Objective To observe the effect of levocamitine on cardiac function of patients with dilated cardiomyopathy (DCM).Methods 40 patients with DCM were randomly divided into control group (n =20) and the experimental group(20 cases).Control group was given conventional drug such as digitalis,furosemide,benazepril hydrochloride,antisterone for treatment,the experimental group was given levocarnitine on the basis of control group.The treatment efficacy and the situation of cardiac function were compared between the two groups.Results The total effective rate was 95.0％ and 80.0％ in the experimental group and the control group,respectively,the difference was statistically significant(x2 =10.286,P ＜ 0.01).Compared with the control group,the parameters of stroke volume,cardiac output,ejection fraction,and left ventricular fractional shortening rate were significantly increased in the experimental group after treatment(all P ＜ 0.05).Conclusion Levocarnitine can improve cardiac function based on the conventional treatment.

High-dose melphalan (Mel) is considered as a current standard preparative regimen in autologous stem cell transplantation (ASCT) for multiple myeloma (MM). Irradiation in total body (TBI) combined with Mel is not superior to Mel alone, and the adverse reactions are increased at the same time. The efficacy of 200 mg/m2 Mel is much better than that of 100-140 mg/m2 Mel in young patients. Several regimens including MelBU, TBC, BCV, MET, MTC, MelBCNU, VMel, MTC as well as bendamustine have similar treatment outcomes compared with 200 mg/m2 Mel. Other strategies need to be evaluated in different trials.

Metabolic markers were released in the process of bone resorption and formation during bone remodelling. These markers have been extensively studied in trials of osteoporosis and other metabolic bone disorders during the past de?cades. Bone metabolic markers can replenish bone mineral density in the management of osteoporosis, but their use in clini?cal practice is challenged by their variability. Recently, there are many great progress in research of bone metabolic markers application in non metabolic bone disorders.

Objective To investigate the prognostic significance of preoperative fibrinogen levels and explore a new prognostic predictor for colon cancer patients. Methods From January 2007 to Decem-ber 2008,the clinical data of colon cancer patients with radical were reviewed retrospectively. Patients were divided into different groups according to BMI,tumor size,stage,differentiation degree,gross type,vascular infiltration,CEA and mGPS score. Differences in preoperative fibrinogen concentration and overall survival were compared between groups. Results A total of 255 patients were enrolled in this study,the mean pre-operative fibrinogen concentration of enrolled patients was(3. 17 ± 0. 88)g/ L. There were significant differ-ences in And preoperative fibrinogen concentration among patients with different tumor size,stage,differen-tiation degree,gross type,vascular infiltration,CEA and mGPS(P < 0. 05). Moreover,result of univariate analysis manifested that the level of preoperative fibrinogen concentration was associated with the overall survival rate. Conclusion Preoperative fibrinogen concentration is associated with the clinicopathologic features of patients with colon cancer,which can serve as a new prognostic marker for prognosis evaluation.

ObjectiveTo report a series of female patients with bladder cancer who underwent gynecologic-tract sparing radical cystectomy with long term follow-up.MethodsFifty-five female patients between the ages of 25 and 82 years who underwent gynecologic-tract sparing radical cystectomy between 1990 and 2010 were reviewed retrospectively.Pathologic characteristics and survival ( overall and cancerspecific) were reported.Survival was estimated using Kaplan-Meier methods,and Cox proportional hazards regression analyses were performed to determine factors associated with mortality.ResultsFive patients were lost in follow up.Fifty-five women with a mean follow-up of 55.2 months were analyzed.The 3,5 and 10-year cancer specific survival (CSS) was 65％,61％ and 61％,respectively,and the corresponding overall survival (OS) was 61％,54％ and 42％,respectively.For patients with organ confined disease ( ≤ pT2N0M0) the 5-year CSS and OS was 84％ and 72％,while for those with non organ confined disease ( ≥pT3N0M0) the 5-year CSS and OS reduced to 29％ and 29％.Pathologic lymph node status (HR =3.877,P =0.019) and pathologic staging ( HR =3.992,P =0.011 ) were the only clinical or pathologic characteristics significantly associated with survival.ConclusionsFor patients with pathologically organ-confined bladder cancer ( ≤ pT2 N0 M0 ),gynecologic-tract sparing radical cystectomy is an oncologically safe treatment modality,while for those with ≥ pT3N0M0 or positive pelvic lymph nodes,gynecologic-traet sparing radical cystectomy may need large scale randomized control trials to justify its validity,pathological stage and lymph node status are the most important key points when choosing appropriate patients.

Objective To compare the effect and safety of venlafaxine sustained-release tablet combined with Shuganjieyu capsule and venlafaxine sustained-release tablet used singlely in the treatment of moderate to severe poststroke depression.Methods 70 patients suffered from moderate to severe post-stroke depression were randomly divided into two groups,35 cases in each group.The patients in the control group were only treated with venlafaxine sustained-release tablet,and the patients in the study group were treated by venlafaxine sustained-release tablet combined with Shuganjieyu capsule.The treatment lasted 6 weeks.The therapeutic effect and safety were evaluated by the positive and negative syndrome scale of HAMD (17 items),and treatment emergent symptom scale of TESS.Results After treatment for 6 weeks,the total effective rate of the study group was 88.57％,which was significantly higher than 65.71％ of the control group (x2 =5.19,P ＜ 0.05).The HAM D score of the study group w.as (16.42 ± 6.07) points,and the HAMD score of the control group was(10.54 ± 5.23) points after 6 weeks.The difference was statistically significant between the two groups (t =4.34,P ＜ 0.01).The difference of TESS score between two groups was not significant(t =0.18,P ＞ 0.05).Conclusion Venlafaxine sustained-release tablet combined with Shuganjieyu capsule is effective and safe in the treatment of moderate to severe post-stroke depression.

On sjogrens' syndrome (SS) clinical treatment,most of the clinician focused on nourishing Yim to moisten dryness.In fact,Yang qi was the metabolic power of the human body fluid,exerting an important role in the incidence and prognosis of SS.For SS of Yang deficiency syndrome,water,Qi and fire can not be guided back to the kidney was the key cause,therefore,warming kidney Yang should be the therapeutic principle.Modified Yimhuo decoction can be used in its treatment.

Objective To explore the impact of placenta polypeptide injection on fracture healing time and the incidence of infec-tion in patients with limb fractures .Methods 138 cases with limb fractures admitted to our hospital from February 2010 to Febru-ary 2012 were randomly divided into two groups ,and each group had 69 patients .The control group was given conventional treat-ment while the observation group was given placenta polypeptide injection on the basis of the conventional treatment .The bone healing time and infection rates were observed .Results The limbs fracture healing time of observation group was significantly shorter than that of control group (P<0 .05) .The infection rate of observation group (1 .45% ) was significantly lower than that of control group (10 .14% ,P<0 .05) .Conclusion The placenta polypeptide injection for treatment of limb fractures can effectively decrease fracture healing time ,and significantly reduce the rate of infection .

In recent years , along with the continuous accumulation of clinical experiences and the improvement of surgical devices, the percutaneous coronary intervention (PCI) has become a perfect treatment method and been widely used in the clinic . Hence , the coronary heart disease ( CHD ) patients have received better treat-ment results. However, the in-stent restenosis is still a big problem after PCI. The combination of Chinese and modern medicine in the prevention of restenosis has become a focused hotspot . In order to further under-stand this issue , this article discussed the Chinese and modern medicine mechanism in order to provide more thoughts for clinical practice .

Isoflavones as a kind of phytoestrogen exist in soy plant widely. With the advantages of estrogen, they can regulate endocrine function of the human body, reduce blood cholesterol, decrease the incidence of coronary heart disease, prevent osteoporosis, inhibit tumor growth, and relieve pain. This article summarized the investigations on the medical value of isoflavones in recent years.