1.Boomerang Effects from Medical Practice and Prospective for Future Designing of Medical Education.
Journal of the Korean Medical Association 2002;45(3):245-248
No abstract available.
Education, Medical*
;
Prospective Studies*
2.Preparation of Physicians for the 21st Century in Korea.
Journal of the Korean Medical Association 2000;43(1):35-44
No abstract available.
Korea*
3.Physicians for the Twenty First Century: Building a Bridge to the Future Education Planning.
Korean Journal of Medical Education 1999;11(1):7-15
No abstract available.
Education*
5.Integrated Curriculum: A Pedagogical Background in Medical School.
Korean Journal of Medical Education 1998;10(1):1-10
No Abstract available.
Curriculum*
;
Schools, Medical*
6.Liver Cell Dysplasia: Analysis of 141 cases with reference to histopathologic Characterization and proliferative activity.
Korean Journal of Pathology 1992;26(4):338-347
Liver cell dysplasia of Anthony(LCD) is a common association in hepatocellular carcinoma(HCC)-bearing liver and has been regarded as a premalignant condition with strong linkage to hepatitis B virus infection and cirrhosis. A total of 189 surgically resected livers [HCC(168 cases), cholangiocarcinoma(3 cases), metastatic carcinoma(3 cases), and non-neoplastic lesions(15 cases)] were reviewed to elucidate the nature of LCD by means of light microscopic examination, in situ hybridization method for HBV DNA and expression of proliferatin cell nuclear antigen(PCNA) using immunohistochemical technique. LCD was present in 141 cases(74.6%), and its prevalence rate was independently significant in HCCs with or without cirrhosis than other groups. There was no difference in mean age, although LCD-positive group was younger than its negative counterpart. Association rate of LCD in HCC-cirrhosis group was statistically significant than the non-cirrhotic group, and higher histological grading of LCD was correlated well with wider distribution pattern and clustering. Seropositivity of HBsAg was not correlated with presence of LCD or with histological grading. In situ hybridization techique using HBV DNA probe demonstrated fine granular stainable particles even in LCD cells. Immunohistochemical study for PCNA revealed that the proliferative activity of LCD was lower than that of the cirrhotic cell. With the above results it is concluded that LCD reflects neither a regenerating condition nor a premalignant lesion but suggest a reactive change.
Carcinoma, Hepatocellular
;
Neoplasm Metastasis
7.Obstructive Colitis: A Clinicopathologic Analysis of 7 Cases.
Korean Journal of Pathology 1996;30(12):1116-1122
Obstructive colitis is an ulceroinflammatory lesion of the large intestine at a distance proximal to the obstructing or potentially obstructing lesion of any etiology. It has been suggested that a rise in the intraluminal pressure related to the obstruction results in a fall in the intramural blood flow with subsequent ischemic necrosis. We examined 7 cases of surgically resected obstructive colitis associated with distal constrictive adenocarcinoma of the large intestine. Two cases of the obstructive colitis were radiologically suspected prior to surgery either as a separate tumor mass or diverticulosis, and another case was suggested to be a tumor seeding by colonoscopy. Grossly, five cases presented with single or multiple, shallow, well-demarcated ulcerative lesions, and the remaining two were featured with a segmental ulcerative lesion the with pseudopolypoid area. The ulceroinflammatory lesions were separated from the distal obstructive carcinoma by a skipped zone of relatively normal mucosa measuring 4-43 cm. The proximal colon to the obstructive lesions were obviously dilated except in one case. Microscopically, mucosa and submucosa were replaced by granulation tissue, and showed inflammatory cell infiltration and fibrin exudates. Muscle coat often accompanied ischemic contraction. Fissuring was noted in one case. The recognition of these lesions prior to or during surgery is stressed based on the morphological features corresponding to an ischemic change in the proximal mucosa to the primary obstructive lesion.
Adenocarcinoma
8.Multiple Localized Hyperplastic Gastropathy: Report of A Case with A Special Reference to its Growth Pattern.
Korean Journal of Pathology 1989;23(1):154-159
We present a case of localized mucosal hyperplasia of the stomach. The resected stomach contained four large, short stalked polyps, three of which were located in the anterior wall of body and the other in the posterior wall. In addition, numerous small sessile polyps were also scattered in the anterior and posterior fundic walls. Microscopically, the abnormally thick mucosa, carrying with it the muscularis mucosae and a thin core of loose fibrous tissue comprised the polyps by intraluminal infolding of widening of mucosal area. Abundant vasculature of the rugal pattern was prominent in the submucosa. The above findings suggest that the histogenesis of the polyps is related to both hyperplastic thickening and widening of mucosal areas in rugal pattern in the background of inverted distribution pattern of intestinal metaplasia.
9.Effect of sialadenectomy or administration of epidermal growth factor on initiation of hepatoma in rat.
Journal of the Korean Cancer Association 1993;25(2):196-201
No abstract available.
Animals
;
Carcinoma, Hepatocellular*
;
Epidermal Growth Factor*
;
Rats*
10.Diagnostic Accuracy in Endoscopic Gastric Biopsy - Part 1. Analysis of preoperative gastric biopsies in 236 cases with neoplastic lesions based on gastretomy and histotopographic investigation.
Korean Journal of Gastrointestinal Endoscopy 1983;3(1):10-16
Two hundreds and forty six preoperative endoseopic gastric biopsies from 236 conaecutive cases were subjected to the retrospective analyais of diagnostic accuracy among 597 tumor- bearing gastrectomy specimens confirmed by extended histotopographic investigations during a period of 1980 to 1981 at Seoul National University Hospital. The overall diagnostic accuracy of endoscopic gastric biopsy was 93.1% with 0.8% false positivity and 3.5% of false negative caaes; of those, the concordance rate of preoperative biopsy diagnosis based on the histotopographic investigation of the gastrectomy remained in 85.5%, whereas 75% of diagnostic discrepancy wae reaulted from inappropriate biopsy sampling or failure of neoplastic tissue obtainability; and the rest of 25% was mostly false negative cases. (continue...)
Biopsy*
;
Diagnosis
;
Gastrectomy
;
Retrospective Studies
;
Seoul