Objective To explore the effects of providing quality nurse′s resources to the grassroots hospitals (county level) on psychological empowerment of nurses.Methods A total of 123 nurses from some county hospital were investigated by convenience sampling method from October 2014 to June 2016 using general data questionnaire and Psychological Empowerment Scale before and after the training of empowerment,and the Results were compared between before and after.Results Before training,in the control group and the experimental group,the total scores of psychological empowerment were (14.92±1.24) and (14.84±1.64)(t=0.107,P>0.05). After training, in the control group and the experimental group, the total scores of psychological empowerment were (14.74±1.31) and (16.44±1.68)(t= 2.312,P<0.05).Conclusions Providing quality nurse's resources to the grassroots hospitals (county level) can help to improve nurse′s psychological empowerment.

Malignant tumors are one of the main causes of death from chronic diseases in China,and their incidence and mortality rates show an in-creasing trend year by year.Advanced non-surgical treatment of malignant tumors is an important means of improving patients'prognosis and en-hancing their quality of life.The traditional Chinese medicine Ganoderma lucidum has anti-tumor ef-fects and plays a role in the treatment of many ma-lignant tumors.In this paper,a systematic review of the effects of Ganoderma lucidum active ingredi-ents on tumors has been conducted at home and abroad in the past five years to explore the anti-tu-mor mechanism of Ganoderma lucidum active in-gredients and to lay a theoretical foundation for the application of Ganoderma lucidum active ingre-dients in clinical practice.

Background::Hypothermia therapy has been suggested to attenuate myocardial necrosis; however, the clinical implementation as a valid therapeutic strategy has failed, and new approaches are needed to translate into clinical applications. This study aimed to assess the feasibility, safety, and efficacy of a novel selective intracoronary hypothermia (SICH) device in mitigating myocardial reperfusion injury.Methods::This study comprised two phases. The first phase of the SICH was performed in a normal porcine model for 30 minutes ( n = 5) to evaluate its feasibility. The second phase was conducted in a porcine myocardial infarction (MI) model of myocardial ischemia/reperfusion which was performed by balloon occlusion of the left anterior descending coronary artery for 60 minutes and maintained for 42 days. Pigs in the hypothermia group ( n = 8) received hypothermia intervention onset reperfusion for 30 minutes and controls ( n = 8) received no intervention. All animals were followed for 42 days. Cardiac magnetic resonance analysis (five and 42 days post-MI) and a series of biomarkers/histological studies were performed. Results::The average time to lower temperatures to a steady state was 4.8 ± 0.8 s. SICH had no impact on blood pressure or heart rate and was safely performed without complications by using a 3.9 F catheter. Interleukin-6 (IL-6), tumor necrosis factor-α, C-reactive protein (CRP), and brain natriuretic peptide (BNP) were lower at 60 min post perfusion in pigs that underwent SICH as compared with the control group. On day 5 post MI/R, edema, intramyocardial hemorrhage, and microvascular obstruction were reduced in the hypothermia group. On day 42 post MI/R, the infarct size, IL-6, CRP, BNP, and matrix metalloproteinase-9 were reduced, and the ejection fraction was improved in pigs that underwent SICH.Conclusions::The SICH device safely and effectively reduced the infarct size and improved heart function in a pig model of MI/R. These beneficial effects indicate the clinical potential of SICH for treatment of myocardial reperfusion injury.

Objective:In this study, we aimed to determine the change and clinical significance of serum level Apo A1 in MM patients.Methods:In total, 412 multiple myeloma patients were examined. SPSS 22.0 was used for data analysis. Correlation analysis was performed using linear correlation or Spearman rank correlation coefficients. Measurement data were analyzed with the t-test, Mann-Whitney U-test, or oneway analysis of variance (ANOVA) . Used the ROC curve to calculate the cutoff value and compared the OS and PFS between high Apo A1 subgroup and low Apo A1 subgroup with Kaplan-Meier survival analysis.Results:Our study showed that value of Apo A1 in the patient group was lower than that in the control group (0.89 g/L vs 1.24 g/L, P<0.05) . We found that Apo A1 dynamically changed with different MM stages. As it was increased when the disease was in remission, and decreased after disease in progression. According the result of multivariate analysis Apo A1 reduction become the independent risk factors of MM. On the basis of Kaplan-Meier survival analysis between high Apo A1 subgroup and low Apo A1 subgroup, we found higher Apo A1 patienta had longer OS rate and PFS. Conclusions:Apo A1 is a useful biomarker of tumor burden and a prognostic factor of multiple myeloma.

Objective:Retrospective analysis of the epidemiological and clinical characteristics of the novel coronavirus pneumonia (COVID-19) in children, to provide suggestions for the clinical diagnosis and treatment of children infected with SARS-CoV-2.Methods:7 COVID-19 children admitted to Xiangyang Central Hospital from January to February 2020 were studied. The epidemiological, clinical, laboratory, radiological characteristics and disease outcome data were obtained from data collection forms and electronic medical records.Results:Among the 7 children, 3 were male and 4 were female, median age was 8 years (2.6-14.0), 2 patients with co-morbidities , 4 patients with family aggregation history, two of them are brothers and sisters, all of the 7 children had a history of high-risk epidemiology. The main clinical symptoms of children with COVID-19 were fever (4 cases), cough and expectoration (5 cases), whereas others were asymptomatic (2 cases). The peripheral blood manifestations of the patients were as follows: abnormal leukocyte count was observed in 1 case, decrease of neutrophil was observed in 2 cases , 1 case with increase of C-reactive protein (CRP) and 3 cases with increase of lactate dehydrogenase, other indexes like the lymphocyte count was normal in all patients. There were no significant changes in serum albumin, AST, CK and SCR in children. Most of the chest CT findings of children were high density lesions of lung lobes, 2 of them had typical ground glass density shadow. The clinical types of 5 children were common type and the rest are subclinical type. All cases were cured by antiviral plus symptomatic treatment(Arbidol), and combination of traditional Chinese medicine prescription treatment.Conclusion:Children COVID-19 were mainly mild and common cases, most of them were familial clusters, the laboratory examination showed no specificity and their prognosis was well.

Objective To investigate the value of CT value in differential diagnosis of benign and malignant thyroid calcification.Methods The CT plain scan data of 48 cases of thyroid benign calcification and 26 cases of thyroid malignant calcification confirmed by pathology were analyzed retrospectively,and the CT values of 74 cases of thyroid calcification were measured.The best threshold and the maximum area under the receiver operator characteristic(ROC)curve for differentiating benign and malignant thyroid calcification were determined by plotting ROC curve,and the corresponding specificity,sensitivity,positive predictive value,negative predictive value,false positive rate,false negative rate,accuracy and Jordan index were calculated.Then the optimal threshold value was used as a parameter for differential diagnosis of benign and malignant thyroid calcification,and we adoptted χ2 analyze the statistical difference between benign and malignant thyroid calcification in CT gray value.Results The area under the ROC curve was 0.814,and the 95%confidence interval(CI)was 0.712-0.915.When the CT value was 869.5HU(for the convenience of 870HU),the specificity was 69.2%,the sensitivity was 81.3%,the positive predictive value was 64.3%,the negative predictive value was 82.6%,the false positive rate was 20.8%,and the false negative rate was 30.8%,the accuracy was 75.7%and the maximum of the Youden index was 0.505.When 870HU was taken as the differential diagnosis parameter of thyroid benign and malignant calcification(χ2=16.795,P<0.001).Conclusion When the CT value is 870HU,it has important value in differential diagnosis of benign and malignant thyroid calcification.