Objective To study the expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia (CIN) and cervical cancer and their clinical significance. Methods Immunohistochemistry (S-P method) was used to detect the expressions of MCM5 and Ki67 in 50 CIN and 49 cervical cancer. Results The positive expression rate of MCM5 and Ki67 in normal cervical epithelium, CIN Ⅰ-Ⅱ, CIN Ⅲ and cervical cancer were 26.7%, 72.0%, 80.0%, 97.9% and 10.0%, 32.4%, 84.0%, 97.9% respectively. The positive expression rate of MCM5 was significantly different between CIN and cervical cancer (P

Acupuncture Therapy ; Diarrhea ; therapy ; Female ; Humans ; Young Adult

The aim of this study is to examine the influence of risk factors which include modifiable and non-modifiable risk factors on the likelihood of newly diagnosed hypertension among Malaysians. A cross-sectional population-based survey: The Fourth National Health and Morbidity Survey (2011) was conducted by the Ministry of Health, Malaysia in 2011. The sample included 20,095 participants. This study uses binomial logistic regression techniques to predict the likelihood of modifiable and non-modifiable risk factors of newly diagnosed hypertension among the individuals. The analysis has been carried out by estimating odds ratio with 95% confidence interval. This study reveals that obese and overweight respondents as well as current drinkers have increased chances of having newly diagnosed hypertension. In contrast to that, only physically inactive respondents exhibit lower odds of newly diagnosed hypertension. Besides that, the significant predictors, which include older respondents, retirees and home makers, as well as lower educated respondents are respectively found to be more likely to have newly diagnosed hypertension. On the other hand, female respondents, urban dwellers, including the Chinese and Indian respondents, the highest income earners and underweight respondents have been found to have statistically significant lower odds of newly diagnosed hypertension. Through the insightful findings and evidence, this research provides a platform for the early detection and prevention of newly diagnosed hypertension. Hence, this study offers a means to monitor and control the increasing prevalence of newly diagnosed hypertension in Malaysia.
Newly diagnosed hypertension ; prevention ; modifiable risk factors ; non-modifiable risk factors

Objective To evaluate the early therapeutic effect of flail chest with pulmonary contusion by using different mode of mechanical ventilation. Methods Twenty-nine patients of flail chest with pulmonary contusion were analysed retrospectively. All the patients were treated with the ventilator Bear1000. Two groups were established: invasion group was treated with SIMV+PEEP(8 cases) and CPAP+PSV (7 cases), noninvasion group was treated with NIPPV(14 cases). Results There was no death in all the patients. CPAP+PSV was more effective than SIMV+PEEP not only in decreasing breath rate and improving hypoxemia but also in decreasing peak inspiratory pressure(P

Glucocorticoids ; therapeutic use ; Humans ; Olfaction Disorders ; drug therapy ; Treatment Outcome

miRNA is a kind of endogenous non-coding short RNA. Mature miRNA was formed through the process of shearing and transporting after genetic transcription. miRNA exhibits many important biological functions through regulating expression and translation of target mRNAs. Different miRNAs may act as oncogenes or antioncogenes, and have tissue specificity. The progress of the tumorigenesis is usually accompanied by expression-profile changes of miRNAs. MiRNA regulates many tumor biological behaviors such as differentiation, proliferation, apoptosis, invasion, metastasis, and drug resistance of tumors. Furthermore, some miRNAs have clinical significance in predicting prognosis of tumor patients.

Along with the development of interventional appliances and proficiency of operational skills,the interventional diagnosis and treatment via hepatic portal vein system have achieved great progress and improvement.However,in order to further exploit the advantages of interventional diagnosis and treatment, the review of the anatomical structures,normal aberrance of portal venous system were needed.Getting familiar with pathologic condition to discover the new interventional appliances and embolic agents,and then in term of conduct the research on a very tough substancial base in a down-to-earth manner were important.

Objective To research the possible relati onship between exercise-induced HSP72mRNA and ultrastructure of myocardium in rats. Methods 36 SD rats were randomly divided into four groups:control group,one week training group(T1),two weeks training group(T2),three weeks train ing group(T3).The rats in T1,T2 and T3 were trained on treadmill with 75%VO 2ma x intensity for 1 week,2 weeks and 3 weeks respectively.All rats were sacrificed within 24 hours after training and HSP72 mRNA expression of cardiac myocytes we re detected by reverse transcription-polymerase chain reaction(RT-PCR).The chang es of ultrastructure of myocardium in rats were also analyzed by electron micros cope.Results (1)HSP72 mRNA expression in T1 and T2 group were si gnificant higher than controls and T3 group.(2)According to electron microscope results of cardiac myocyte in rats,the sequence of damage degree from slight to severe was T3

0.05). With prolonged of the training period, all the above indexes reverted gradually. Conclusion There might exist an inner correlation between the protective function of myocardium and the expression of myocardial HSP72 mRNA after training.

Objective To summarize the effect and safety of percutaneous coronary intervention (PCI) for CHD in patients with single patent coronary artery. Methods We collected the data of CHD in 10 patients with single patent coronary artery who underwent PCI and analyzed them retrospectively. Results All patients with single patent coronary artery had successful PCI. Symptoms of all the CHD patients had been significantly relieved after PCI. No major adverse cadiac events occurred in hospitalization. Conclusion The data suggest that the patients with single patent coronary artery might be treated with PCI effectively and safely.