1.The Evaluation of Curative Effect and Safety Posteolateral Cervical Disc Herniation Discectomy Via Posterior Approach
Journal of Medical Research 2006;0(12):-
Objective To investigate the indication,safety and the validity of intervertebral discectomy via posterior approach.Methods There were 8 cases in our group.All received posterolateral intervertebral discectomy and nerve root decompression via posterior approach.The average follow-up period was 5.2 years.The improvement on pain and neurological signs were evaluated.Results Pain disappeared completely in 5 patients and significantly alleviated in the other 3.As to muscle strength and tendon jerk,we observed significant improvement in 6 patients and improvement in the other 2 patients.7 patients got back to their original work and 1 patient shifted to an easy job.No patient had complication.Conclusions Nucleus pulposus removal via posterior approach was a secure and effective one for posterolateral cervical intervertebral disc herniation.
2.Effect of Rho kinase inhibitor combined with hyperbaric oxygen on the recovery of neurological function after spinal cord injury in patients with thoracolumbar fractures
Chinese Journal of Biochemical Pharmaceutics 2015;35(10):85-87
Objective To observe effect of Rho kinase inhibitor combined with hyperbaric oxygen on the recovery of neurological function after spinal cord injury in patients with thoracolumbar fractures.Methods A total of 80 cases of thoracolumbar fractures combined with spinal cord injury patients as the research object, the packet by the standards of admission of single and double serial number, odd numbers were divided into control group, even number were divided into treatment group (40 cases in each group); two groups underwent surgical treatment, control group was given single usage fasudil treatment, treatment group was given hyperbaric oxygen therapy for auxiliary therapy on the basis of control group, Continuous treatment for two months.Compared neurological function scoring, grading, blood superoxide dismutase (SOD) , epithelial growth factor (EGF) , lipid peroxide (LPO) and adverse reactions pre-and post-treatment between two groups of patients.Results After treatment,total effective rate of treatment group (92.50%), ASIA sensory, movement scores were significantly higher than control group (75.00%)(P<0.05);Content of SOD and EGF of treatment group were significantly higher than control group(P<0.05);the adverse reaction rate (12.50%) was significantly lower than that of control group (32.50%)(P<0.05).Conclusion Rho kinase inhibitor combined with hyperbaric oxygen can significantly improve the degree of injury, neurological function and blood SOD, EGF, LPO content in patients with lumbar vertebral fractures combined with spinal cord injury, and the adverse reactions are few, has definite clinical effect.
3.Monitor selection of imaging diagnostic workstation configuration for PACS
Yong CHENG ; Gang WANG ; Weiguo CHEN
Chinese Medical Equipment Journal 2003;0(11):-
With growing dependence on picture archiving and communication systems(PACS) for viewing images,a quality assurance program to the condition of workstation displays and image quality guidelines for better cost-efficacy and diagnostic accuracy has become increasingly important.This article analyses and synthesizes the quality control of the PACS phantom workstation mainly from such aspects as the monitor resolution and brightness,the environment degree of illumination,statistics assessment method(ROC curve) and so on.
4.Effects of neoadjuvant chemotherapy on the hepatic function and histology of liver in patients with hepatic metastasis of colorectal cancer
Yong JI ; Gang HU ; Zuojun ZHEN ; Huanwei CHEN
Chinese Journal of Digestive Surgery 2013;12(11):879-881
Objective To investigate the effects of neoadjuvant chemotherapy on the hepatic function and histology of liver in patients with hepatic metastasis of colorectal cancer.Methods The clinical data of 65 patients with hepatic metastasis of colorectal cancer who received hepatectomy at the First People's Hospital of Foshan from January 2010 to September 2012 were retrospectively analyzed.Thirty-nine patients were in the experimental group,and they received partial hepatectomy 1 month after receiving a 6-month continous FOLFOX7 chemotherapy (5-fluorouracil + calcium leucovorin + oxaloplatin) ; 39 patients were in the control group,and they received partial hepatectomy without adjuvant chemotherapy.The perioperative condition,pre-and postoperative hepatic function,postoperative complications and the histopathological changes of the hepatic tissues of the 2 groups were compared by t test or chi-square test,data repeated measured were analyzed using the repeated measure analysis of variance.Results The operation time of the experimental group and the control group were (195 ± 37)minutes and (190 ±41) minutes,respectively,with no significant difference (t =0.1,P>0.05).The operative blood loss of the experimental group was (410 ± 75)ml,which was significantly greater than (348 ± 44) ml of the control group (t =6.3,P < 0.05).The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) at postoperative day 3 were (328 ± 121)U/L and (330 ± 120)U/L in the experimental group,which were significantly higher than (160 ±22) U/L and (168 ±26) U/L of the control group (t =13.4,12.8,P < 0.05).There were no significant differences in the levels of prothrombin time,AST,ALT,total bilirubin and albumin between the experimental group and the control group (t =1.0,0.0,1.4,1.3,0.4,P > 0.05).The levels of AST and ALT at postoperative day 7 were (243 ± 132) U/L and (253 ± 147)U/L in the experimental group,which were significantly higher than (90 ± 17)U/L and (99 ± 16)U/L of the control group (t=12.5,12.0,P<0.05).The incidence of congestion and edema of the liver was 71.8% (28/39) in the experimental group,which was significantly higher than 0 (0/26) of the control group (x2 =90.0,P < 0.05).The incidence of hepatic sinusoid expansion with liver cellular altrophy and necrosis was 48.7% (19/39),which was significantly higher than 15.4% (4/26) of the control group (x2=89.2,P < 0.05).Conclusion There is no effect of long-time FOLFOX7 chemotherapy on the hepatic function of the patients with hepatic metastasis of colorectal cancer who received hepatectomy 1 month later,but the postoperative hepatic function is affected.The hepatic parenchyma is changed after adjuvant chemotherapy,which might have adverse effect on hepatectomy.
5.The Reliability and Item Quality of Ten Medical Academic-courses From Two Angles
Yong ZENG ; Xueshan FENG ; Gang CHEN ; Yingqing LU
Chinese Journal of Medical Education Research 2003;0(04):-
Underlying both the angles of norm-referenced test and criterion-referenced test, the qualitative or(and)quantitative analysis and evaluation were made on the tests of 10 medical academic courses in recent 4 years in reliabil-ity and item quality. From the angle of norm-referenced test, 67.4 percent of the items had good quality, 60 percent ofthe tests could differentiate the classes and 12.5 percent of the papers could differentiate the individual person accord-ing to their reliability. However, from the angle of criterion-referenced test, approximately 90 percent of the items werequalified; 87.5% had high reliability to determine whether an examinee passes the test or not.[
7.Comparison of naveibine and cisplatin versus gemcitabine and cisplatin in refractory metastatic breast cancer
Zhong-Fu SHAO ; Gang XU ; Ming ZHOU ; Yong-Dong CHEN ;
Cancer Research and Clinic 1999;0(05):-
0.05).The degreeⅢ~Ⅳthrombocytopenia was more common in group A than in group B,but the degreeⅢ~Ⅳhypolekocytosis and phlebitis was more serious in group B.Conclusion NC and GC for treating refractory metastatic breast cancer have a high response rate and tolerable side effects.
8.The phenomenon of insulin resistance in cardiomyocytes during post-simulated ischemic reperfusion
Yong-Gang LI ; Huan-Wen CHEN ; Er-Yong ZHANG ; Donghu SUI ; Yingkang SHI ;
Chinese Journal of Thoracic and Cardiovascular Surgery 1995;0(05):-
0.05,vs control).Insulin stimulated glucose transport into cardiomyocytes in a dose-dependent fashion.Glucose uptake stimulated by insulin into cardiomyocytes was both decreased significantly in 15 mins reperfusian group and in 60 mins reperfusion group (P
9.Comparison of total laparoscopic vs open liver resection for tumors in segments Ⅶ and Ⅷ
Yong QIANG ; Zhen CHEN ; Wei WANG ; Dongzhi WANG ; Gang WANG ; Feiran WANG ; Zhong CHEN
Chinese Journal of General Surgery 2015;30(11):851-854
Objective To compare the clinical effect of total laparoscopic and open liver resection for tumors in segments Ⅶ and Ⅷ.Methods The clinical data of patients with tumors in segments Ⅶ and Ⅷ of the liver who met the inclusion criteria and received operation at Affiliated Hospital of Nantong University from January 2011 to January 2015 were retrospectively analyzed.Among these patients, there were 17 cases who received total laparoscopic liver resection (LLR group), and 25 cases who received open liver resection (OLR group).Results LLR group has obvious advantages in aspects of the level of serum alanine transaminase (ALT) on 1st and 3rd day postoperation, the time anal exsufflation, the drainage volume of abdominal cavity in 3 days after operation and the postoperative hospital stay than those in OLR group (respectively t =-3.075,-3.175,-2.499,-2.088,-2.419, all P < 0.05).There were no significant differences in blood transfusion rate, the resection margin to the tumor, the postoperative morbidity and the total medical cost between the two groups (x2 =1.437, t =-1.244, x2 =0.209, t =1.079, all P > 0.05).Though the mean operative time and intraoperative blood loss of LLR group compared with OLR group increased obviously (respectively t =3.360, 2.189, all P < 0.05).During the postoperative follow-up, there were no significant differences in the postoperative recurrence rate and the long-term survival rate in patients with malignant tumors (respectively x2 =0.240, 0.000, all P > 0.05).Conclusion The therapeutic effect of total laparoscopic and open liver resection are equal in segments Ⅷ and Ⅷ hepatectomy, while, LLR has advantages of less trauma.
10.Tumor suppressor gene ING1 differentially regulates HepG2 cell growth in an isoform-dependent manner.
Zhi ZHU ; Yong-mei LI ; Zhi-gang LUO ; Ying CHEN ; Ming-hua ZHU
Chinese Journal of Pathology 2009;38(9):623-625
Alternative Splicing
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Apoptosis
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Cell Cycle
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Cell Proliferation
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Cyclin-Dependent Kinase Inhibitor p21
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metabolism
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Hep G2 Cells
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Humans
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Inhibitor of Growth Protein 1
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Intracellular Signaling Peptides and Proteins
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genetics
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metabolism
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physiology
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Nuclear Proteins
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genetics
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metabolism
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physiology
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Plasmids
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Protein Isoforms
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Proto-Oncogene Proteins c-bcl-2
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metabolism
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Recombinant Proteins
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genetics
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metabolism
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Transfection
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Tumor Suppressor Protein p53
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metabolism
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Tumor Suppressor Proteins
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genetics
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metabolism
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physiology
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bcl-2-Associated X Protein
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metabolism