PURPOSE: A varicocele is the most common correctable cause of infertility in men. Conventional techniques of varicocele repair are associated with substantial risks of hydrocele formation, varicoele persistence and recurrence. The inguinal approach with classic Palomo technique was used to be simplified the procedure and to get the same good results with the Palomo technique. MATERIALS AND METHODS: From March 1990 to March 1997, we experienced surgical corrections of 54 patients with varicocele(A mean age 20.3 years) The most of patients were left-sided(96.3%). Until March 1996, surgical correction with Palomo(6 patients) and modified Palomo(13 patients) technique by retroperitoneal approach and Ivanissevich techrique(20 patients) by inguinal approach have been performed, and since April 1996, Palomo technique(15 patients) with inguinal approach has been performed, in which the entire vascular pedicle is ligated superior to the entrance of the was deferens through the inguinal incision. RESULTS: The postoperative recurrences in the modified Palomo technique occurred In two of the 13 patients(15%) and in the Ivanissevich technique in three of the 20 patients(15%). But there were no recurrences In the retroperitoneal Palomo and modified inguinal Palomo techniques. The modified inguinal Palomo technique was completed within 45.3minutes in mean duration, but the standard retroperitoneal Palomo technique within 55.2minutes, modified Palomo technique within 57.2minutes and Ivanissevich technique within 51.4minutes. There was no varicocele recurrence, hydrocele and atrophy of testis in modified inguinal Palomo techniques. CONCLUSIONS: The modified inguinal Palomo technique was easily approachable and relatively fast in our experience and had no recurrence.
Atrophy ; Humans ; Infertility ; Male ; Recurrence ; Testis ; Varicocele*

We report a case of X-linked ichthyosis in a 19 year-old male patient who has been covered with brown to black colored thick scales on the lateral aspect of chest, upper abdomen and inner aspect of both extremities since one month at, birth. Histopathologic findings showed hyperkeratosis and papillomatosis with normal granular cell layers in the epidermis. On electron microscopy, multilayered keratins with increased melanosomes in the stratum corneum were noted. In his family, his cousin is also affected by the same disease.
Abdomen ; Epidermis ; Extremities ; Humans ; Ichthyosis* ; Male ; Melanosomes ; Microscopy, Electron ; Papilloma ; Parturition ; Thorax ; Weights and Measures ; Young Adult

Psoriasis and eczematous dermatitis are two major different inflarnmtory dermatitis but differential diagnosis is sometimes difficult by histologic patterns. The object of this study is to find out whether there are any differences in the expressions of proliferation related pntein between psoriasis and eczematous dermatitis by chronological evaluation on the proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGFR). The detections of PCNA and EGFR were done by immunohistoc.ienical methods(alkaline phosphatase anti-alkaline phosphatase method with new fuchsin substrated usir g respective polyclonal antibod ies in the paraffin embedded tissue from psoriasis(21 cases) and eczomtous dermatitis(26 cases). The labelling indeces of PCNA were 2.4+0.9% in normal. Indece; were 27.3+2.9% in acute, 20.7+ 3.7% in chronic psoriasis, while 12.4+5.6% in acute and 21.8% 5.0% in chronic eczematous dermtitis. The expressions of EGFR were very weak in normal, and increased in acute psoriasis and chronic eczematous dermatitiy. Our immunohistochemical results of PCNA and EGFR suggest that activated proliferation is rather pronounced in acute psoriasis and chronic eczemat.ous dermatitis, thouh proliferative activity is more marked in psoriasis.
Dermatitis ; Diagnosis, Differential ; Eczema* ; Epidermal Growth Factor* ; Paraffin ; Proliferating Cell Nuclear Antigen* ; Psoriasis ; Receptor, Epidermal Growth Factor* ; Rosaniline Dyes

Backgroud : The number of proliferating cell populations in the hair is follicles is closely related to the regulation of hair growth. Destruction of hair germ cells and the loss of proliferating cells have been suggested to be of major pathogenetic significance in alopecia areata OBJECTIVE: The purpose of this study is to compare the growth frrections in proliferating cells of normal hair follicles with those in alopecia. METHODS: An immunohiatochemical study was done to detect the proliferating cells in hair follicles using a monoclonal antibody against proliferating cell nuclear antigen(PCNA) in the scalp biopsy of an alopecia patient on the peraffin embedded sections. RESULTS: A significant decrease of the labelling indeces of PCNA were observed in the hair follicles of alopecia compared with normal condition. But we could not find significant differences of labelling index in the clinical types of alopecia, responses to treatment, anc systemic immunologic state. CONCLUSIONS : Whole the above results confirmed that significant decreases of proliferating cells in the hair follicle could explain the part of the pathogenetic mechanism in alopecia, its direct cause which inhibit the proliferation of cells is not clear.
Alopecia Areata ; Alopecia* ; Biopsy ; Germ Cells ; Hair ; Hair Follicle ; Humans ; Proliferating Cell Nuclear Antigen* ; Scalp

BACKGROUND: Glutathione S-transferase(GST) is a family of isoenzymes that play an important role in protecting cells from cytotoxic and carcinogenic agents. Strong activities of GST-Pi in the epithelial tissues was observed in the upper layer of skin, gastrointestinal tract and placenta which have been exposed to exogenous chemicals. OBJECTIVE: This study was done to observe the distribution pattern of GST-Pi in normal, acute and chronic psoriasis or eczematous dermatitis, using paraffin-embedded human skin tissues. METHODS: Twenty-one psoriatic and twenty-six eczematous dermatitis specimens were observed by immunohistochemical staining using an anti-rabbit GST-Pi polyclonal antibody. RESULTS: Stainining reaction for the GST is weakly to moderately stained in the normal epidermis. In the acute stage, upper layer shows weak and moderate staining in the lower epidermis of the psoriasis and eczematous dermatitis but in the chronic stage GST-Pi are noted strongly expression in upper epidermis. CONCLUSION: Immunohistochemical staining for the GST-Pi reveals a more abundant distribution in the chronic stage rather than in the acute stage of psoriasis and eczema tous dermatitis, showing no disease specificity. Therefore it is suggested that the detoxifying capacity decreases in the acute stage of above dermatosis.
Dermatitis ; Eczema* ; Epidermis ; Gastrointestinal Tract ; Glutathione Transferase* ; Glutathione* ; Humans ; Isoenzymes ; Placenta ; Psoriasis* ; Sensitivity and Specificity ; Skin ; Skin Diseases

BACKGROUND: The effects of intralesional recombinant alpha-2 interferon(IFN) in the treatment of basal cell carcinoma(BCC) and actinic keratosis(AK) would be of value in selected patients. OBJECTIVE: Our purpose is to evaluate the differences of cellular immune reactions between the responded and the unresponded cases treated with IFN. METHODS: We treated five patients with BCC and two patients with AK with the intralesional injection of recombinant alpha-2 IFN. We performed immunohistochemical stainings with paraffin-embedded specimens from the pretreated and posttreated skin lesions. RESULTS: Four patients(three with BCC and one with AK) were healed and three patients showed improvement after treatment. In immunohistochemical stainings, there was an increased number of T cells in the dermal infiltrate of the responded cases but not in the unresponded cases. CONCLUSION: Intralesional IFN may induce T cell-mediated immune response at the site of the tumor by immune modulation.
Actins* ; Carcinoma, Basal Cell* ; Humans ; Injections, Intralesional* ; Interferons* ; Keratosis, Actinic* ; Skin ; T-Lymphocytes

A 7-year-old girl had a 7 × 6cm sized dark red colored tumor on the left elbow and several erythematous macules on the face, right upper arm, and both thighs. Her general health was good and all laboratory findings were within normal limit. Histopathologic examination revealed an infiltration of atypical mononuclear cells in the dermis and subcutis. L26 and leukocyte common antigen were positively stained in an immunohistochemical study. According to clinical, histological and immunohistochemical findings, we diagnosed the disease as primary cutaneous B cell lymphoma. The patient's skin lesions markedly improved after a surgical excision and chemotherapy.
Antigens, CD45 ; Arm ; Child ; Dermis ; Drug Therapy ; Elbow ; Female ; Humans ; Lymphoma, B-Cell* ; Skin ; Thigh

We report 6 cases of sporotricosis including 3 cases of lymphocutaneous type and 3 cases of fixed cutaneous type. There were 3 males and 3 females patients in the age between 5 to 63 year-old age. Clinically, histopathologically and mycologically, we diagnosed the cases as the sporotrichosis. And then case 1 and 2 were treated with potassium iodide for 9 weeks and 15 weeks duration. Case 3, 4, 5 and 6 were treated with itraconazole for 10-14 weeks duration. All patients were almost healed without recurrence.
Female ; Humans ; Itraconazole* ; Male ; Potassium Iodide* ; Potassium* ; Recurrence ; Sporotrichosis*

No abstract available.
Epidermis* ; Skin Diseases* ; Skin*

No abstract available.
Estrogens* ; Humans ; Receptors, Estrogen* ; Thyroid Diseases* ; Thyroid Gland*