High-dose melphalan (Mel) is considered as a current standard preparative regimen in autologous stem cell transplantation (ASCT) for multiple myeloma (MM). Irradiation in total body (TBI) combined with Mel is not superior to Mel alone, and the adverse reactions are increased at the same time. The efficacy of 200 mg/m2 Mel is much better than that of 100-140 mg/m2 Mel in young patients. Several regimens including MelBU, TBC, BCV, MET, MTC, MelBCNU, VMel, MTC as well as bendamustine have similar treatment outcomes compared with 200 mg/m2 Mel. Other strategies need to be evaluated in different trials.

Objective To observe the effect of levocamitine on cardiac function of patients with dilated cardiomyopathy (DCM).Methods 40 patients with DCM were randomly divided into control group (n =20) and the experimental group(20 cases).Control group was given conventional drug such as digitalis,furosemide,benazepril hydrochloride,antisterone for treatment,the experimental group was given levocarnitine on the basis of control group.The treatment efficacy and the situation of cardiac function were compared between the two groups.Results The total effective rate was 95.0％ and 80.0％ in the experimental group and the control group,respectively,the difference was statistically significant(x2 =10.286,P ＜ 0.01).Compared with the control group,the parameters of stroke volume,cardiac output,ejection fraction,and left ventricular fractional shortening rate were significantly increased in the experimental group after treatment(all P ＜ 0.05).Conclusion Levocarnitine can improve cardiac function based on the conventional treatment.

Serum prostate-specific antigen (PSA) is composed of the PSA precursor protein (proPSA) in the absence of the leader peptide induced by human kallikrein 2 (hK2). There are many forms of PSA in the blood, including free PSA and bound PSA. Serum proPSA, as a free PSA, has many isoforms, among which, [-2]proPSA (p2PSA) cannot be activated by hK2 and therefore exists stably in the blood. Serum p2PSA is a homologous isomer of PSA. Serum prostate health index and % p2PSA, as the derivative indexes of p2PSA and molecular markers associated with the development and progression of prostate cancer, can reduce serum PSA test-induced excessive diagnosis and treatment of the malignancy and improve the accuracy of its prediction. This review summarizes recent progress in the studies of serum p2PSA and its derivative indexes in prostate cancer.
Humans ; Male ; Prostate-Specific Antigen ; blood ; Prostatic Neoplasms ; blood ; immunology ; Protein Isoforms ; blood

Metabolic markers were released in the process of bone resorption and formation during bone remodelling. These markers have been extensively studied in trials of osteoporosis and other metabolic bone disorders during the past de?cades. Bone metabolic markers can replenish bone mineral density in the management of osteoporosis, but their use in clini?cal practice is challenged by their variability. Recently, there are many great progress in research of bone metabolic markers application in non metabolic bone disorders.

Non-small cell lung cancer has a poor prognosis. Many patients who were proved to have none lymph node metastasis still relapse after operation. It may be caused by micrometastases which can′t be detected by conventional pathologic technique. Recently immunocytochemistry and moleculer methods are used to detect micrometastases in the peripheral blood, bone marrow or lymph node near the tumor. But the standard and reliable methods need to be developed and the clinical significance of micrometastases need to be discussed.

Objective: To assess the feasibility and accuracy of real-time three dimensional echocardiography (RT-3DE) in quantitative evaluation of left ventricular (LV) volume and ejection fraction (EF) in patients with ventricular aneurysm and myocardial infarction. Methods: Twenty-three p atients with left ventricular aneurysm combined with myocardial infarction were examined by RT-3DE, two dimensional echocardiography Simpson's method, and M-mode Teichholz method separately. The following parameters: left ventricular end diastolic volume (LVEDV), end systolic volume (ESV), stroke volume (SV) and EF were obtained by each method and the results were compared with those obtained by left ventriculography (LVG). Results: The values of LVEDV, LVESV, SV, and EF determined by RT-3DE showed good correlations with those determined by LVG (r=0.92, 0.90, 0.88, and 0.91, respectively; P<0.001), with the values by RT-3DE slightly smaller than those by LVG(P>0.05). The values of LVEDV, LVESV, SV, and EF determined by Simpson's method also showed good correlations with those determined by LVG (r=0.85, 0.87, 0.86, 0.91, respectively; P<0.001), with the values by Simpson's method smaller than those by LVG (P<0.05 for LVEDV and LVESV). The values of LVEDV, LVESV, SV, and EF determined by M-mode Teichholz method also showed good correlations with those determined by LVG (r=0.73, 0.71, 0.70, 0.65, respectively; P<0.05), with the values by M-mode Teichholz method larger than those by LVG(P<0.05 or P<0.01). Conclusion: RT-3DE is a more accurate for evalua tion of LV volume and EF in patients with aneurysm combined with myocardial infarction.

Objective:To evaluate the effect of percutaneous coronary intervention (PCI) on mitral regurgitation (MR) in patients with acute myocardial infarction (AMI). Methods: A total of 213 AMI patients were divided int o PCI group (n = 87, PCI + medication) and medication group(n= 126, medication) according to the treatments they received. Echocardiographic examination was conducted in patients during admission and 6 months follow-up. Color Doppler was used to determine the degree of MR. Echocardiogram indices included MR degree, left ventricular end-diastolic diameter (LVEDd) ,left ventricular end-systolic diameter (LVEDs) ,left ventricular end-diastolic volume (LVEDV) ,left ventricular end-systolic volume(LVESV) ,and left ventricular ejection fraction (LVEF). Results: The overall incidence of MR was 28. 6% in 213 patients during admission. The MR incidence in patients with acute inferior myocardial infarction was higher than that in patients with other parts of infarction (34. 5% vs 22. 3% PO. 05), while the incidence in medication group increased significantly than that during admission(43. 7% vs 30. 2%,P

Objective To observe the effects of different doses of Yinxingdamo injection on changes of nerve-specific enolase (NSE) of patients with medium-sized brain injury and discusse the mechanism of Yinxingdamo injection in the treatment of brain injury. Methods The contents of serum NSE in 33 cases of craniocerebral injury were dectected by ELISA test and the results were analyzed. Results NSE levels in patients with brain injury were significantly higher than normal people (p ＜0.05). Yinxingdamo injection can reduce the content of NSE for brain injury patients. This reduction related with the dosage of the medicine, showing the higher the dosage is used, the greater reduction may be.Conclusion Yinxingdamo injection can reduce NSE in serum of patients with brain injury, and this may be the mechanism of Yinxingdamo injection in treating craniocerebral injury.

Objective:To probe into the influences of psychosocial risk factors and family psyche environment on smoking behavior of adolescents.Methods:Psychosocial risk factors and family psyche environment of 806 adolescents with smoking behavior and that of 3603 controls were investigated with Family Environment Scale, Symptom Checklist 90 and Behavior Questionnaire.Results:Rebelliousness, Risk Taking, Early Maturity, Problem Helplessness of adolescents were related to smoking. The scores of cohesion, expressiveness, achievement orientation and intellectual-culture orientation in Family Environment Scale of the smoking group were lower than those of controls (P

A harmonious physician-patient relationship is closely correlated with hospital culture construction.This paper explores the correlation from the perspectives of roles in building up decent fame of hospitals,promoting the construction of medical ethics,cultivating a fine humanistic medical atmosphere,strengthening the social responsibility of hospitals,and further clarifies the important function of hospital culture construction in constructing a harmonious physician-patient relationship.