1.Statistical Study on Pediatric Emergency Room Patients.
Hwa Young KIM ; Yong Tai SUH ; Young Yun CHOI
Journal of the Korean Pediatric Society 1984;27(4):378-383
No abstract available.
Emergencies*
;
Emergency Service, Hospital*
;
Humans
;
Statistics as Topic*
2.Serum and Urine Zinc Values in Infectious Diseases.
Yong Tai SUH ; Hwa Young KIM ; Jai Sook MAH ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1984;27(3):237-245
No abstract available.
Communicable Diseases*
;
Zinc*
3.The Thoracic Radiculopathy in SAPHO Syndrome.
Seok HAN ; Tai Hyoung CHO ; Se Hoon KIM ; Dong Jun LIM ; Jung Yul PARK ; Yong Gu CHUNG ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2001;30(11):1320-1323
SAPHO syndrome is an acronym for an increasingly recognized syndrome of synovitis, acne, pustulosis, hyperostosis, and osteitis. Most of the previously reported case are from Japan and Europe. The authors report a case of SAPHO syndrome in Korean female who presented with extrasternal neurologic symptoms. A 60-year-old female with thoracic and right chest wall pain presented with the sternocostoclavicular hyperostosis, and recurrent aseptic osteitis. Previously, she had hystrectomy and thyroidectomy due to uterine malignancy 25 years ago. Also, she started to take medications for palm and sole pustulosis 7 days prior to admission. Through evaluation of clinical, radiological, serological studies, studies was done along with bone needle biopsy for the biological reassessment. The hyperostosis was found in the pedicles of thoracic 8, 9, 10 vertebrae and sternoclavicular joint. Radio-isotope bone scan showed an accumulation of tracer in thoracic vertebra. The bone biopsy from these site showed increased osseous turnover, thickening of trabeculae accompanied by mild acculuation of granulation tissue and round cell infiltration, compatible with mild chronic inflammation with marrow fibrosis. The patient showed good response to conservative management. The authors report a case of SAPHO syndrome with thoracic radiculopathy. It is considered that SAPHO syndrome is related to spondyloarthropathy, and appears to have benign disease process with good prognosis.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Biopsy
;
Biopsy, Needle
;
Bone Marrow
;
Europe
;
Female
;
Fibrosis
;
Granulation Tissue
;
Humans
;
Hyperostosis
;
Hyperostosis, Sternocostoclavicular
;
Inflammation
;
Japan
;
Middle Aged
;
Neurologic Manifestations
;
Osteitis
;
Prognosis
;
Radiculopathy*
;
Spine
;
Spondylarthropathies
;
Sternoclavicular Joint
;
Synovitis
;
Thoracic Wall
;
Thyroidectomy
4.Krukenberg Tumor Presenting with Brain Metastasis: A Case Report.
Taek Hyun KWON ; Tai Hyoung CHO ; Dong Jun LIM ; Jung Yul PARK ; Youn Kwan PARK ; Yong Gu CHUNG ; Hung Seob CHUNG ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2000;29(9):1267-1270
No abstract available.
Brain*
;
Krukenberg Tumor*
;
Neoplasm Metastasis*
5.The Correlation between Insertion Depth of Prodisc-C Artificial Disc and Postoperative Kyphotic Deformity: Clinical Importance of Insertion Depth of Artificial Disc.
Do Youl LEE ; Se Hoon KIM ; Jung Keun SUH ; Tai Hyoung CHO ; Yong Gu CHUNG
Korean Journal of Spine 2012;9(3):147-152
OBJECTIVE: This study was designed to investigate the correlation between insertion depth of artificial disc and postoperative kyphotic deformity after Prodisc-C total disc replacement surgery, and the range of artificial disc insertion depth which is effective in preventing postoperative whole cervical or segmental kyphotic deformity. METHODS: A retrospective radiological analysis was performed in 50 patients who had undergone single level total disc replacement surgery. Records were reviewed to obtain demographic data. Preoperative and postoperative radiographs were assessed to determine C2-7 Cobb's angle and segmental angle and to investigate postoperative kyphotic deformity. A formula was introduced to calculate insertion depth of Prodisc-C artificial disc. Statistical analysis was performed to search the correlation between insertion depth of Prodisc-C artificial disc and postoperative kyphotic deformity, and to estimate insertion depth of Prodisc-C artificial disc to prevent postoperative kyphotic deformity. RESULTS: In this study no significant statistical correlation was observed between insertion depth of Prodisc-C artificial disc and postoperative kyphotic deformity regarding C2-7 Cobb's angle. Statistical correlation between insertion depth of Prodisc-C artificial disc and postoperative kyphotic deformity was observed regarding segmental angle (p<0.05). It failed to estimate proper insertion depth of Prodisc-C artificial disc effective in preventing postoperative kyphotic deformity. CONCLUSION: Postoperative segmental kyphotic deformity is associated with insertion depth of Prodisc-C artificial disc. Anterior located artificial disc leads to lordotic segmental angle and posterior located artificial disc leads to kyphotic segmental angle postoperatively. But C2-7 Cobb's angle is not affected by artificial disc location after the surgery.
Congenital Abnormalities
;
Humans
;
Retrospective Studies
;
Total Disc Replacement
6.Primary Non-Hodgkin's Lymphomas Presenting with Extradural Spinal Cord Compression as the Initial Manifestation.
Se Hoon KIM ; Dong Jun LIM ; Tai Hyoung CHO ; Jung Yul PARK ; Yong Gu CHUNG ; Hoon Kap LEE ; Ki Chan LEE ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2000;29(10):1365-1371
No abstract available.
Lymphoma, Non-Hodgkin*
;
Spinal Cord Compression*
;
Spinal Cord*
7.Measurement of Cervical Spinal Cord Pressure Using Artificial Cord.
Tai Hyoung CHO ; Teak Hyun KWON ; Jung Yul PARK ; Yong Gu CHUNG ; Jung Keun SUH ; Hoon Kap LEE
Journal of Korean Neurosurgical Society 1998;27(3):305-308
It has long been thought that in individuals with congenitally narrower spinal canals, the risk of spinal cord injury might be increased. The purpose of the present study was to quantitatively assess spinal cord pressures in cadaveric human cervical spines with narrow and wide canals, and with normal and degenerative columns. Twelve human cadaveric cervical spine preparations were evaluated on the basis of their level of degeneration and canal size. A drop mass assembly was constructed with different combinations of masses to produce 24 possible drop combinations for each spine preparation. These resulted in input energies from 100 to 1000 'gram-centimeters'. Cadaver cervical spine was instrumented with a collagen encased artificial spinal cord and seven sensor transducer arrays recorded pressures on the cord during the impact event. The results indicated that depending on the extent and and level of degeneration, degenerated spinal columns produced distinctly different patterns of cord pressure. Normal spinal columns produced consistent patterns of high pressures under the impact site, but this decreased caudally and cranially. In specimens with narrow spinal canals, cord pressures under the impact site were significantly higher than in specimens with wide canals. For the higher drop energies(800 and 1000 'g-cm') the disparity between narrow and wide canal specimens increased. This implies that for the same inpt drop energy, the propensity for spinal cord injury is higher for narrower spinal canals than for those which are wider.
Cadaver
;
Collagen
;
Humans
;
Spinal Canal
;
Spinal Cord Injuries
;
Spinal Cord*
;
Spine
;
Transducers
8.The Effects of Nimodipine on Irradiation-Induced Apoptosis in the Rat Spinal Cord.
Se Hoon KIM ; Tai Hyoung CHO ; Dong Jun LIM ; Jung Yul PARK ; Yong Gu CHUNG ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2003;33(6):576-581
OBJECTIVE: Radiation therapy is an effective adjunctive therapy in the management of brain and spinal cord tumors. The damage to normal tissue, however, has been often the dose-limiting factor in radiation therapy. The purpose of this study is to see whether nimodipine, the one of calcium channel blockers, is effective for the prevention of irradiation-induced apoptosis in the rat spinal cord. METHODS: Sprague-Dawley rats were used: Control(n=12), Nimodipine-treated(0.5mg/kg, n=12). After nimodipine was administered intraperitoneally, the spinal cord of cervicothoracic junction was exposed to a single 10Gy dose of gamma rays using Ir-192. All spinal cords underwent histological examination at 4, 8, and 12 hours after irradiation, and apoptotic cells were detected by TUNEL assay and were determined by direct visual counting at magnification of x200. RESULTS: On the standard H-E stain, little evidence of histopathological change was noted within the 12 hours after irradiation. Both groups showed gradual increase of apoptotic cell counts with the lapse of time. But, in nimodipine-treated group, apoptotic cell counts were reduced significantly, compared to those of control group after irradiation, especially at 8 and 12 hours. CONCLUSION: The results suggest that nimodipine may have effects on the prevention of radiation-induced apoptosis in the spinal cord.
Animals
;
Apoptosis*
;
Brain
;
Calcium Channel Blockers
;
Cell Count
;
Gamma Rays
;
In Situ Nick-End Labeling
;
Nimodipine*
;
Rats*
;
Rats, Sprague-Dawley
;
Spinal Cord Neoplasms
;
Spinal Cord*
9.The Effect of Nimodipine on Experimental Spinal Cord Injury.
Tai Hyeung CHO ; Youn Kwan PARK ; Yong Ku CHONG ; Heung Seop JEONG ; Jung Keun SUH ; Hoon Kap LEE ; Ki Chan LEE ; Jeong Wha CHU
Journal of Korean Neurosurgical Society 1990;19(8-9):1184-1197
Nimodipine the potent, centrally active, clacium channel blocker, is known to increase cerebral and spinal blood flow. In the present study, the authors investigated the effect on Nimodipine on injured spinal cord. The experiment was a randomized blind study in which four groups of five cats received Nimodipine(0.05mg/kg) intravenously, and control groups of five cats received only Diluent. As a step in the investigation of the possible effect of spinal cord trauma on biochemical and ultrastructural changes in the injured cord, activities of lipid peroxidation were measured in the frozened-dried sample of the spinal cord and fine structure of the mylinated nerve fiber in the white matter were observed. An increase of lipid peroxidation level was found as early as 1 hour after the injury and the highest concentration was reached at 5 hours after the injury(P<0.01). Fine structures of the myelinated nerve fibers were changed progressively with the lapse of time after the injury. The effect of Nimodipine on lipid peroxidation and fine ultrastructural changes of myelinated nerve fibers were studied, and the result of this study revealed that Nimodipine groups showed a lower level of lipid peroxidation with statistical significance(P<0.05) and preservation of ultrastructural myelinated nerve fiber was prominent.
Animals
;
Cats
;
Lipid Peroxidation
;
Nerve Fibers
;
Nerve Fibers, Myelinated
;
Nimodipine*
;
Spinal Cord Injuries*
;
Spinal Cord*
10.The Effects of Steroid and Calcium Channel Blocker on Single High Dose Irradiation-induced Apoptosis in Rat Brain.
Geun Hoe KIM ; Se Hoon KIM ; Woo Jae KIM ; Yong Gu CHUNG ; Dong Jun LIM ; Tai Hyoung CHO ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2003;33(2):188-194
OBJECTIVE: Radiation injury includes radiation necrosis and apoptosis. The purpose of this study is whether steroids and calcium channel blockers are effective for the prevention of single high dose irradiation-induced apoptosis in the rat brain. METHODS: Eighty Sprague-Dawley rats were divided into four experimental groups: Control(nontreated, n=20), Dexamethasone-treated(0.1mg/kg, n=20), Prednisolone-treated(2mg/kg, n=20), Nimodipine-treated (0.5mg/kg, n=20). After drug was administered, the right hemisphere of rat's brain was exposed to a single 10Gy dose of gamma rays using Ir-192. All brains underwent histological examination at 1 week, 2 weeks, 4 weeks, and 8 weeks after irradiation to evaluate cortical thickness and number of apoptotic cells. Apoptotic cells were detected by TUNEL assay. RESULTS: In nimodipine-treated group, apoptotic cell count was reduced significantly, compared to that of control(non treated) group at 4 and 8 weeks after irradiation(p<0.05). The decrease of cortical thickness was reduced significantly in nimodipine-treated group, compared to that of control group(p<0.05). There was no significant changes in the number of apoptotic cells and cortical thickness in prednisolone and dexamethasone-treated groups compared with those of control. CONCLUSION: These results suggest that nimodipine treatment may have effects on the prevention of radiation-induced apoptosis. If it could be established that calcium channel blockers inhibit radiation injury, they might be useful in radiation therapy. Further investigation of calcium channel blockers including dosage effectiveness, intracellular calcium ion concentration and effects on tumor tissue are necessary to clarify the usefulness of nimodipine.
Animals
;
Apoptosis*
;
Brain*
;
Calcium Channel Blockers
;
Calcium Channels*
;
Calcium*
;
Cell Count
;
Dexamethasone
;
Gamma Rays
;
In Situ Nick-End Labeling
;
Necrosis
;
Nimodipine
;
Prednisolone
;
Radiation Injuries
;
Rats*
;
Rats, Sprague-Dawley
;
Steroids