Aim The chronic toxicity of tea polyphenols(TP) in dogs was observed. Methods 18 dogs were randomly divided into high, middle and low dose TP groups and one control group . When TP was given(po) by 650 mg?kg-1?d-1,65 mg?kg-1?d-1,6.5 mg?kg-1?d-1 respectively for 90 d and after TP was stopped for two weeks, the general conditions, ECG, blood routine, urine routine, serum lipids, blood sugar, coagulation time, and hepatic and kidney function were detected respectively. Results These mdices were not different from each other among the 4 groups before, during and after administration of TP . The level of serum total cholesterol was progressively decreased in TP groups. Conclusion TP has no toxic effect on dogs and can decrease the level of serum total cholesterol in normal dogs.

Aim To evaluate the protective effect of anti_digoxin antiserum on hypoxic injury myocardium and its mechanism. Methods It was observed that different concentration anti_digoxin antiserum effect on endogenous digitalis_like factor and cell membrane ATPase activity in hypoxic myocardium model. Results The level of endogenous digitalis_like factor was remarkably higher, cell membrane ATPase activity were remarkably lower in hypoxic group than those of normal group; anti_digoxin antiserum can resume membrane ATPase activity.Conclusion Rise of endogenous digitalis_like factor was basic of molecular biology of myocardial damage during myocardial hypoxia. Anti_digoxin antiserum has lightened myocardial injury and has protective effect on hypoxic myocardium by against effect of endogenous digitalis_like factor.