1.A clinical study of colorectal cancer.
Young Dae KWON ; Yong Oon YOO ; Kwang Duck HUR
Journal of the Korean Surgical Society 1993;44(2):266-272
No abstract available.
Colorectal Neoplasms*
2.Microcystic Adenoma of Pancreas: Case report.
Ki Ho PARK ; Yang Il KIM ; Yong Oon YOO ; Sung Hwan PARK ; Han Il LEE ; Dae Hyun JOO
Journal of the Korean Surgical Society 1997;53(3):456-459
Microcystic adenoma, also known a glycogen rich or serous cystadenoma is very rare and usually presents grossly a large multiloculated mass, and the individual cystic cavities being small and filled with a clear(serous) fluid. The cut surface is spongy in appearance. Microscopically, cysts are composed of multiple small cysts lined by small, flat or cuboidal cells containing abundant glycogen but only an insignificant amount of mucin. The microcystic cystadenoma is benign, but mucinous cystadenoma is potentially malignant,so the two cysts should be differentiated, and should never be treated by-pass sugery in the case of mucinous cystadenoma. A 43-year-old female was admitted to this hospital with the palpable epigastric mass, postprandial nausea and weight loss for the preceeding 2 years, and increase in size in the past recent 8 months. Upper G.I series and ultrasonographic studies revealed a huge mass in the pancreatic head portion. Exploratory laparotomy was performed, which disclosed a round adult fist sized multicystic mass in the pancreatic head. Pancreaticoduodenectomy was performed. In gross specimen examination, the mass was 9x7.5x7 cm in size, the outer surface was smooth and grayish white, the cut surface was sponge- like with multiple small cysts. The content of cysts was serous fluid. Microscopically, the cystic mass was composed of small cysts, in which the lining of the cell shows flat and mild secretory activity. There was no malignant evidence. The patient was discharged uneventfully on the 22nd postoperative days.
Adenoma*
;
Adult
;
Cystadenoma
;
Cystadenoma, Mucinous
;
Cystadenoma, Serous
;
Female
;
Glycogen
;
Head
;
Humans
;
Laparotomy
;
Mucins
;
Nausea
;
Pancreas*
;
Pancreaticoduodenectomy
;
Weight Loss
3.Comparative Nerve Distribution of the Pylorus in Infantile Hypertrophic Pyloric Stenosis.
Gang Do KIM ; Dae Hyun JOO ; Yong Oon YOO ; Sung Hwan PARK ; Ki Ho PARK ; Jae Bok PARK
Journal of the Korean Association of Pediatric Surgeons 2002;8(1):23-27
Infantile hypertrophic pyloric stenosis (IHPS) a common childhood disorders characterized by nonbilious projectile vomiting, an olive shaped mass in the right upper quadrant of the abdomen and visible gastric peristaltic wave in the upper abdomen. Its etiology and pathogenesis are not clear but abnormal nerve distribution of the pylorus has been postulated2-6. We performed immunocytochemical staning to the pyloric muscle from 10 IHPS and 3 controls patients, utilizing specific monoclonal antibody to NCAM(neural cell adhesion molecule). In IHPS patients, the number of NCAM protein immunoreactive nerve fibers were less than that in normal subjects. Auerbach myenteric plexuse was well developed and interbundle nerve plexuse was present but nerve fibers supplying individual muscle cells in smooth muscle bundles were poorly developed. These results indicate reduction of innervation in smooth muscles in IHPS patients that possibly contributes to the pathogenesis of IHPS.
Abdomen
;
Cell Adhesion
;
Humans
;
Muscle Cells
;
Muscle, Smooth
;
Myenteric Plexus
;
Nerve Fibers
;
Neural Cell Adhesion Molecules
;
Olea
;
Pyloric Stenosis, Hypertrophic*
;
Pylorus*
;
Vomiting
4.Clinical Significance of Lymphocyte Subpopulations in Peripheral Blood from Gastric Cancer Patients.
Seok Hun SONG ; Han Il LEE ; Ki Hyuk PARK ; Dae Hyun JOO ; Sung Hwan PARK ; Yong Oon YOO ; Ki Ho PARK ; Sang Kyeong KIM
Journal of the Korean Surgical Society 1998;55(Suppl):997-1003
BACKGROUND : There are plenty of documented observations of gastric cancer patients having suppressed cellular immunity, and this immunity may be correlated to recurrence. We studied the changes in the peripheral T-lymphocyte subpopulations in gastric cancer patients and their predictive roles for recurrence. METHODS : Lymphocyte subpopulations in peripheral blood from thirty-eight gastric cancer patients who were operated on at Taegu Catholic Medical Center from September 1995 to February 1997 were measured by 3-color direct immunofluorescence analysis with a Coulter S-plus IV automatic counter. RESULTS : CD4 significantly increased with tumor size and depth of invasion although other immune parameters, such as CD8, CD19, the CD4/CD8 ratio, and total lymphocyte count did not changed. In the patients with lymph-node metastasis, increases in CD3 and CD4 and a decrease in CD19 were observed. CD19 and the B lymphocyte count also decreased in advanced gastric cancer patients. However, T-lymphocytes subpopulations did not significantly change with stage. There were significant decreases in CD8 and in the T- & B-lymphocyte counts, without changes in CD4 and the CD4/CD8 ratio in the postoperative immune parameters.The preoperative values of the T- & B-lymphocyte counts and CD8 and CD19 were lower in patients who had recurrences during six months to two years of follow up, compared to recurrence-free patients. CONCLUSIONS : On the basis of these results, we found changes of T-lymphocyte subpopulations with size, depth of invasion, and regional lymph node metastasis, but not with stage. Postoperatively, there were significant decreases in the T- & B-lymphocyte counts. Suppressed immunity correlated with recurrence, and preoperative evaluation of peripheral T-cell subpopulations may be helpful for predict recurrence and for postoperative prognosis.
B-Lymphocytes
;
Daegu
;
Fluorescent Antibody Technique, Direct
;
Follow-Up Studies
;
Humans
;
Immunity, Cellular
;
Lymph Nodes
;
Lymphocyte Count
;
Lymphocyte Subsets*
;
Lymphocytes*
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
;
Stomach Neoplasms*
;
T-Lymphocytes
5.Clinical Significance of Cellular Fibronectin as a Tumor Marker in Gastric Cancer Patients.
Soon Jai JUNG ; Han Il LEE ; Ki Hyuk PARK ; Dai Hyun JOO ; Sung Hwan PARK ; Yong Oon YOO ; Ki Ho PARK ; Chang Ho JUN
Journal of the Korean Surgical Society 1998;55(Suppl):985-990
BACKGROUND : Fibronectins (FNs) are adhesive glycoproteins that have variable primary structures owing to cell type-specific splicing of the FN precursor mRNA. FNs can be classified as plasma (p-FN) and cellular (c-FN) types, and c-FN may play a role as a marker of malignancies. CEA and CA 125 have been reported as useful tumor markers, but FNs have not studied adequately in gastric cancers. METHODS : We evaluated the clinical significance of urinary and plasma c-FN in thirty-five patients who were operated on our department due to gastric cancer from January 1997 to August 1997. The c-FN level was determined by enzyme immunoassay using a FIBRONECTIN EIA kit (Takara Shuzo Co., Kyoto, Japan). RESULTS : The levels of urine c-FN in gastric cancer patients (215.6 470.2) were higher than those in the control groups (94.1 63.0 ng/mgCr) and also showed a tendency to increase with advancing of tumor growth. A higher rate of increased urine c-FN also was identified in patients with distant metastasis than in patients without distant metastasis (6/8 vs. 10/27, p=0.05). However, p-FN didn't showed any differences according to extent of tumor invasion and/or presence of distant metastasis. Other parameters, such as age, sex, preoperative tumor size, and depth of invasion, were not correlated with urine and plasma c-FN. CONCLUSIONS : Urine c-FN may be useful as a new tumor marker in gastric cancer and can be helpful in early detection of metastasis and peritoneal seeding, but further studies and follow up are needed for complete clinical application.
Adhesives
;
Biomarkers, Tumor
;
Fibronectins*
;
Glycoproteins
;
Humans
;
Immunoenzyme Techniques
;
Neoplasm Metastasis
;
Plasma
;
RNA, Messenger
;
Stomach Neoplasms*
6.Acute Occlusion of the Abdominal Aorta by Various Causes.
Soo Bum KWON ; Ki Hyuk PARK ; Soon Jae JUNG ; Dong Lak CHOI ; Dae Hyun JOO ; Han Il LEE ; Sung Hwan PARK ; Yong Oon YOO ; Ki Ho PARK
Journal of the Korean Society for Vascular Surgery 2003;19(2):190-193
We report various causes of acute abdominal aortic occlusion, a condition which is infrequent but usually ends catastrophically. The three cases are embolic occlusion by myxoma, thrombotic occlusion of aortic aneurysm, and thrombosis of an atherosclerotic aorta; the first two causes are very rare clinical presentations. All patients showed leg paralysis, pain, and severe ischemic symptoms. Diagnosis was done by emergent-CT (computed tomography) scan and surgery was performed urgently. Nevertheless, all patients died in the early postoperative period. As acute aortic occlusion is infrequent, its diagnosis may be delayed. The mortality rates remains high even with urgent surgical care.
Aorta
;
Aorta, Abdominal*
;
Aortic Aneurysm
;
Diagnosis
;
Humans
;
Leg
;
Mortality
;
Myxoma
;
Paralysis
;
Postoperative Period
;
Thrombosis
7.Clinical Analysis of 36 Appendectomies in Pregnant Women.
Chong Suk LEE ; Dae Hyun JOO ; Han Il LEE ; Sung Hwan PARK ; Yong Oon YOO ; Yang Il KIM ; Ki Ho PARK
Journal of the Korean Surgical Society 1997;53(3):408-414
Appendicitis is the most common acute abdominal condition that requires an operation during pregnancy. Variable clinical presentations in pregnant women make the diagnosis of acute appendicitis difficult, delay operative intervention, and cause many fetal or maternal complications. From January 1990 through December 1996, 36 appendectomies were performed on pregnant women at our hospital. This is a retrospective analysis of our cases compared to control group. 1. Thirty six pregnant women (0.1 %) from all labor cases during this period underwent appendectomies, representing 10.3 % of all appendectomies in women of childbearing age. 2. The age distribution was 21-25 (38.9 %), 26-30 (55.6 %) and 31-35 (5.5 %) years, which was similar to the age distribution of the non-pregnant group. 3. Acute appendicitis during pregnancy was most common in the spring. 4. No significant difference in the occurrences of various symptoms between the pregnant and the non-pregnant groups was observed. 5. The pregnant patients visited our hospital earlier, but underwent operations later, than the non-pregnant women. (p < 0.05) 6. An increase in the WBC count to above 15,000/mm3 was more common in the pregnant patients with appendicitis.(p < 0.05) 7. The appendix was normal in 22.2 % of the appendectomy cases during pregnancy; however, no significant difference in diagnostic accuracy was observed between pregnant and non-pregnant groups. (p > 0.05) 8. No significant differences between the pregnant and the non-pregnant groups were noticed in terms of operation time and types of anesthesia. (p > 0.05) 9. The wound infection rates were similar for the pregnant (16.7 %) and the non-pregnant (17.4 %)groups, but there were 3 fetal losses (8.3 %)from pregnant patients after their appendectomies. 10. The mean hospital stay was longer for the pregnant patients (7.6 days) than for the non-pregnant group (6.2 days).
Age Distribution
;
Anesthesia
;
Appendectomy*
;
Appendicitis
;
Appendix
;
Diagnosis
;
Female
;
Humans
;
Length of Stay
;
Pregnancy
;
Pregnant Women*
;
Retrospective Studies
;
Wound Infection
8.One Case of Mucin Hypersecreting Papillary Adenocarcinoma of the Left Intrahepatic Duct.
Dae Hyun JOO ; Yong Oon YOO ; Suk Hoon SONG ; Han Il LEE ; Ki Ho PARK ; Yang Il KIM ; Ho Gak KIM ; Jae Bok PARK
Korean Journal of Hepato-Biliary-Pancreatic Surgery 1997;1(2):179-184
A patient with mucin hypersecreting papillary adenocarcinoma of intrahepatic bile duct had jaundice and symptoms of cholangitis. Radiologic evaluations-ultrasonography and computerized tomographyrevealed passage disturbance of bile at the level of the distal common bile duct or ampulla of Vater. But, primary lesion was located at left intrahepatic duct proximal to the ductal dilatation. This peculiar phenomenon confused clinicians. A 59-year-old man was referred to our hospital for evaluation of recurrent cholangitis. Ultrasonogram, computerized tomogram and endoscopic retrograde cholangiography disclosed dilatation and amorphous filling defect extending from left intrahepatic bile duct to common bile duct suggesting choledochal cyst(type IVa). Preoperative endoscopic examination showed spillage of mucin through duodenal papilla. Abdominal exploration revealed mucin hypersecreting papillary adenocarcinoma of left intrahepatic duct and dilated distal common bile duct filled with tenacious mucin. Left hepatic lobectomy and Roux-en-Y hepaticojejunostomy were performed.
Adenocarcinoma
;
Adenocarcinoma, Papillary*
;
Ampulla of Vater
;
Bile
;
Bile Ducts, Intrahepatic
;
Cholangiography
;
Cholangitis
;
Common Bile Duct
;
Dilatation
;
Humans
;
Jaundice
;
Middle Aged
;
Mucins*
;
Ultrasonography
9.Growth and Metastasis of MCF-7 Breast Cancer Cells Grafted to huPBMC-SCID Mouse.
Sung Hwan PARK ; Dong Lak CHOI ; Ki Hyuk PARK ; Dae Hyun JOO ; Han Il LEE ; Yong Oon YOO ; Ki Ho PARK ; In Soo SUH
Journal of Korean Breast Cancer Society 2002;5(4):273-278
PURPOSE: The severe combined immunodeficient (SCID) mice which lack the functional T and B lymphocytes have been widely used for the research of various human diseases including AIDS, transplantation, autoimmune disease and cancer. The purpose of this study was to evaluate the huPBMC-SCID mouse as an animal model for human breast cancer research. METHODS: 5x10(7) human PBMC (peripheral blood mononuclear cell) were injected intraperitoneally in 18 SCID mice. After 24 hours, 2.5x10(6), 5x10(6) and 10x10(6) MCF-7 human breast cancer cells were innoculated subcutaneously in the right flank of each of the 3 groups of 6 huPBMC-SCID mice. RESULTS: 4 subcutaneous ecchymosis (2 perioral area, 2 scalp), 1 splenomegaly and 1 hepatic embolism were found during the 20 weeks after the injections. The growth of tumor xenograft was identified in 14 of the total 18 huPBMC-SCID mice, and the growth rate of the tumor was proportional to the number of the innoculated cancer cells. Distant metastases were found in the retroperitoneum, kidney, pelvic cavity, omentum, perisplenic area and regional lymph node in 50 % of mice, but not in the lung and liver at 20 weeks. CONCLUSION: In summary, the huPBMC-SCID mouse was expected to play an important roles as an animal model of human cancers including breast cancer.
Animals
;
Autoimmune Diseases
;
B-Lymphocytes
;
Breast Neoplasms*
;
Breast*
;
Ecchymosis
;
Embolism
;
Heterografts
;
Humans
;
Kidney
;
Liver
;
Lung
;
Lymph Nodes
;
Mice*
;
Mice, SCID
;
Models, Animal
;
Neoplasm Metastasis*
;
Omentum
;
Splenomegaly
;
Transplants*
10.Differential Diagnosis between Malignant and Benign Breast Diseases Using Localized Proton Magnetic Resonance.
Sung Hwan PARK ; Ki Ho PARK ; Han Il LEE ; Dae Hyun JOO ; Ki Hyuk PARK ; Yong Oon YOO ; Jong Ki KIM
Journal of Korean Breast Cancer Society 1998;1(1):1-5
Proton magnetic rcsonance spectroscopy (1H MRS) has demontrated its abilities to detect an increase of choline containing compounds (Cho) in various brain tumors and prostatic cancer tissues. Based on preclinical works done by other authors using multinuclei MRS, it is reasonable to assume malignant breast tumors will have elevated level of Cho compared to that of normal tissues and benign breast lesions. Several challenges must be met to obtain clinically useful 1H breast spectrum. Good water and fat suppression, Bo homogeneity are required to detect low level metabolic signals like choline if any. In this study, we investigated the clinical utility of 1H MRS with simultaneous suppression of water and fat signals, using breast imaging surface coil for evaluating breast cancer with small lesions. All studies were performed using a GE signa MRI unit (1.5 T, Ver 5.5) and 2-channel breast coil (GE). Water suppression was achieved by chemical selective saturation, and fat signal was attenuated using inversion recovery sequence. Spectroscopic data were acquired with PRESS sequence. Twenty-three patients, age 14-75, were examined. Eleven of these patients presented with invasive ductal carcinoma. The remaining patients presented with benign processes including fibroadenoma, fibrocystic change, galactocele, adenosis, ductal ectasia and dystrophic calcification. The size of lesions were variable (8-90 mm in diameter). Choline at 3.25 ppm was visible in the spectra of all cancer patients, while invisible in the spectra of all benign lesions except a lesion of dystrophic calcification. We concluded that in vivo detection of choline containing compounds in breast carcinomas using proton magnetic resonance spectroscopy demonstrated its potential as a noninvasive tool for differential diagnosis of malignant and benign breast lesions larger than 7 mm in diameter.
Brain Neoplasms
;
Breast Diseases*
;
Breast Neoplasms
;
Breast*
;
Carcinoma, Ductal
;
Choline
;
Diagnosis, Differential*
;
Dilatation, Pathologic
;
Fibroadenoma
;
Humans
;
Magnetic Resonance Imaging
;
Magnetic Resonance Spectroscopy
;
Prostatic Neoplasms
;
Protons*
;
Spectrum Analysis
;
Water