Objective:To explore if the therapeutic effect can be enhanced, the dose of levodopa-like medications can be decreased and the complications can be reduced by acupuncture treatment in the patients with Parkinson's disease (PD) who took levodopa-like medications for a long time. Methods: thirty cases of the patients, most of whom were noticed with the decreased therapeutic effect and drug-induced complications, were treated by puncturing Shuigou (GV 26) and Baihui (GV 20), by reduction of Madopa dose, and the patients' conditions and complications were evaluated six months later. Results:After treatments for six months, the physiological functions were improved and the dose of Madopa was reduced and the total effective rate was 66.7%. Conclusion: After acupuncture treatments in PD patients, the therapeutic effects of levodopa were enhanced, with its dose and complications reduced.

Objective] To discuss the rule of operation of heaven and earth on the basis of Five Yun and Six Qi and explore the importance on Yun Qi theory. [Method] Using the method of literature studies to explore the rule of Yun Qi theory and operation of heaven and earth. [Result] The theory of Five Yun and Six Qi holds the idea that the Qi of heaven and earth is athletic and the movement is regular.Five Yun concludes Big Yun and Small Yun.Big Yun is Sui Yun,five years a cycle according to the order of‘ wood,fire,earth,gold,water’.Six Qi concludes six steps and moves in circles.Heaven Qi goes left and Earth Qi goes right.The forms of motion concludes QiJiao movement,Sui Yun up and down and so on.Whether the form is normal or not relates much to the nature climate and the human morbidity.[Conclusion ]The theory of Five Yun and Six Qi shows the rule of climate created by the operation of heaven and earth.The regular movement of Five Yun and Six Qi varies a lot,making impact on nature climate and the human morbidity,which is the incisive meaning of the theory of Five Yun and Six Qi in Nei Jing.

Objective] To discuss the calendar background of Five Yun and Six Qi and know the background basis of Five Yun and Six Qi from the calendar feature of “ Nei Jing”. [Methods ] Using the method of documents index and collection and research to explore the form of calendar and the relationship between the manifestation mode and Five Yun and Six Qi in “ Nei Jing”, application of Yun Qi theory. [Results] The ancient calendar was created on the basis of astronomical phenomena,showing the change rule of the universe.The calendars in “ Nei Jing”conclude Taichu,Sifen,October Taiyang.Yun Qi theory flexibly uses the October Taiyang which is unified with Taichu and Sifen.The ways “ Nei Jing” display calendar are criterion measurement,clepsydra measuring time,sixty Jai Zi and so on.[Conclusion ]Five Yun and Six Qi built on the basis of calendar Taichu, Sifen, October Taiyang and the interpretation of calendar background has great significance on the study of Yun Qi theory.

[Objective] To study Yi Pian of Su Wenand its author. [Method] Using the method of documents index and collection and research to make comprehensive texual research onYi Pian of Su Wento prove the origin from the aspect of term and verb and rhetoric and so on. [Result]Yi Pian of Su Wenis the work after Tang Dynasty,quoting fromXuan Zhu Mi Yu.The rhetoric of it is not the usage before Han Dynasty,for example,black corps,green corps,red corps and so on.We can see the usage of Jia Ling in the work,which was begun fromShang Han Za Bing Lunrather than Nei Jing.The understanding of Yun Qi theory inherited from the theory of Wang Bing.Many therapeutic methods were created by LIU Wenshu instead of WANG Bing orNei Jing. LIU Wenshu wroteSu Wen Ru Shi Yun Qi Lun Aowhich was based on seven sheets of Yun Qi and the theory of WANG Bing,possessing the theory basis ofYi Pian of Su Wen.[Conclusion] Thus we regarded theYi Pian of Su Wenas the work of LIU Wenshu who had made a great contribution to the theory of Five Yun and Six Qi.Su Wen Ru Shi Yun Qi Lun Aoclarified the truth of Yun Qi by plotting,creating Gan Zhi Qi Yun and Si Tian Jue. LIU Wenshu made the theory of Tian Di Jia Zi ,which was founded inXuan Zhu Mi Yu,as the theoretical foundation of'transformation of plague in three years'.He developed the theory and put forward the treatment method.

Default-Mode Network (DMN), a new concept that has been put forward during researches of the complicated brain metabolism , has brought great significance to the studies of resting state brain function .A large quantity of studies on DMN of neurology and psychiatry diseases have been carried out recently .In this review paper , we are trying to give a detailed explanation of DMN and its recent research progresses in neurology and psychiatry diseases .

The N-terminal tail of histone exposed to the surface of nucleosomes could be covalcnfly modificated. Chromatin condensation is controlled by modification of the amino acid residues in the histone effects functionally on the nuclear processes and DNA expression. A large number of study show that improper change of the state of methylations in lysine and arginine side chains of histone can induce hematological malignant. Modulation of histone methylation can inhibit cell cycle and induce apoptosis in hematological malignant ceils.

Objective To summarize the clinical experience in repair of aortic arch obstruction associated with intracardiac anomalies in children retrospectively.Methods From March 2010 to March 2014,73 children diagnosed as coarctation of the aorta (CoA,n =68),interrupted aortic arch (IAA,n =3),and double aortic arch with CoA (n =2) underwent surgical management.Six of them were complicated with complex intracardiac anmalies,including tetralogy of Fallot (TOF,n =2),transposition of great arteries (TGA,n =1),total anomalous pulmonary venous connection (TAPVC,n =1),double outlet of right ventricle (DORV,n =1),and Shone's syndrome (n =1) ; the rest 67 patients were associated with ventricular septal defect (VSD) and other simple anomalies.Twenty eight cases had hypoplasia of the aortic arch.All the patients had one-stage repair except for one.The aortic arch reconstruction was end to end anastomosis between the descending aorta and the arch in 42 patients,end to side anastomosis in 22,and the aortic arch were enlarged using autologous pulmonary artery patch in 9.The associated intracardiac anomalies were repaired in the same stage.Results There were 2 deaths.The operative mortality was 2.7％.Renal failure was occurred in 2 cases who were cured afterwards by peritoneal dialysis.All survivors were followed up for 3 ～ 36 months,anastomotic restenosis was found in 1 case who underwent reoperation 14 months after the first operation.No neurological complications were occurred.Conclusions One-stage complete correction of CoA and IAA with intracardiac anomalies through median sternotomy can achieve excellent short-and mid-term surgical results.

Objective To explore the role of JNK signaling pathway in epithelial mesenchymal transition (EMT)process of human alveolar epithelial cells A549 induced by TGF‐β1 in vitro.Methods Human alveolar epithelial cells (A549)cultured in vitro were divided randomly into three groups :normal group ,TGF‐β1 group ( treated by TGF‐β1 with 10 ng/mL)and inhibitor group (treated by 10 ng/mL TGF‐β1 and 20 μmol/L Sp600125).Morphological observation on the cells was performed under light microscope after culturing in 3% serum medium for 72 h. The expression of E‐cadherin (E‐cad ,a epithelial cell marker) ,α‐smooth muscle actin (α‐SMA ,a mesenchymal cell marker)and Collagen fibers Ⅰ(ColⅠ ,a mesenchymal cell marker)were tested by RT‐PCR.The level of JNK phosphorylation (p‐JNK)was detected through Western blot.All experiments were repeated three times at least.Results The normal human alveolar epithelial cells (A549)cultured invitro were arranged closely like peb‐bles.E‐cad expressed at a certain level ,while the expression ofα‐SMA ,ColⅠand p‐JNK was weakly detected.In TGF‐β1 group , the cells were spindle‐shaped ,the expression of E‐cad was reduced ,while the expression ofα‐SMA ,ColⅠand p‐JNK was signifi‐cantly increased 72 h after treatment of TGF‐β1. However ,compared with TGF‐β1 group ,spindle‐shaped cells in the inhibitor group were recovered after 72 h being treated by TGF‐β1 and Sp600125 ,the expression of E‐cad was increased and the expres‐sion levels of α‐SMA ,ColⅠand p‐JNK were significantly decreased 72 h after treatment with TGF‐β1 and Sp600125 in inhibitor group. As compared with normal group ,the shape of the cells in inhibitor group was prolate ,and the expression of E‐cad ,α‐SMA ,ColⅠand p‐JNK was not significantly different.Conclusion JNK signaling pathway is related to the process of EMT of human alveolar epithelial cells induced by TGF‐β1. Sp600125 ,a special inhibitor of JNK ,could validly restrain the process.

Objective To investigate the clinical effects and complications of modified radical mastectomy and breast conserving operation for breast cancer.Methods 110 cases of breast cancer were randomly divided into the two groups,55 patients in each group,the control group took the modified radical mastectomy,while breast conser-ving operation were carried out in observation group,the clinical efficacy and incidence of complications of two groups were observed and compared.Results The operation time,intraoperative blood loss,length of incision and hospitali-zation time of the observation group were (98.47 ±8.65)min,(82.59 ±4.86)mL,(4.80 ±0.87)cm and (8.66 ± 1.77)d,significantly less than (156.52 ±10.23) min,(125.23 ±6.85) mL,(12.25 ±2.03) cm and (15.23 ± 1.85)d in the control group (t=8.12,7.58,9.88,8.72,all P<0.05);3 years survival rate,the rate of distant me-tastasis and local recurrence rate of the two groups had no significant difference (χ2 =1.35,2.03,1.82,all P>0.05);The incidence of complications of the observation group was 3.63%,significantly lower than 18.18% of the control group (χ2 =8.25,P<0.05).Conclusion Breast conserving operation has a significant efficacy for breast cancer,with less trauma,quicker recovery,fewer complications,which is worthy of extensive promotion and application in clinical practice.

Objective:To observe the effect of subtle adjustment of the cervical spine combined with Shu Jing Ding Xuan (Neck-relaxing and Dizziness-alleviating) Decoction for cervical vertigo.
Methods:An open-label, randomized and parallel controlled clinical study was designed. Subtle adjustment of the cervical spine combined with Shu Jing Ding Xuan (Neck-relaxing and Dizziness-alleviating) Decoction was used for patients in the treatment group, whereas subtle adjustment alone was used for patients in the control group. The results in the two groups were statistically analyzed after two courses of treatment.
Results:The recovery rate and total effective rate in the treatment group were 20.6%and 88.2%respectively, versus 14.7%and 73.5%in the control group. The inter-group differences were statistically significant (both P<0.01).
Conclusion: Subtle adjustment of the cervical spine combined with Shu Jing Ding Xuan (Neck-relaxing and Dizziness-alleviating) Decoction is better than subtle adjustment alone for cervical vertigo.