6.Apply association rules to analysis adverse drug reactions of shuxuening injection based on spontaneous reporting system data.
Wei YANG ; Yan-Ming XIE ; Yong-Yang XIANG
China Journal of Chinese Materia Medica 2014;39(18):3616-3620
This research based on the analysis of spontaneous reporting system (SRS) data which the 9 601 case reports of Shuxuening injection adverse drug reactions (ADR) in national adverse drug reaction monitoring center during 2005-2012. Apply to the association rules to analysis of the relationship between Shuxuening injection's ADR and the characteristics of ADR reports were. We found that ADR commonly combination were "nausea + breath + chills + vomiting", "nausea + chills + vomiting + palpitations", and their confidence level were 100%. The ADR and the case reports information commonly combination were "itching, and glucose and sodium chloride Injection, and generally ADR report, and normal dosage", "palpitation, and glucose and sodium chloride injection, and normal dosage, and new report", "chills, and generally ADR report, and normal dosage, and 0.9% sodium chloride injection", and their confidence level were 100% too. The results showed that patients using Shuxuening injection occurred most of ADRs were systemic damage, skin and its accessories damage, digestive system damage, etc. And most of cases were generally and new reports, and patients with normal dosage. The ADR's occurred had little related with solvent. It is showed that the Shuxuening injection occurred of ADR mainly related to drug composition. So Shuxuening injection used in clinical need to closely observation, and focus on the ADR reaction, and to do a good job of drug risk management.
Adverse Drug Reaction Reporting Systems
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Drug-Related Side Effects and Adverse Reactions
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diagnosis
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Drugs, Chinese Herbal
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adverse effects
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Female
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Humans
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Male
7.Application of proteomic techniques in pediatric research.
Wei-qin ZHOU ; Xiang-yong KONG ; Zhi-chun FENG
Chinese Journal of Pediatrics 2011;49(7):526-530
Child
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Humans
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Proteomics
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methods
10.Formation of Magnetosomes in Magnetotactic Bacteria
Wei LIN ; Lan-Xiang TIAN ; Yong-Xin PAN ;
Microbiology 1992;0(03):-
Magnetotactic bacteria can orient and migrate along ambient geomagnetic field lines because of their intracellular magnetic particles ( referred as magnetosomes) , which comprise nanometer-sized, membrane-bound crystals of the magnetic iron minerals. Magnetosome formation is a mineralization process with very strict biological controls over the accumulation, transportation and nucleation in the cell. This paper describes the current progresses of magnetosome formation and the function of proteins involved in this biomineralization process.