1.Immunohistochemical Study of the Expression of the p53 Protein in Primary Lung Cancer.
Sang Yong LEE ; Jin Sook JEONG ; Sook Hee HONG
Korean Journal of Pathology 1996;30(3):218-227
An immunohistochemical stain for p53 tumor suppressor gene product was performed in 59 primary lung cancers to study the relation between its expression and type of the tumor, degree of tumor differentiation,clinical stage and smoking. The results were as follows: 1. The expression of mutant p53 protein was noted in 28 of 59 cases(47.5%) of primary lung cancers. The p53 protein was expressed in 21 of 35(60%) squamous cell carcinomas, in 6 of 21(28.6%) adenocarcinomas, and 1 of 1(100%) small cell carcinoma. There was a significant difference in expression of p53 among the different histologic types of lung cancer(p<0.05). 2. The incidence of p53 protein expression did not correlate with the degree of tumor cell differentiation or the clinical stage of lung carcinoma(p>0.05). 3. The incidence of p53 protein expression was higher in smokers(current: 75%, former: 46.2%) than in non-smokers(5.6%) and was increased in direct proportion to the pack years. There was a statistically significant correlation between p53 expression and smoking(p<0.05). The mutation of p53 gene may often be an early event in the development of lung cancer and it is suggested that the smoking known as a risk factor for the development of the lung cancer may be associated with the transformation of p53 tumor suppressor gene into mutant p53 gene or oncogene.
Incidence
;
Risk Factors
;
Genes, Tumor Suppressor
;
Lung Neoplasms
2.Gastrointestinal leiomyosarcoma.
Yong Il PARK ; Kwan Hee HONG ; Sang Hyo KIM
Journal of the Korean Cancer Association 1993;25(4):478-487
No abstract available.
Leiomyosarcoma*
3.Avulsion of the Tibial Attachment of the Posterior Cruciate Ligament of the Knee Joint (Seven Cases Report)
Sang Won PARK ; Chang Yong HUR ; Hong Keun LEE
The Journal of the Korean Orthopaedic Association 1988;23(6):1522-1528
The posterior cruciate ligament plays as basic stabilizer of the knee. Therefore the knee becomes unstable when tibial insertion of the posterior cruciate ligament is avulsed. The diagnosis may be delsyed or missed because of surgeon's 1sck of awareness or rare condition. The authors treated seven cases of avulsion fracture of posterior cruciate ligsment at the tibial attachment ares ranged from ten to thirty-two years. There were five male and two female. The results were as follows : 1. The cause of all seven cases injury was traffic accident. 2. The physical findings were seven positive posterior drawer test, seven cases of abrasion or laceration over the anterior proximal tibial surface and antero-medial surfsce of the knee joint. 3. The associated injury was comminuted fracture of the tibia and femur (1 case), rupture of collateral ligsment and comminuted fracture of the tibia (1 case) and zygomatic fracture (1 case). 4. The treatment methods were four cancellous fixation, one K-wire fixation after epiphyseal plate fusion but each one pull out wire and dexon suture before epiphyseal plate fusion. 5. The motion of knee joint was within normal limit and no instsbility was inspected at the three months after reduction.
Accidents, Traffic
;
Diagnosis
;
Female
;
Femur
;
Fractures, Comminuted
;
Growth Plate
;
Humans
;
Knee Joint
;
Knee
;
Lacerations
;
Male
;
Posterior Cruciate Ligament
;
Rupture
;
Sutures
;
Tibia
;
Zygomatic Fractures
4.A Case of Clear Cell Sarcoma in Left Foot.
Young Chul KYE ; Yong Sang KIM ; Seung Min HONG ; Yong Woo CINN ; Soo Nam KIM
Korean Journal of Dermatology 1983;21(3):339-343
Clear cell sarcoma of tendon and aponeuroses is slow growing and painless. It occur chiefIy in young adults, predominates in women and is most common in the region of the foot and knee. It is intimately bound to tendons or aponeuroses and is composed of srnall nest or aggregates of round or fusiform, pale staining cells showing prominent nucleoli. And it is tend to recur and to resuIt in eventual development of metastatic growth after a protracted clinical ccurs. Herein, we report a case of clear cell sarcorna of tendon anu aponeuross of metatarsophalangeal joint area between 2nd and 3rd light of left foot. The patient, 50-year-old female had a slow groving, asymptomatic, slightly eevated, emooth surfaced and normal skin colored mass for 2 years. Histopatholcigic tindings in dermis revealed nests of atypical polygonal or monotonous cells. Each cell had vesicular or hyperchrornatic nucleus with prominent nucleoli, occcasionally mitotic figure and abundant eosinophilic cytoplasm. For. treatment, transmetatarsal amputation was done.
Amputation
;
Cytoplasm
;
Dermis
;
Eosinophils
;
Female
;
Foot*
;
Humans
;
Knee
;
Metatarsophalangeal Joint
;
Middle Aged
;
Sarcoma, Clear Cell*
;
Skin
;
Tendons
;
Young Adult
5.Clinical Significance of Bifrontotemporal Decompressive Craniectomy in the Treatment of Severe Refractory Posttraumatic Brain Swelling.
Hyung Shik SHIN ; Jin Yong KIM ; Tae Hong KIM ; Yong Soon HWANG ; Sang Jin KIM ; Sang Keun PARK
Journal of Korean Neurosurgical Society 2000;29(9):1179-1183
No abstract available.
Brain Edema*
;
Brain*
;
Decompressive Craniectomy*
6.Percutaneous transluminal balloon valvuloplasty for congenital pulmonary valvular stenosis.
Sung Min CHOI ; Gi Hong KIM ; Sang Bum LEE ; Doo Hong AHN ; Yong Joo KIM
Journal of the Korean Pediatric Society 1991;34(3):311-316
No abstract available.
Balloon Valvuloplasty*
;
Constriction, Pathologic*
7.Characteristics of Detrusor Overactivity Induced by Intravesical Instillation of Adenosine 5'-Triphosphate.
Sang Jin KIM ; Hong Sang MON ; Hong Yong CHOI ; Yong Tae KIM
Korean Journal of Urology 2008;49(5):424-431
PURPOSE: The bladder urothelium releases adenosine 5'-triphosphate(ATP) with mechanical stretch, which increases in a pathologic state such as a neurogenic bladder. We investigated the characteristics of detrusor overactivity induced by the intravesical instillation of ATP. MATERIALS AN METHODS: Under urethane anesthesia, cystometry was performed on female Sprague-Dawley rats. After pretreatment with protamine sulfate(PS, 10mg/ml), ATP(60mM, pH 6.0) was continuously infused intravesically. The effects of intravenous injection of pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid(PPADS) on ATP-induced detrusor overactivity were studied. Changes in cystometric parameters including parameters of each voiding phase, including bladder pressure increase rate(slope; Ph1slope), maximal bladder pressure(Ph1MBP, Ph2MBP, Ph3MBP), mean bladder pressure(Ph2meanBP) and variation of intraluminal pressure high-frequency oscillations(IPHFOs) were analysed. RESULTS: With the intravesical instillation of ATP after PS pretreatment, the intercontraction interval(ICI) decreased significantly(544.2+/-167.2s vs 222.3+/-170.8s, p=0.001), maximal voiding pressure(MVP) decreased significantly(31.3+/-4.7cmH2O vs 25+/-2.9cmH2O, p=0.001), and pressure threshold (PT) decreased significantly(4.0+/-1.3cmH2O vs 1.4+/-0.8cmH2O, p=0.001). Changes in the ICI, MVP & PT induced by intravesical instillation of ATP were reversed by intravenous injection of PPADS. Ph1slope, Ph1MBP, Ph2MBP, Ph2meanBP and Ph3MBP were decreased, but IPHFOs were not affected by intravesical application of ATP. Conclusions: Intravesical instillation of ATP in female rats induced detrusor overactivity, which may be mediated by acting on the urine storage phase.
Female
;
Humans
;
Rats
;
Animals
8.Characteristics of Detrusor Overactivity Induced by Intravesical Instillation of Adenosine 5'-Triphosphate.
Sang Jin KIM ; Hong Sang MON ; Hong Yong CHOI ; Yong Tae KIM
Korean Journal of Urology 2008;49(5):424-431
PURPOSE: The bladder urothelium releases adenosine 5'-triphosphate(ATP) with mechanical stretch, which increases in a pathologic state such as a neurogenic bladder. We investigated the characteristics of detrusor overactivity induced by the intravesical instillation of ATP. MATERIALS AN METHODS: Under urethane anesthesia, cystometry was performed on female Sprague-Dawley rats. After pretreatment with protamine sulfate(PS, 10mg/ml), ATP(60mM, pH 6.0) was continuously infused intravesically. The effects of intravenous injection of pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid(PPADS) on ATP-induced detrusor overactivity were studied. Changes in cystometric parameters including parameters of each voiding phase, including bladder pressure increase rate(slope; Ph1slope), maximal bladder pressure(Ph1MBP, Ph2MBP, Ph3MBP), mean bladder pressure(Ph2meanBP) and variation of intraluminal pressure high-frequency oscillations(IPHFOs) were analysed. RESULTS: With the intravesical instillation of ATP after PS pretreatment, the intercontraction interval(ICI) decreased significantly(544.2+/-167.2s vs 222.3+/-170.8s, p=0.001), maximal voiding pressure(MVP) decreased significantly(31.3+/-4.7cmH2O vs 25+/-2.9cmH2O, p=0.001), and pressure threshold (PT) decreased significantly(4.0+/-1.3cmH2O vs 1.4+/-0.8cmH2O, p=0.001). Changes in the ICI, MVP & PT induced by intravesical instillation of ATP were reversed by intravenous injection of PPADS. Ph1slope, Ph1MBP, Ph2MBP, Ph2meanBP and Ph3MBP were decreased, but IPHFOs were not affected by intravesical application of ATP. Conclusions: Intravesical instillation of ATP in female rats induced detrusor overactivity, which may be mediated by acting on the urine storage phase.
Female
;
Humans
;
Rats
;
Animals
9.Malignant Rhabdoid Tumor of the Kidney in an Adult: A case report.
Sang Yong LEE ; Dae Cheol KIM ; Seo Hee RHA ; Sook Hee HONG
Korean Journal of Pathology 1996;30(6):539-543
Malignant rhabdoid tumor is a distinct renal tumor in pediatric age group and extremely rare in adults. It was originally described as a rhabdomyosarcomatoid variant of Wilms' tumor. But subsequent studies failed to confirm myogenous differentiation, so the rhabdoid tumor is now considered to be a distinct and unique disease type of highly malignant renal tumor, histogenetically unrelated to Wilms' tumor. However the histogenesis have not been clearly defined until now. We report a case of malignant rhabdoid tumor of the kidney in a 34-year-old man who represented with a left abdominal mass. Grossly, a large mass occupying most of the left kidney except for a part of upper pole was invading beyond renal capsule and the perirenal soft tissue. It measured 18x14 cm in dimension and was soft, lobulated and yellowish gray with large areas of hemorrhage and necroses. Microscopically, the tumor mass was composed of sheets of round or polygonal neoplastic cells growing in a solid pattern. These tumor cells were medium to large in size with ample cytoplasm containing recognizable eosinophilic inclusion and had an eccentrically located, large nucleus with one or a few prominent nucleoli. Mitotic figures were frequently observed. Ultrastructurally, the tumor cells contained whorled filamentous inclusions corresponding to vimentin, epithelial membrane antigen and cytokeratin in immunostaining.
Adult
;
Male
;
Female
;
Humans
10.Effects of Reactivation of Latent Epstein-Barr Virus Using Polymerase Chain Reaction on Acute Hepatitis A in Children.
Seung Hyon BAEK ; Sang Yong KIM ; Hong KOH
Korean Journal of Pediatric Gastroenterology and Nutrition 2011;14(1):59-66
PURPOSE: We previously reported that concurrent reactivation of latent Epstein-Barr virus (EBV) in children with hepatitis A virus (HAV) infection is common and EBV reactivation with HAV infection adversely affects the clinical features of hepatitis. However, the incidence of concurrent reactivation was not accurate because the detection of EBV reactivation was based on serologic methods. Therefore, we studied the effects of polymerase chain reaction (PCR)-proven EBV reactivation, thus a more precise concurrence, on acute HAV infection in children. METHODS: PCR were conducted in 34 patients, who had enrolled previous study and diagnosed with acute HAV infection between January 2008 and June 2010. Their medical records were reviewed. RESULTS: Among 34 patients with acute HAV infection, 12 patients (35.3%) had EBV reactivation which was proven using serologic and molecular biologic techniques. There were significant differences in the peak levels of AST and ALT between the reactivated and non-reactivated groups (p=0.001 and p<0.001, respectively). The duration of full recovery from hepatitis was more prolonged in the reactivated group (p<0.001). Clinical parameters, such as serum protein (p<0.001) and albumin concentrations (p<0.001), atypical lymphocyte count (p=0.001), prothrombin time-international normalized ratio (PT-INR, p<0.001), and splenomegaly (p<0.001), showed significant differences. The clinical features in the reactivated sub-group >10 years of age revealed more liver dysfunction compared to the non-reactivated sub-group. A comparison with a previous study was performed. CONCLUSION: PCR-proven reactivation of latent EBV in children with HAV infection is common and EBV reactivation with HAV infection adversely affects the clinical features of hepatitis, especially in older children.
Child
;
Hepatitis
;
Hepatitis A
;
Hepatitis A virus
;
Herpesvirus 4, Human
;
Humans
;
Incidence
;
Liver Diseases
;
Lymphocyte Count
;
Medical Records
;
Polymerase Chain Reaction
;
Prothrombin
;
Splenomegaly