OBJECTIVE: The purpose of this study was to investigate possible menopause related changes in circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and their relationship with insulin-like growth factor 1 (IGF-1) plasma levels, osteocalcin(Ost) and urinary deoxypyridinoline(Dpd) in either surgical menopause or natural menopause, METHOD: Seventy-two postmenopausal women (surgical menopause 48, natural menopause 24) were invited to participate in this study. In all subjects plasma IGF-1 and IGFBP-3 levels were measSURED by radioimmunoassay and Ost and Dpd were measured by enzyme linked immunosorbent assay(ELISA). RESULTS: No difference was found between mean IGFBP-3 plasma levels in the two groups studied(3,522 +/- 926 vs 3,854 +/- 569 ng/ml), while mean IGF-1 levels were significantly lower in natural menopause as compared with surgical menopause (natural 126 +/- 44 vs surgical 163 +/- 66 ng/ml, p=0.007). No difference was found between mean Ost levels in the two groups studied (natural menopause 8.0 +/- 2.9 vs surgical menopause 8,9 +/- 2.1 ng/ml, p=0.113) and mean Dpd levels in the two studied (natural menopause 6.8 +/- 2.3 vs surgical menopause 7.8 +/- 3.4 mM, p=0.213). CONCLUSION: IGF-1 was significantly lower in natural menopause as compared with surgical menopause, but no significant difference was found in IGFBP-3, Ost, and Dpd levels
Biomarkers* ; Carrier Proteins* ; Female ; Humans ; Insulin* ; Insulin-Like Growth Factor Binding Protein 3 ; Insulin-Like Growth Factor Binding Proteins* ; Insulin-Like Growth Factor I ; Menopause* ; Osteocalcin* ; Plasma ; Radioimmunoassay

OBJECTIVES: Early diagnosis of intrauterine growth retardation is important to ensure optimal monitoring and delivery with the introduction of real-time and Doppler ultrasound systems, a noninvasive method of measuring human fetal blood flow has become available. The aim of this study is to compare blood flow velocity waveforms at the fetal descending aorta and umbilical artery in normal and in patients with pregnancy induced hypertension. METHODS: Using a combination of linear array real-time and pulsed Doppler ultrasound, blood flow velocity measurements were carried out at the fetal descending aorta and umbilical artery in 35 normal pregnancies and 18 cases of pregnancy induced hypertensive patients. RESULTS: The mean systolic/diastolic ratio of umbilical artery and aorta was significantly higher in PIH patients than in normal pregnancies(3.8 +/- 0.81 versus 2.97 +/- 0.52, p<0.05) and to predict perinatal morbidity, umbilical velocimetry is more sensitive than that of descending thoracic aorta. CONCLUSION: This study suggests that umbilical artery velocimetry could be used as a marker to predict adverse perinatal outcome.
Aorta ; Aorta, Thoracic* ; Blood Flow Velocity ; Early Diagnosis ; Female ; Fetal Blood ; Fetal Growth Retardation ; Humans ; Hypertension, Pregnancy-Induced ; Pregnancy ; Rheology* ; Ultrasonography ; Umbilical Arteries

To identify significant prognostic factors in patients undergoing simple hysterectomy in the presence of invasive cervical cancer, the records of 45 patients who had taken such a procedure between 1993 and 1997 were reviewed. Overall relapse-free survival and 5-year survival rates were 91.1 and 92.1%, respectively. Factors found to be significantly related to survival were the retrospectively determined stage(p=0.0000), the presence of residual disease(p=0.0001), and cell type(p=0.0000). By multivariate analysis, factor emerging as significantly detrimental to survival was the cell type. The presence of residual disease was a marginally significant factor(p=0.067). The expectations for survival of patients with residual tumor mass and/or with adenocarcinoma after simple hysterectomy appear to be markedly worse than those with others, so radical reoperation should be considered in those patients.
Adenocarcinoma ; Humans ; Hysterectomy* ; Multivariate Analysis ; Neoplasm, Residual ; Reoperation ; Retrospective Studies ; Survival Rate ; Uterine Cervical Neoplasms*

OBJECTIVE: The purpose of this article is to report mixed germ cell tumor, which revealed changes compatible with early transformation of dysgerminoma to endodermal sinus tumor(EST) through histogenetic considerations and immunohistochemical stains. METHODS: Ovarian germ cell tumors were reviewed from files of Dept. Ob/Gyn. Seoul Paik Hospital fiom 1992.1 to 1996.12. Total of 5 cases include 4 pure dysgerminoma and 1 mixed germ cell tumars. All tissues were fixed in 10% neutral buffered formalin and embedded in paraffin and reviewed by two pathologists with immunohistochemical staining for cytokeratin, vimentin, AFP, PCNA, p53 & bc1-2. RESULTS: Grossly, the areas of transformation were located at the middle of the mixed tumor. The outer layer of the tumor mass was filled with typical pure dysgerminoma. They were characterised as the presence of microcysts and small glandular structures in hematoxylin-eosin(H-E) stains with positive stain for vimentin, except the tissue of the EST. The cells in the intermediate layer were characterised as the mixed form of dysgerminomatous and EST structures in H-E stains. AFP in the dysgerminomatous cells in intermediate layer and EST were stained, but not in outer layer. CONCLUSION: Dysgerminoma may possess the ability to transform to EST. There might be intermediate stage between dysgerminoma and EST, and Immunohistochemical staining for AFP, cytokeratin, vimentin, PCNA also can be used for prognosis of germ cell tumor.
Coloring Agents ; Dysgerminoma* ; Endoderm ; Endodermal Sinus Tumor* ; Formaldehyde ; Germ Cells ; Keratins ; Neoplasms, Germ Cell and Embryonal ; Paraffin ; Prognosis ; Proliferating Cell Nuclear Antigen ; Seoul ; Vimentin ; Yolk Sac*

No abstract available.
Arteries*

No abstract available.
Osteoarthritis*

Contusions ; Facial Bones ; Facial Nerve ; Facial Nerve Injuries ; Facial Paralysis ; Humans ; Incidence ; Lacerations ; Orbit ; Salivary Glands ; Skin ; Soft Tissue Injuries ; Wounds and Injuries

CT is the most accurate and reliable method for the diagnosis of intracerebral and intraventricularhemorrhage. The precise anatomic extent of the hematoma, associated cerebral edema, ventricular deformity anddisplacement, and hydrocephalus are all readily assessed. Aside from head trauma, the principal cause ofintracerbral hematoma is hypertensive vascular disease. Although hematomas from various causes may present similarCT appearances frequetnly the correct etiology may be suggested by considereation of patient's age, clinicalhistory, and the location of the hematoma. The analytical study was performed in 180 cases of intracerebralhamorrhages by CT from Oct. 1981 to Jan. 1983. The results were as follows; 1. The most prevalent age group was6th decade(37.2%) Male was prevalent to female at the ration of 1.6 to 1. 2. The most common symptom and sign wasmental distrubance (48.7%), motor weakness(23%), headache(10.6%), nausea and vomiting (9.8%). 3. The causes ofhemorrhage were hypertension (53.9%), head trauma (30.6%), aneurysm(6.1%) and A-V malformation (7.2%). 4. Thefrequent locations of hemorrhage were basal ganglia and thalamus(40.4%), lobes(35%), ventricles(21.8%). 5. Thedistribution of hemorrhage was intracerebral hemorrhage(65.6%), intracerebral and intraventricularhemorrhage(30.3%), intraventricular hemorrhage(4.4%).
Basal Ganglia ; Brain Edema ; Cerebral Hemorrhage ; Congenital Abnormalities ; Craniocerebral Trauma ; Diagnosis ; Female ; Hematoma ; Hemorrhage ; Humans ; Hydrocephalus ; Hypertension ; Male ; Methods ; Nausea ; Vascular Diseases ; Vomiting

No abstract available.
Mucocutaneous Lymph Node Syndrome*

PURPOSE: This study was undertaker in order to develop and characterize a new murine renal cell carcinoma(RCC) model which may be closely analogous to the human RCC and which may serve as a basis for the evaluation of new therapeutic modalities. MATERIALS AND METHODS: The tumor being investigated, Rag cell line, arose spont- aneously as a renal adenocarcinoma in an inbred Balb/c mouse. Tumor cells were injected into subrenal capsule and injected intravenously and intraperitoneally to induce tumors. Among the orthotopically inoculated animals, some were performed a nephrectomy to mimic the situation mostly often encountered in the human. RESULTS: 1 Tumors were transferred to all animals where inoculated into subrenal capsule. 2. The growth rates of tumor-bearing mice were retarded compared to control mice. 3. Tumors grew exponentially when inoculated into subrenal capsule. The doubling time of tumor was approximately 13 days. 4. Spontaneous lung metastasis could be better induced in the subrenal capsule model(80%). Higher rate of lung metastasis was obtained by intravenous inoculation of tumor cells(85.7%). 5. After nephrectomy performed on 14 days following subrenal capsular Inoculation of tumor cells, lung metastasis developed spontaneously in 80% of cases. CONCLUSIONS: The behavior of Rag tumor following subrenal capsular inoculation mimics that of human RCC from the viewpoint of the formation of primary tumor mass on the kidney followed by the development of spontaneous metastases. This model can be used for the evaluation of the therapeutic erects both on the primary tumor as well as on the metastatic disease.
Adenocarcinoma ; Animals* ; Carcinoma, Renal Cell* ; Cell Line ; Humans ; Kidney ; Lung ; Mice ; Models, Animal* ; Neoplasm Metastasis ; Nephrectomy