OBJECTIVE: Through 3.0 T MRI study the ear and sinus lesions of patients with acute carbon monoxide poisoning. METHOD: From 2012 to 2015 collected the MRI images of the 45 patients with acute carbon monoxide poisoning, observe their changes of middle ear and mastoid and sinus imaging. RESULT: The middle ear injury of mastoid 41 cases (91.1%), 22 cases (48.9%) of maxillary sinus injury, ethmoid sinus injury in 20 cases (44.4%), sphenoid sinus 9 cases (20.0%), 5 cases (11.1%) of frontal sinus injury. Carbon monoxide poisoning patients according to clinical symptoms can be divided into light, medium and heavy 3 groups, observing the ear sinus damage degree for comparison between groups, found to have significant differences (P < 0.05). CONCLUSION The patients with acute carbon monoxide poisoning ear and sinus injury should cause the attention of the medical staff, MRI can reflect people's ears from the details and the damage degree of the sinuses.
Carbon Monoxide Poisoning ; diagnosis ; Ear, Middle ; pathology ; Ethmoid Sinus ; pathology ; Frontal Sinus ; pathology ; Humans ; Magnetic Resonance Imaging ; Maxillary Sinus ; pathology ; Paranasal Sinuses ; pathology ; Sphenoid Sinus ; pathology

Abscess ; microbiology ; therapy ; Cellulitis ; Humans ; Nasal Septum ; microbiology

We present an analysis method of electrocardiogram (ECG) to determine patients' ventricular late potentials (VLPs) characteristics by means of wavelet packet transform and entropy (ApEn). The results indicate that the patients with VLPs tend to have higher ApEn values than do those without. So ApEn can be used as an indicator and a BP neural network for distinguishing between the two patient groups. The experiment result shows that this method has higher distinguishability.
Electrocardiography ; methods ; Entropy ; Heart Ventricles ; physiopathology ; Humans ; Neural Networks (Computer) ; Signal Processing, Computer-Assisted ; Ventricular Function

OBJECTIVE: To analyze the principle mechanism of the arcus plantaris and its clinical application. METHODS: The states of forces sustained by the arcus plantaris were analyzed and calculated according to the mechanism of the quadratic parabolic arch. RESULTS: The aponeurosis plantaris corresponded to the pull rod of the arcus plantaris. The medial and lateral longitudinal arches formed by the pedal bones were stable with the rod, but unstable without the rod. In the latter condition, on loading, the force sustained by the parabolic arch became a force sustained by a simple beam, and the arcus plantaris tended to disappear and to be flattened. Clinically, 240 feet with talipes equinus were treated with triple arthrodesis. In 34 out of the reexamined 156 feet, the aponeurosis plantaris was cut in addition to the triple arthrodesis and was immobilized with cast for 3 months. One or two years later, their arcus plantaris disappeared, pain developed when walking, and some of them walked with the midtarsal joint against the ground. Then, the triple arthrodesis and shortening of the aponeurosis plantaris were applied on 18 cases, and osteotomy of the calcaneus and reconstruction of the aponeurosis plantaris were made on 10 cases and satisfactory effects were obtained. CONCLUSIONS: In order to achieve satisfactory therapeutic effects of the triple arthrodesis, we should reestablish the arcus plantaris and accurately treat the aponeurosis plantaris for the balance of the surrounding muscle force.

Objective To explore the effect of exercise training,hypoxic exposure,and different hy-poxic trainings on the mitophagy and angiogenesis in skeletal muscles of mice.Methods C57BL/6J male mice were randomly divided into a control(C),hypoxic exposure(H),exercise training(E),live high training low(LHTL),and live low training high(LLTH)groups,each of 8.Group H and E were exposed to hypoxia(14.8%～12.5%O2 concentration)for 8 h and normoxic exercise in treadmill per day respectively,while group LHTL undertook the both and group LLTH exercised ever day in the hy-poxic room for 6 weeks(5 days/week).Skeletal muscle samples were harvested after intervention and then frozen or histologically fixed.Western blotting was used to assess gastrocnemius protein,and im-munohistochemistry was employed to evaluate quadriceps angiogenesis.Moreover,the gastrocnemius mi-tochondria were observed using the transmission electron microscope(TEM).Results Compared with group C,the autophagy maker microtubule-associated protein light chain 3Ⅱ/Ⅰ protein ratio(LC3Ⅱ/LC3Ⅰ)of group LHTL and unc51-like autophagy-activating kinase 1 phosphorylation(p-Ulk1)of group E and LHTL increased significantly increased significantly(P<0.01 and P<0.05).Compared with group C,Parkin protein of group LHTL and LLTH,and PTEN induced putative kinase 1(Pink1)pro-tein levels of group H,LHTL and LLTH increased significantly(P<0.05).Moreover,BCL2/adenovirus E1B19Kda protein-interacting protein 3L(Nix)protein levels in group E,LHTL and LLTH increased significantly(P<0.05).In addition,Pink1 protein and LC3Ⅱ/LC3Ⅰ levels of group LHTL were high-er than group E(P<0.05).Compared with group C,the skeletal muscle vascular endothelial growth fac-tor(VEGF)levels of group H,E,LHTL and LLTH and cluster of differentiation 31(CD31)level of group LHTL and LLTH also increased significantly(P<0.05).TEM found the mitochondrial volume ex-pansion in group E and LHTL,and the non-injured myofibril in all groups.Conclusion Hypoxic train-ing,especially LHTL,upregulating mitophagy and angiogenesis in skeletal muscles,is superior to exer-cise training or hypoxic exposure in promoting mitophagy.

OBJECTIVE： To systematically evaluate the efficacy and safety of cyclosporin combined with glucocorticoid versus cyclophosphamide combined with glucocorticoid in the treatment of membranous nephropathy （MN）. METHODS： Retrieved from Embase， Medline， CNKI， VIP and Wanfang database， RCTs about cyclosporin combined with glucocorticoid （trial group） versus cyclophosphamide combined with glucocorticoid （control group） in the treatment of MN were collected. Meta-analysis was conducted by using Rev Man 5.3 statistical software after literature screening， data extraction and quality evaluation with Jadad scale. RESULTS： Totally 6 RCTs were included， involving 312 patients in total. Results of Meta-analysis showed that remission rate 3 months after treatment [OR＝3.42，95％CI（2.05，5.71），P＜0.000 01] and relapse rate [OR＝3.12，95％CI（1.45，6.70），P＝0.004]， leukocyte count 12 months after treatment [MD＝1.77，95％CI（0.96，2.58），P＜0.000 1] in trial group were significantly higher than control group. There was no statistical significance in remission rate 6 months after treatment [OR＝2.06，95％CI（0.80，5.30），P＝0.13] and remission rate 12 months after treatment [OR＝1.30，95％CI（0.68，2.48），P＝0.42]， blood creatinine level 3 months after treatment [MD＝－1.55，95％CI（－6.72，3.62），P＝0.56] and blood creatinine level 6 months after treatment [MD＝－1.21，95％CI（－5.96，3.54），P＝0.62]， cholesterol level 12 months after treatment [MD＝－0.77，   95％CI（－1.81，0.28），P＝0.15] or ALT level[MD＝－0.40，95％CI（－4.38，3.58），P＝0.98] between 2 groups. ADR were reported in 5 RCTs， but their results were different. CONCLUSIONS： Long-term efficacy of cyclosporine combined with corticosteroid is similar to that of cyclophosphamide combined with corticosteroid in the treatment of MN. Cyclosporin combined with glucocorticoid has a faster effect， but a higher relapse rate.