Objective To study the expressions of MCM5 and Ki67 in cervical intraepithelial neoplasia (CIN) and cervical cancer and their clinical significance. Methods Immunohistochemistry (S-P method) was used to detect the expressions of MCM5 and Ki67 in 50 CIN and 49 cervical cancer. Results The positive expression rate of MCM5 and Ki67 in normal cervical epithelium, CIN Ⅰ-Ⅱ, CIN Ⅲ and cervical cancer were 26.7%, 72.0%, 80.0%, 97.9% and 10.0%, 32.4%, 84.0%, 97.9% respectively. The positive expression rate of MCM5 was significantly different between CIN and cervical cancer (P

Acupuncture Therapy ; Diarrhea ; therapy ; Female ; Humans ; Young Adult

The aim of this study is to examine the influence of risk factors which include modifiable and non-modifiable risk factors on the likelihood of newly diagnosed hypertension among Malaysians. A cross-sectional population-based survey: The Fourth National Health and Morbidity Survey (2011) was conducted by the Ministry of Health, Malaysia in 2011. The sample included 20,095 participants. This study uses binomial logistic regression techniques to predict the likelihood of modifiable and non-modifiable risk factors of newly diagnosed hypertension among the individuals. The analysis has been carried out by estimating odds ratio with 95% confidence interval. This study reveals that obese and overweight respondents as well as current drinkers have increased chances of having newly diagnosed hypertension. In contrast to that, only physically inactive respondents exhibit lower odds of newly diagnosed hypertension. Besides that, the significant predictors, which include older respondents, retirees and home makers, as well as lower educated respondents are respectively found to be more likely to have newly diagnosed hypertension. On the other hand, female respondents, urban dwellers, including the Chinese and Indian respondents, the highest income earners and underweight respondents have been found to have statistically significant lower odds of newly diagnosed hypertension. Through the insightful findings and evidence, this research provides a platform for the early detection and prevention of newly diagnosed hypertension. Hence, this study offers a means to monitor and control the increasing prevalence of newly diagnosed hypertension in Malaysia.
Newly diagnosed hypertension ; prevention ; modifiable risk factors ; non-modifiable risk factors

Objective To evaluate the early therapeutic effect of flail chest with pulmonary contusion by using different mode of mechanical ventilation. Methods Twenty-nine patients of flail chest with pulmonary contusion were analysed retrospectively. All the patients were treated with the ventilator Bear1000. Two groups were established: invasion group was treated with SIMV+PEEP(8 cases) and CPAP+PSV (7 cases), noninvasion group was treated with NIPPV(14 cases). Results There was no death in all the patients. CPAP+PSV was more effective than SIMV+PEEP not only in decreasing breath rate and improving hypoxemia but also in decreasing peak inspiratory pressure(P

Glucocorticoids ; therapeutic use ; Humans ; Olfaction Disorders ; drug therapy ; Treatment Outcome

Along with the development of interventional appliances and proficiency of operational skills,the interventional diagnosis and treatment via hepatic portal vein system have achieved great progress and improvement.However,in order to further exploit the advantages of interventional diagnosis and treatment, the review of the anatomical structures,normal aberrance of portal venous system were needed.Getting familiar with pathologic condition to discover the new interventional appliances and embolic agents,and then in term of conduct the research on a very tough substancial base in a down-to-earth manner were important.

Objective To research the possible relati onship between exercise-induced HSP72mRNA and ultrastructure of myocardium in rats. Methods 36 SD rats were randomly divided into four groups:control group,one week training group(T1),two weeks training group(T2),three weeks train ing group(T3).The rats in T1,T2 and T3 were trained on treadmill with 75%VO 2ma x intensity for 1 week,2 weeks and 3 weeks respectively.All rats were sacrificed within 24 hours after training and HSP72 mRNA expression of cardiac myocytes we re detected by reverse transcription-polymerase chain reaction(RT-PCR).The chang es of ultrastructure of myocardium in rats were also analyzed by electron micros cope.Results (1)HSP72 mRNA expression in T1 and T2 group were si gnificant higher than controls and T3 group.(2)According to electron microscope results of cardiac myocyte in rats,the sequence of damage degree from slight to severe was T3

0.05). With prolonged of the training period, all the above indexes reverted gradually. Conclusion There might exist an inner correlation between the protective function of myocardium and the expression of myocardial HSP72 mRNA after training.

The effects of cyanide poisoning on the contractibility of the cardiac muscle were observed after the dogs were infused intravenously with a lethal dose of NaCN (2.5 mg/kg) within 2 minutes through a cannulated femoral vein. Heart rate (HR) , left ventricular pressure (LVP) , the largest changing rate of LVP (LVP?dp/dtmax), cardiac muscle contractibility (CMC) , the largest changing rate of CMC (CMC?dc/dtmax) , and ECG changes were recorded. It was found that there was an initial excitatory response of cardiac functions in the first minute of NaCN infusion, and then a drastic cardiac failure occurred, which resulted in the rapid death of the dogs within 10 minutes after NaCN administration. The changes of myocardial contractibility were slower than those of .other cardiac parameters, which implies that cyanide can exert an excitation on the myocardium initially. Our results indicate that the effects of cyanide on myocardial contractibility may be one of the important factors to induce serious arrhythmia,which in turn results fatal cardiac failure.

Objective To verify whether the modified open-door laminoplasty with C3 laminectomy is effectve in preventing postoperative axial symptom. Methods Since March 2001 to March 2005, 44 patients who underwent modified open-door laminoplasty with semispinalis cervicis insertion intact were included in this study(group A). 50 patients who underwent conventional open-door laminoplasty in the authors' department during the same period were served as control(group B). Preoperative and postoperative Japanese Orthopedic Association(JOA) scores, the degree of axial symptom, ranges of neck motion, cervical curvature index were recorded and compared. Results The average JOA recovery rate was 59.2%?11.3% for group A and 60.1%?19.5% for group B. There was no significant difference in JOA recovery rate between two groups. The rate of patients with evident axial symptoms was 22.7% in group A and 54.0% in group B, and the difference was statistically significant(P