Puerarin is one of the most important effective components of Pueraria lobata which exhibited classic estrogen-like biological activities and had remarkable cardiovascular protections in vivo and in vitro experiments. These protections of puerarin are mainly exhibited on improving the myocardial cells membrane potential and arrhythmia based on effecting the Na+, K+ , and Ca2+ channels,resisting myocardial fibrosis damage, diastolic effect on blood vessels, promoting angiogenesis, resisting calcification and atherosclerosis, improving blood flow, antiplatelet aggregation, reducing lipid and resisting diabetes. The main mechanisms are to improve the membrane potential and reduce cardiovascular damage caused by inflammation, oxidative stress and apoptosis, and the main regulated signal pathways are the PI3K/Akt, the NF-kappa B and the caspases.
Animals ; Cardiovascular Diseases ; genetics ; metabolism ; prevention & control ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Isoflavones ; pharmacology ; Oxidative Stress ; drug effects ; Protective Agents ; pharmacology ; Pueraria ; chemistry ; Signal Transduction ; drug effects

In medical equipment purchasing process, massive non-price factors' influences conduce to quite quantities of risks in the medical equipment purchase. To control the risks,this paper proposes the project management, the supplier management, the equipment traceability management and related suggestions. Management on purchaser is also discussed, which mainly includes professional stress analysis and the countermeasures research.

Objective To investigate the change of serum resistin levels in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).MethodsPolysomnography(PSG)was performed in 58 patients with OSAHS and in 26 controls without differences in age and BMI.Serum resistin levels were measured by ELISA.Results(1)Serum resistin levels were significantly higher in patients with OSAHS than those in control group.(2)FPG levels were significantly higher in patients with OSAHS than those in control group.(3)TG levels were significantly higher in patients with OSAHS than those in control group.(4)Serum resistin levels were correlated positively with FPG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(5)Serum resistin levels were correlated positively with TG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(6)Serum resistin levels were correlated positively with BMI in OSAHS.(7)Serum resistin levels were correlated negatively with LSaO2 in OSAHS.(8)Serum resistin levels were correlated positively with AHI in OSAHS.ConclusionDetermination of serum resistin levels may be the predictors of the severity of OSAHS and it also contributes a lot taking measures to prevent and control the OSAHS complication occurrence and reduce the mortality.

ObjectiveTo analysis the current conditions of the main chronic disease,satisfaction,reactive and trust,then to make the control policy in community health management base in China.Method Using the questionnaire by oneself,which the contents include prevalence,understand rate,management rate,behavior correct rate,control rate,medicine obey and satisfaction,reactive and trust of 2009 the chronic disease in 2009.ResultsThe total investigate people was 1 189 456.The hypertension prevalence is 8.01％,the diabetes prevalence is 4.41％.To compare with Shanghai and Jilin in 6 aspects,the prevalence,understand rate,management rate,control rate,medicine obey rate is higher in Shanghai.But behavior correct rate is lower in Jilin.Survey of hypertension prevalence rate was decreased,awareness,management,rates,rates of behavior modification,medication compliance rates and control rates of growth from 2009 to 2010.Satisfaction,responsiveness and trust indicators investigated a total of 2268 people,the process of service satisfaction to 93.43％,93.78％ overall satisfaction; to have the privacy of reactivity to 94.41％ of the basic amenities and clean comfortable response of the 90.45％ ; of treatment services for the 92.59％confidence,the confidence of the cost for the 93.98％ of the overall trust in institutions is 92.76％.ConclusionsThe government must take main principle in chronic disease control.We must enhance base construct of community health management and increase management level of chronic disease.We must enhance practitioner's culture ang increase knowledge of chronic disease management.

Total 2625 cases of pulmonary sequestration were collected from literatures of Chinese National Knowledge Infrastructure from 1998 to 2008. The age, gender, clinical symptoms, chest CT scan,chest X-ray findings, lesion location, supplying artery, venous reflux, and preoperative misdiagnosis of 2625 cases were retrospectively reviewed. The male: female ratio of all cases was 1.58: 1. The main clinical symptoms of pulmonary sequestration were cough, sputum, fever, hemoptysis and chest pain, but 13.36% patients were asymptomatic. Chest CT scan showed pulmonary massive lesions (49.00%), pulmonary cystic lesions (28.57%), pulmonary cystic-solid lesions ( 11.57% ), and flaky shadows (7.96%). Pulmonary sequestration mainly located in the lower lobe; 66. 43% located in the left posterior basal segments, and 20. 16% located in the right posterior basal segments. Pulmonary sequestrations were divided into three types, intralobar sequestration (83. 84% ), extralobar sequestration ( 16.03% ), and mixed sequestration (0.13% ). The arterial supply was mainly from branches of thoracic aorta (76. 55% ) and abdominal aorta (18.47%). The clinical manifestations of pulmonary sequestration were various, so the preoperative misdiagnosis rate was as high as (59 ± 20) %. We should take full advantage of clinical symptoms, imaging findings and location characteristics to improve the preoperative diagnosis rate.

Objective To evaluate the timing,feasibility and necessity of early laparoscopic cholecystectomy (LC) in management of patients with mild to moderate acute pancreatitis with gallbladder stones.Methods The clinical data of 75 patients with mild to moderate acute pancreatitis and gallbladder stones treated from September 2010 to August 2014 in our hospital were analyzed retrospectively.32 patients underwent LC within 48 hours of the pancreatic attack.The results were compared with those from 43 patients with delayed LC.Results All the patients were operated by experienced surgeons.There were no significant differences between the two groups in operation time,postoperative complications,intraoperative blood loss,conversion rates,white blood cell count,percentage of neutrophils and blood amylase before and after the operation (P ＞0.05).Patients who received delayed LC had longer hospital stay [(10.6 ± 1.3) vs (17.1 ± 1.8),P ＜ 0.05].The readmission rate in patients with delayed LC was 30.2％ (13/43),and most admissions occurred within 2 ～4 weeks of hospital discharge.In patients with early LC,one patient developed necrotic pancreatitis and died of septic shock.All the remaining patients were cured.Conclusions It is safe,feasible and necessary to perform LC within 48 h in patients with mild to moderate acute pancreatitis and gallbladder stones.Such patients have a high readmission rate and the best timing of delayed LC is within 2 ～ 4 weeks after discharge from hospital.

ObjectiveTo observe the effect of electroacupuncture at Neiguan (PC6) and Shenmen (HT7) on heart rate variability (HRV) in patients with post-cerebral-infarction sequelae.MethodEighty patients were randomized into two groups, 40 cases in each group. The control group was intervened by anti-platelet aggregation and other ordinary symptomatic treatment based on Western medicine, while the treatment group was by electroacupuncture at Neiguan and Shenmen in addition to the treatments given to the control group.ResultThere were no significant differences in comparing the HRV indexes between the two groups before intervention (P>0.05); while the HRV indexes in the treatment group were superior to that in the control group after intervention (P<0.05). HRV indexes were improved after intervention in the treatment group (P<0.05); of the indexes, only SDNN was improved after intervention in the control group (P<0.05), and the rest indexes were insignificantly changed (P>0.05).Conclusion Electroacupuncture at Neiguan and Shenmen can significantly reduce HRV in patients with post-cerebral infarction sequelae.

The effects of acute cyanide intoxication on the monoamine transmitters of the brain of the rats were observed.The level of dopamine (DA),norepinephrine(NE),serotonin (5-HT),and 5-hydroxyindoleacetic acid (5-HIAA) in the rat brain was measured 3,5,10,30,45 and 60 minutes after the animals were poisoned with intraperitoneal injection of NaCN.It was found that the level of the 4 monoamine transmitters was doseage-dependentty decreased and a lower dosage of 2.36 mg/kg of NaCN increased the level of DA and NE at the 45th minute after intoxication.It was also found that cyanide-induced convulsions were accompanied with a significant decrease of brain monoamine transmitters.It is believed that the changes of the level of mona-mine transmitters in the brain may play a role in the central intoxication of cyanide.

Objective: To evaluate shaping ability of nickel-titanium rotary instruments (Hero 642) in curved root canals. Methods:The computer assistant measure system of simulated root canal was used for quantitative analysis of root shape in eight simulated root canals during nickel-titanium rotary instruments (Hero 642) shaping process. Results:Nickel-titanium rotary instruments (Hero 642) could keep the curved angles in simulated canals very well. The cutting of Hero 642 in curved root canals was balanced and there was almost no transportation of canals central lines when the simulated canals were prepared to 0.02 taper 25~# and 30~# files. Conclusion:Nickel-titanium rotary instruments (Hero 642) has good shaping ability. In preparation of highly curved canals, the master apical file (MAF) may be Hero 642 0.02 taper 30# files.

AIM: To observe the effect of tranilast on experimental COPD rats in terms of airway remodeling. METHODS: Forty eight SD rats were divided into two groups in random: untreated model group, tranilast-treated group. Another eight rats were selected as control group. The COPD rat model was established by passive smoking and intratracheal instillation of lipopolysaccharide (LPS) and then treated with sterile saline or tranilast (400 mg?kg~ -1 ?d~ -1 ) respectively. Eight rats in each group were killed in 7th, 14th, 28th day after the beginning of proceeding. Bronchoalveolar lavage fluid (BALF) was collected, and the total and differential cells were counted. The distribution and the ratio of type I to type III collagen in the lung tissue were determined using a sirius red polarizing microscopy morphometry method. Lung tissues were observed by hemotoxylin and eosin stain, then the image analysis were made. RESULTS: The total cells and the AM ratio in BALF of tranilast-treated group significantly decreased in comparison with those in model group (P