The individuals with the physical examination in our hospital were performed the psychologi-cal heath survey .Among them ,1 712 cases of psychological sub-health were taken as the research group and contemporaneous 1 902 cases of normal health were taken as the control group .The Symptom Check List-90(SCL-90) was adopted to compare the two groups and the logistic regression analysis was adopted to analyze the risk factors possibly leading to the psychological sub-health occurrence .Results The average scores of 20 factors in SCL-90 in the research group were higher than those in the control group , the difference was statistically significant (P<0 .05) ,in which ,the scores of interpersonal relationship sensitivity (22 .1 ± 5 .7) ,para-noid(14 .1 ± 5 .2) and the others(17 .5 ± 6 .3) in the research group were significantly higher than the critical scores with obvious symptoms .The logistic regression analysis results showed that :the sleep quality(OR=1 .843) ,accidental injury(OR=2 .634) ,eco-nomical status(OR=3 .032 ,and professional type(OR=4 .684) were the independent risk factors of the psychological sub-health occurrence .Conclusion The local patients with psychological sub-health were more prominent in the more sensitivity of the inter-personal relationship ,paranoid and poor sleep ,especially the intellectuals ,individuals with poor sleep and the crowd with accidental injury are prone to develop psychological sub-health .

Co-citations of highly cited papers on gene annotation covered in Web of Science were analyzed by clustering analysis using clustering software after the word matrix of resource literature and highly cited papers was formed, which showed that the application of text mining on gene annotation includes use of authorized tools, development of text mining tools and algorithms, and verification of text mining tools.

Objective To stuty the metabolites of marine fungus Julella avicenniae from the South China Sea.Methods The fungus J.avicenniae was extracted with AcOEt,separated,and purified by column chromatographies on silica gel.All the compounds were identified on the basis of spectral analysis(IR,MS,NMR) and chemical evidence.Results One novel compound was identified from its extract of marine fungus J.avicenniae from the South China Sea.Conclusion One novel compound,avicenniaene,is isolated from the marine fungus J.avicenniae from the South China Sea.