No abstract available.
Apoptosis* ; Prostate* ; Prostatic Hyperplasia* ; Prostatic Neoplasms* ; Proto-Oncogene Proteins c-myc*

Intra-uterine fracture of normal bone is extremely rare. It was reported few cases in the other contries, but it was very rare in Korea. It is difficult to distinguish it from birth fracture and the other fractures or deformities seen at birth. The authors experienced a case of intra-uterine fracture of the femur in the middle third of the shaft, with abundant callus formation in infant without serious injury to the mother.
Bony Callus ; Congenital Abnormalities ; Femur ; Humans ; Infant ; Korea ; Mothers ; Parturition

No abstract available.
Animals ; Immunohistochemistry* ; Neurons* ; Rats* ; Substantia Nigra*

Triple arthrodesis was performed on 167 feet in 153 patients at the Department of Orthopaedic Surgery, Seoul National University Hospital, during the 19 years from July 1957 to March 1976. Review of statistics, technical problems, and complications has led to following conclusions. 1) Of the total of 167 feet, residual poliomyelitis was the most common etiology with 127 feet (76%). 2) The youngest age was 5 years and the oldest 54 years, the 12–17 year group with 84 feet occupying half of the cases. 3) 79 feet (46.7%) had equinovarus deformity and 27 feet had equinocavovarus. 13 feet had no deformities. 4) Hoke's lazy S incision was utilized in 110 feet and Olliers incision in 57 feet. Hokes technique was employed in 118 feet and Lambrinudi's technique or its modification in 44 feet, while in the 5 feet without deformity exeresis alone was performed. Steinmann pins were used in 121 feet for temporary internal fixation and staples were used in 39 feet. 7 feet had no internal fixation. The senior author (D.Y.L.) routinely employs Hoke's incision, Hoke triple arthrodesis and Steinmann pin fixation, while when there is no deformity simple exeresis may be performed. 5) In our opinion, Hoke triple arthrodesis can correct any deformity and is particularly suitable in severely deformed rigid feet, since excision and replacement of the head of the talus affords better exposure and mobilization as well as easier set-up of the foot. 6) Whenever necessary, triple arthrodesis was combined with tendo Achilles lengthening, percutaneous plantar fasciotomy, posterior capsulotomy, medial or posteromedial release, subtalar and midtarsal wedge osteotomy, tibiotalar arthrodesis, supramalleloar osteotomy, and transmetatarsal osteotomy, followed by cast wedging or tendon transfers if indicated. 7) There was no nonunion in our cases. Clinically significant skin necrosis and wound sloughing occurred in 8 feet, gross postoperative infection in 2 feet, secondary osteoarthritis of the ankle in 2 feet, significant residual equinus deformity in 8 fret(in seven tendo Achilles lengthening was not done and in the one with tendo Achilles lengthening the deformity had been extreme and rigid), residual varus deformity in 3 feet, and residual valgus in 1 foot. These major complications occurred mostly in older children and adults, in whom deformities were severe and rigid and extensive surgery was necessary in order to achieve adequate correction. In such feet, correction is extremely difficult and greater risks of a variety of complications demand meticulous attention to technical details and postoperative care.
Adult ; Ankle ; Arthrodesis ; Child ; Clubfoot ; Congenital Abnormalities ; Equinus Deformity ; Foot ; Head ; Humans ; Necrosis ; Osteoarthritis ; Osteotomy ; Poliomyelitis ; Posterior Capsulotomy ; Postoperative Care ; Seoul ; Skin ; Talus ; Tendon Transfer ; Wounds and Injuries

Initial success with total hip arthroplasty on those severely crippled, painful hips in elderly people has prompted its application to a broad variety of conditions; namely, primary and secondary osteoarthritis, rheumatoid arthritis, avascular necrosis of the femoral head, and failed arthroplasties. Some have attempted it on previously arthrodesed hips, while others have successfully treated failed Girdlestone by total hip arthroplasty. To date, however, total hip arthroplasty remains essentially a procedure for older people. It has been greatly emphasized that total hip arthroplasty on 29 cases of residual hips secondary to pyogenic or tuberculous infection occurred during childhood. All were young adults ranging from 17 to 56 years of age, with a mean age of 32. 1 years. None of the hips had active infection at time of operation, although in 2 cases biopsy, at the arthroplasty, revealed chronic granulomatous inflammation. The hips had bony or fibrous ankylosis,or pseudarthrosis with dislocation, and presented marked flexion deformity, bony hypoplasia, limb shortening, and muscle atrophy. In 6 cases, arthroplasty was preceded by preliminary anterior soft tissue release and osteotomy of the ankylosis, followed by skeletal traction. In one case, anterior release through a separate incision was carried out on the same setting prior to arthroplasty. Lateral approach with trochanteric osteotomy was routinely employed, except in two in which the hip was approached posteriorly without trochanteric osteotomy. Trapezoidal-28 prosthesis was used in 17 cases, 5 of which were of short neck, thin stem sized, 7 of which were of medium neck small stem sized. Muller prosthesis was used in 8 cases, 7 of which were of standard neck standard stem sized. One small straight stem Charnley prosthesis failed and was later replaced by a custom-made Charnley stem prosthesis. Two offset bore ovoid cup and Charnley extra-small stem were used. In addition to routine preoperative, intraoperative, and postoperative antibiotics, Kanamycin was mixed to cement routinely. There was no postoperative wound infection. In two cases with presumably healed tuberculosis, infection recurred after arthroplasty. In all the remaning hips, painless serviceable function was restored, especially in view of diverse range of motion in orientals. In the oriental life style, the importance of a mobile hip cannot be overstressed.
Aged ; Ankylosis ; Anti-Bacterial Agents ; Arthritis, Rheumatoid ; Arthroplasty ; Arthroplasty, Replacement, Hip ; Biopsy ; Congenital Abnormalities ; Dislocations ; Extremities ; Femur ; Head ; Hip ; Humans ; Inflammation ; Kanamycin ; Life Style ; Muscular Atrophy ; Neck ; Necrosis ; Osteoarthritis ; Osteotomy ; Prostheses and Implants ; Pseudarthrosis ; Range of Motion, Articular ; Surgical Wound Infection ; Traction ; Tuberculosis ; Young Adult

Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Dignosis of EPSC should be considered when the cervico-vaginal smear reveals numerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.
Adenocarcinoma ; Adenocarcinoma, Papillary ; Diagnosis ; Polycystic Kidney, Autosomal Recessive*

No abstract available.
Adrenocorticotropic Hormone*

Chondromalacia patella is a symptom complex characterized by aching pain behind the knee cap, retropatella tenderness that is aggravated by the stair climbing. Malalignment is an important factor causing chondromalacia patella. And to recognize it, is important in the diagnosis and treatment. We studied 3 parameters in the chondromalacic knee and nonchondromalacic knee and the following results was obtained. l. In nonchondromalacic knee, the sulcus angle is 141° 7′ and the congruence angle is −5° 1′ 2. In chonduomalacic knee the sulcus sagle is 139° 2′ and the congruence angle is +5° 3′ 3. In the group with abnormal congruence angle, there was much degenerative changes in the patellofemaral joint. So, it can be inferred that chondromalacia is a precursor of the osteoarthritis and the patient with abnormal congruence angle should be treated actively at the early stage if the conservative treatment had failed.
Cartilage Diseases ; Diagnosis ; Humans ; Joints ; Knee ; Osteoarthritis ; Patella ; Sesamoid Bones

We report a diabetic woman who developed paroxysmal hemichorea during an episode of non-ketotic hyper-glycemia. A MRI showed a high signal intensity on T1-weighted images and a low signal intensity on T2-weighted images in the contralateral putamen. SPECT on the 30th day after the onset revealed an increased blood flow in the contralateral striatum. Although these abnormalities in the left putamen are considered to be the cause of her involuntary movement, the exact pathophysiological mechanisms of these abnormalities are not yet clear and further investigations are needed.
Dyskinesias ; Female ; Humans ; Hyperglycemia* ; Magnetic Resonance Imaging ; Putamen ; Tomography, Emission-Computed, Single-Photon

BACKGROUND: The severity of several chronic inflammatory diseases was reported to be associated with polymorphism of the IL-1 receptor antagonist gene(IL-lrn). OBJECTIVE: This study was performed to study the polymorphism of the IL-1rn in vitiligo and in the normal Korean population. METHODS: Thirty one cases of vitiligo and seventy nine normal Koreans as control were studied for the polymorphism of IL-1 rn. RESULTS: The frequency of allele 2 of the IL- I rn in 31 patients with vitiligo was compared with that of the 79 healthy controls. The frequency of allele 2 was 1.6% in vitiligo patients and 3.8% in the normal controls. CONCLUSION: There was no significant difference in the frequency of allele 2 between the vitiligo patients and normal controls.
Alleles ; Humans ; Interleukin-1* ; Vitiligo*