Pancreatic hyperplastic nodules were experimentally produced in male Sprague-Dawley rats by single doses of intravenous injection of 4-hydroxyaminoquinoline-1-oxide(4-HAQO), 5 mg, 10 mg, 20 mg and 30 mg per 1kg of body weight. Every ten rats were sacrificed after 1 day, 1 week and monthly until 6 months. Within the first week, pancreatic acini and islets were severely affected with necrosis and the adjacent acinar cells underwent vacuolization. But, pancreatic ductules remained relatively unaffected. The degrees of acinar cell degeneration were proportionally increased as with the increased doses of 4-HAQO administration. The levels of blood glucose and serum amylase were closely corresponding to the light microscopic features of the pancreas. Two months after administration of 4-HAQO, the nongranular acinar cells started to proliferate and their proportion of total acinar cells was 35%, whereas that of control group was 15%, after 3 months the proportion of nongranular cells was decreased. After 6 months, multiple hyperplastic nodules were discovered within the pancreatic acini of all 12 rats, and the largest one measured 500 micro in diameter. Each hyperplastic nodule was uniformly composed of larger cells in two folds of normal cells with hyperchromatic muclei and prominent nucleoli together with a few zymogen granules in their cytoplasms. Ultrastructurally, the cells contained abundant dilated endoplasmic reticulum and markedly decreased zymogen granules. Nuclear heterochromatin became finely dispersed with loss of marginal clumping. During the regeneration process, admixture of islet cells with membrance-bounded granules was identified among the clusters of regenerating acinar cells. On the basis of above findings, the induction of hyperplastic nodules in rat pancreas by 4-HAQO was confirmed, and its histogenesis may reflect a nodular hyperplasia of non-granular acinar cells with potential progress as a neoplastic lesion. And the evidence of the hypothesis that the pancreatic exocrine cells and endocrine cells are in same origin, was presented.
Male ; Humans ; Rats ; Animals

Since its introduction, fluorescein angiography has been widely used in diagnosing and evaluating treatment of diseases of the retina, uveal tract, and optic nerve. A case with Behcet's disease was studied by means of fluorescein fundus angiography. This, pre summed a retinal angiopathy, has been diagnosed Behcet's disease after developing symptoms of hypopyon iritis, intermittent fever, aphthous stomatitis, and genital ulceration. The fluorescein angiography in Behcet's disease is typically shown a specific finding. Extravasation of the dye waS most conspicuous in capillaries over-lying the optic nerve head, the radial peripapillary capillaries, retinal capillaries proper and retinal veins. Retinal arteriols generally lacked extravasation phenomenon. Edematous swelling of the disc, diffuse turbidity of the posterior fundus and macular cysts are regarded as consquences of the fluorographically confirmed increased permeability of the retinal vessels with resultant edema of the neuropithelium. Pathogenesis of the retinal angiopathy in Behcet's disease and diseases with retinal edema and hyperpermeability were discussed with references. The fluorographic findings thus indicate that the pathological involvement of retinal vessels play a major factor in the diagnosis and prognosis of ocular manifestation of Behcet's disease.
Angiography* ; Capillaries ; Diagnosis ; Edema ; Fever ; Fluorescein Angiography ; Fluorescein* ; Iritis ; Optic Disk ; Optic Nerve ; Papilledema ; Permeability ; Prognosis ; Retina ; Retinal Vein ; Retinal Vessels ; Retinaldehyde ; Stomatitis, Aphthous ; Ulcer

No abstract available.
Bile*

The authors analysed 196 cases of convulsive disorder in children who were admitted to the pediatric department of Kyunghee Hospital from June 1993. Blood samples were drawn immediately following seizures on arrival. Serum prolactin values were measured by radioimmunoassay. The results obtained were as follows: 1) Mean serum prolactin value was 55.4+/-20.8ng/ml in generalized seizures within 1 hr following seizures, 22.5+/-3.9ng/ml in partial seizures. There was a significant difference between generalized scizures and partial scizures (p<0.05). 2) Mean serum prolactin value was 23.5+/-9.7ng/ml in generalized seizures within 1~3 hrs following seizures, 10.4+/-4.9ng/ml in partial seizures. There was a significant difference between generalized seizures and partial seizures (p<0.05). 3) Mean serum prolactin value was 9.5+/-4.4ng/ml in generalized seizures 3 hrs following seizures, 9.8+/-4.8ng/ml in partial seizures. There was no significant difference between generalized seizures and partial seizures (p>0.05). We found transient hyperprolactinemia following generalized seizures but a little change following gartial seizures. Postictal elevation of serum prolactin may represent a biochemical marker of generalized and partial seizures.
Biomarkers ; Child ; Humans ; Hyperprolactinemia ; Prolactin* ; Radioimmunoassay ; Seizures

No abstract available.
Cicatrix* ; Contracture* ; Forearm* ; Hand*

The use of the interlocking intramedullary nails expand the possibilities for treatment of femoral shaft fractures, as illustrated by consistent and satisfactory clinical results. However, the technique is relatively complex compared to conventional nails and frequently poses technical problems. A retrospective review was undertaken of twenty-eight patients with femoral shaft fractures which had technical problems after undergoing the closed reduction and internal fixation with interlocking intramedullary nail procedure. We studied the types of the problems. Their causes, the frequency of problems with various kinds of nails, and discussed solutions of the problems. There were 21 additional comminutions and intraop erative splinterings, 8 angular deformities, 3 malpositioned nails, 3 loosened distal locked screws, 2 brocken drill bits, and 1 femoral neck fracture. Bone-union was attained in all cases (28 patients), but the period of treatment to attain bone-union was protracted to an average of 6.8 (5-12) months. In 3 cases, the knee joint range of motion was of limited flexion, 70 to 90 degrees, but in all other cases full range of motion was realized. 7 cases required 2 or more operations. The hospitalization period was for an average of 3.6 months. In conclusion, the importance of careful preoperative planning and experienced surgical technique cannot be overemphasized because we could see no significant difference in the occurence of technical problems in several kinds of the nail.
Congenital Abnormalities ; Femoral Neck Fractures ; Fracture Fixation, Intramedullary ; Hospitalization ; Humans ; Knee Joint ; Range of Motion, Articular ; Retrospective Studies

Isolated avulsion fracture of the tibial attachment of the posterior cruciate ligament has been thought very rare. We also had experienced only nine cases of above injury in our center during 5.5 years from January, 1976 to June, 1981. Eight cases of them were followed for an average of the thirteen months, but one of them was eliminated from the study because follow-up study was impossible for the case. The purposes of this paper are to present eight cases of isolated avulsion fracture of the tibial attachment of the posterior cruciate ligament and to discuss the causes and mechanisms of the injury and the method of screw fixation for the avulsed fracture fragment. Seven were injured by traffic accident and one by fall on the knee. All cases seemed to be injured by the force directed against the flexed knee which violently stroke the anterior surface of the proximal end of the tibia or inferior portion of the knee and drove it backwards. We found the tear of posterior capsule only in one patient who was seeming injured by extensive force. All cases were treated operatively by means of screw fixation, and excellent results were obtained in five cases, good in two, and fair in one case.
Accidents, Traffic ; Follow-Up Studies ; Humans ; Knee ; Methods ; Posterior Cruciate Ligament ; Stroke ; Tears ; Tibia

Localized subconjunctival abscess, episcleritis, recurrent lid abscess, and chorioretinitis are not uncommon diseases of the eye due to various causes such as infective emboli, buried cilia, trauma, autoimmune reactions, or specific infection. The cysticercus cellu]osae has been found in all parts of the eye and the lid, but there are less common presentation of the infection foci than of the cysticercus cellulosae alone. A subconjunctival abscess which is located in the upper fornix of the right eye near the caruncle, episcleritis which is localized in the upper half of the conjunctiva of the left eye, a recurrent abscess of the lid which is located in the right lower lid, a chorioretinitis which is not good visualization because of many cells and flares in the vitreous body, are reported due to a cysticercus larva. No systemic manifestation of cysticercus is found at all. The literature for ocular cysticercosis is referred.
Abscess ; Chorioretinitis ; Cilia ; Conjunctiva ; Cysticercosis ; Cysticercus* ; Inflammation* ; Larva* ; Scleritis ; Vitreous Body

No abstract available.
Knee Injuries* ; Knee*

Approximately two thirds of stroke survivors have residual neurological deficits that persistently impair function. Hence, alternative strategies are needed to reduce the long-term disability and functional impairment from severe weakness of limbs. Generalization of treatment effect takes place when the effects of the therapy spread to a variety of related behaviors and similar movements. And the transfer effect that training of the limbs on one side of the body appeared to be shared by those on the other side simultaneously. The two concepts are closely linked together. These forms of learning are organized through a higher-level cerebral mechanism and can be associated corpus callosum. Several promising new rehabilitation approaches such as bilateral training are based on the transfer effect. The purpose of this review is to introduce transfer effect of treatment on motor learning after stroke.
Corpus Callosum ; Extremities ; Generalization (Psychology) ; Humans ; Hypogonadism ; Learning ; Mitochondrial Diseases ; Ophthalmoplegia ; Stroke ; Survivors