No abstract available.
Chinchilla* ; Vestibular Nerve* ; Vestibular Nuclei*

The 5 cases of human fetal liver aged from 11 to 23 weeks of gestation were investigated for the ultrastructure of sinusoidal wall by electron microscopy. The endothelial cells deficient in basement membrane formed almost all the part of sinusoidal wall. The cells were continued with neighboring cells by intercellular junction, and overlapped them and exhibited to maintain unfenestrated capillary wall, which was different from those with fenestra in adults. The cells were found to have coated pits on luminal side and several various vesicles in the cytoplasms. The cells were related with transcellular migration of reticulocytes and acidophilic erythroblastes, which penetrated into the endothelial cytoplasm to form transient migrating pore closing after the migration into sinusoidal lumen. The perivascular cells were present at perivascular space and surrounding the sinusoid discontinuously. The Kupffer cells were easily identified with filipodia and lamellipodia and with phagosome of nuclei enucleated from acidophilic erythroblasts.
Adult ; Basement Membrane ; Capillaries ; Cytoplasm ; Endothelial Cells* ; Erythroblasts ; Erythrocytes ; Humans* ; Intercellular Junctions ; Kupffer Cells* ; Liver* ; Microscopy, Electron ; Phagosomes ; Phenobarbital ; Pregnancy ; Pseudopodia ; Reticulocytes

Congenital pseudarthrosis of the tibia is a relatively rare but well known entity. Aside from the fibula, which is aften associated with tibia, the clavicle is probably the next preponderant site. Congenital pseudoarthrosis of other bones are extremely rare. We have found 10 cases of congenital pseudarthrosis of either the radius or the ulna in the English literature. Only one case of congenital pseudarthrosis of both bones of the forearm has been reported to our knowledge, A 30 year old man with congenital pseudarthrosis of the radius and the ulna associated with neurofibromatosis was seen at Seoul National University Hospital in March, 1985. Osteosynthesis was successful on the radius, but failed on the ulna. The distal fragment of the ulna eventulally disappeared altogether.
Clavicle ; Fibula ; Forearm ; Neurofibromatoses ; Pseudarthrosis ; Radius ; Seoul ; Tibia ; Ulna

No abstract available.
Leiomyoma* ; Thrombocytosis*

Thelazia callipaeda, parasitic in the eye of 24 years old Korean male, was extracted from the left eye of the patient in Seoul, Korea. We confirmed that as T. callipeada morphologically, based on the descriptions of Hsu and other literature. We presents the 7th human thelaziasis case in Korea with the historical review of the literature.
parasitology-helminth-nematoda ; Thelazia callipaeda ; thelaziasis ; case report

PURPOSE: This study focused on in vitro cell differentiation and surface characteristics in a magnesium coated titanium surface implanted on using a plasma ion source. MATERIALS AND METHODS: 40 commercially made pure titanium discs were prepared to produce Ti oxide machined surface (M) and Mg-incorporated Ti oxide machined surface (MM). Surface properties were analyzed using a scanning electron microscopy (SEM). On each surface, alkaline phosphatase (ALP) activity, alizarin red S staining for mineralization of MC3T3-E1 cells, and quantitative analysis of osteoblastic gene expression, were evaluated. Actin ring formation assay and gene expression analysis of TRAP and GAPDH performing RT-PCR were performed to characterize osteoclast differentiation on mouse bone marrow-derived macrophages (BMMs). RESULTS: MM showed similar surface morphology and surface roughness with M, but was slightly smoother after ion implantation at the micron scale. M was more hydrophobic than MM. No significant difference between surfaces on ALP activity at 7 and 14 days were observed. Real-time PCR analyses showed similar levels of mRNA expression of the osteoblast phenotype genes; osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP), and collagen 1 (Col 1) in cell grown on MM at 7, 14 and 21 days. Alizarin red S staining at 21 days showed no significant difference. BMMs differentiation increased in M and MM. Actin ring formation assay and gene expression analysis of TRAP showed osteoclast differentiation to be more active on MM. CONCLUSION: Both M and MM have a good effect on osteoblastic cell differentiation, but MM may speed the bone remodeling process by activating on osteoclast differentiation.
Actins ; Alkaline Phosphatase ; Animals ; Bone Remodeling ; Cell Differentiation ; Collagen ; Gene Expression ; Integrin-Binding Sialoprotein ; Macrophages ; Magnesium* ; Mice ; Microscopy, Electron, Scanning ; Osteoblasts* ; Osteocalcin ; Osteoclasts* ; Osteopontin ; Phenotype ; Plasma ; Real-Time Polymerase Chain Reaction ; RNA, Messenger ; Surface Properties ; Titanium*

No abstract available.
Down Syndrome*

The stature, span, lower limb length, sitting height, head length and head breadth of 411 Korean elementary school girls ranging from 7 to 10 years of age were measured biometrically and the indices among all of the items were calculated to investigate the physical growth status. The following conclusion have been obtained. 1. The average statures were 117.40cm in 7, 122.72cm in 8, 126.76cm in 9 and 132.92cm in 10 years of age groups, and the annual average stature growth was 5.17cm. 2. The average spans were 113.12cm in 7, 118.70cm in 8, 124.26cm in 9, 130.46cm in 10 years of age groups, and the annual average span growth was 5.78cm. 3. The average lower limb lengths were 62.96cm in 7, 66.80cm in 8, 69.09cm in 9 and 73.13cm in 10 years of age groups, and the annual average lower length growth was 3.39cm 4. The average sitting heights were 65.82cm in 7, 68.56cm in 8, 70.18cm in 9 and 73.13cm in 10 years of age groups, and the annual average sitting height growth was 2.43cm. 5. The average body weights were 21.22kg in 7, 24.13kg in 8, 25.54kg in 9 and 29.27kg in 10 years of age groups, and the annual average body weight growth was 2.68kg. 6. The average head lengths were 16.29cm in 7, 16.38cm in 8, 16.47cm in 9 and 16.60cm in 10 yeras of age groups, and the annual average head length growth was 0.10cm. 7. The average head breadth were 14.50cm in 7, 14.65cm in 8, 14.67cm in 9 and 14.81cm in 10 years of age groups, and the annual average head breadth growth was 0.10cm. 8. While both relative span and lower limb length increased with age and the relative sitting height slightly decreased with age. 9. The relative body weight increased with age. 10. The head type depended on cephalic index was belonged to hyperbrachycephaly, and showed no differrences with age in all of the groups. 11. The relative span was over 96 in all age groups, and the value increased slightly with age. 12. The average annual growth showed remarkable high value between 9 to 10 years of age in the items of stature, span, lower limb length, sitting height and body weight.
Body Weight ; Female* ; Head ; Humans ; Lower Extremity

The influences of adrenal corticosteroid on the development and regression of neurons of dentate and hippocampus were studied by adrenalectomy and steroid overload in neonatal rats. The results obtained were as follows. 1. The cell death occurred naturally in numerous dentate granule cells and hippocampal pyramidal cells. 2. The number of dentate granule cells undergoing cell death decreased by injection of adrenal corticosteroid, but increased in adrenalectomized rat brains. The changes occurred prominently at postnatal day 6. 3. The number of hippocampal pyramidal cells undergoing cell death decreased in CA3 region by injection of adrenal corticosteroid, but was not changed in adrenalectomized rat brains. However, other regions exhibited no change by adrenal corticosteroid and adrenalectomy. 4. The cell death of pyramidal cells of CA3 region occurred in close relationship with the cell death of dentate granule cells, which was different from other CA regions. In summary, the cell death of dentate and hippocampal neurons occurred naturally but seemed to be influenced by other factors as well as adrenal corticosteroid.
Adrenalectomy ; Animals ; Brain ; Cell Death ; Hippocampus* ; Neurons* ; Pyramidal Cells ; Rats*

To understand the mode of transmission in clonorchiasis, a survey was made in Kim-hae Goon, South Kyong-sang Do (=Province). The mathematical analysis of the age prevalence was done on the egg positive rates. And another analysis for the comparison was also made to the cited data from two areas, North Kyong-sang Do and Ko-yang Goon, Kyong-gi Do. Some catalytic models of H. Muench (1959) were applied to the observed age prevalence. Because the both parameters, such as force of infection(a) and loss of positivity(b) were considered to be constant for a long period in the surveyed area, the two stage catalytic model by Muench was chosen to the analysis. In the surveyed area, Kim-hae Goon where the egg positive rates were 56.2 percent and 61.2 percent (by Kim, 1974), the constant values of 'a' were found to be 0.051 and 0.089 respectively. In other words, the force of infection was 51, 89 per 1,000 susceptibles. The values of 'b' were found to be 0.006 and 0.005. This means that the rates of disappearance from egg positive cases to negative were 6 and 5 per annum per l,000 positive cases in above area. Therefore, the two catalytic curves were expressed by the following equations, y = 1.133 {e(-0.006t) - e(-0.051t)} and y = 1.047 {e(-0.005t) - e(-0.089t)} respectively. In the cases of North Kyong-sang Do and Ko-yang Goon, Kyong-gi Do where the egg positive rates of clonorchis shown as 27.7 percent and 15.2 percent by Shin (1964) and Kim (l974), the curves were expressed by y = 1.769 {e(-0.010t) - e(-0.034t)} and y = 2.857 {e(-0.020t) - e(-0.027t)} respectively. From the above mathematical analyses by age prevalence in clonorchiasis, it was considered that the mode of transmission of clonorchiasis in the surveyed area, Kim-hae Goon presented more rapid pattern than those of North Kyong-sang Do and Ko-yang Goon, Kyong-gi Do.
parasitology-helminth-trematoda ; clonorchiasis-Clnorchis sinensis ; epidemiology ; transmission