This report described the cell ultrastructure in six cases of non-granulocytic leukaemia (two cases each for acute lymphocytic, and acute monocytic leukaemia, and two for multiple myeloma) .According to their ultrastructural characteristics, the differential diagnosis of the three leukaemic cell types and the nature of their dense granules and cytoplasmic fibrils under the electron microscopy have been discussed.

Peripheral blood cells of ten cases of acute lymphocytic leukemia (ALL) were detected by zymochemical method (myeloperoxidase MPO, platelet peroxidase PPO) and cytochemical method with CD serial monoclonal antibody (CD5, CD7, CD9, CD16, CD13, CD19, CD20, CD33, CD41, CD42) labelled by immunogold. The concrete procedure of serial electron microscopy for ALL diagnosis is also described.

Bone marrow cells from 2 patients with panmyelosis leukemia were observed with transmission electron microscopy (TEM),scanning electron microscopy (SEM),myeloperoxidase (MPO) and platelet peroxidase (PPO).A lot of immature cells were found in the granulocytic, monocytic,erythrocytic and megakaryocytic series.Their major morphologic characteristics were as follows. In the erythrocytic series, petaloid-like and ball-like structure appeared and their perinuclear cisters were wider. In the myelomonocytic series, nuclear-cytoplasmic organelle asynchrony could be seen makedly and the nucleus appeared fully mature, but the cytoplasm contained only a few organelles, and in some cells the organells were often locally distributed. In the megakaryocytic series, many micromegakaryocytes were seen. In this paper, the ultrastructura] changes of four kinds of cells and their relationship with erythro-leukemia are also discussed.