OBJECTIVE:To study the preparation and quality control methods of ribavirin and ephedrine nasal spray and observe its clinical therapeutic efficacy.METHODS:To determine the content of ribavirin and that of ephedrine hydrochloride by ultraviolet spectrophotometry and polarimetry respectively and observe the clinical therapeutic efficacy in 40 patients.RES_ULTS:The average recoveries of ribavirin and ephedrine hydrochloride were 100.05%(RSD=0.50%) and 100.10%(RSD=0.29%) respectively.Its effective rate in treating virus infections of upper respiratory tract was 97%.CONCLUSION:The preparation of ribavirin and ephedrine nasal sprays is reasonable in technology,stable in quality,feasible in quality control and reliable in therapeutic efficacy.It is worth popularizing the application of this preparation.

This article analysis the present situation of less than 35 years of Sun Yat-sen university youth scientific and technological personnel,they declare、undertake to support basic research based science fundation related cases,discusses the science foundation for their assistance and training problems,put forward youth scientific talents to suit the science funds development requirements to promote their development proposals

Endometrial Neoplasms ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; methods ; Lymph Nodes ; pathology ; Neoplasm Staging ; Ovarian Neoplasms ; pathology ; surgery ; Retroperitoneal Space

T helper 17 cells (Th17) are a novel subset of CD4+ T cells that undergo differentiation from naive CD4 T cells through the activation of a key nuclear transcription factor,retinoic-acid-receptor-related orphan receptor γt (RORγt),and in the presence of multiple cytokines,such as transforming growth factorβ1 (TGF-β1),interleukin6 (IL-6),as well as IL-23.Th17 cells induce their biological effect by secreting IL-17A and other cytokines.Research has demonstrated that Th17 cells have an intimate relationship with acute/chronic transplant reactions and that Th17 cell lineages have the possibility to become the new target for treating transplant rejections.Identification of Th17 cells also provides an additional strategy for inducing immune tolerance.

Probiotics modulate the biological functions (and even cell apoptosis) of intestinal epithelial cells,intestinal macrophages,intestinal dendritic cells,and T cells via cell signaling pathways including nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.Peroxisome proliferator-activated receptor γ (PPARγ) and heat shock protein (hsp) are targets for probiotics or their products.

Objective:To evaluate the characteristics of fusion using biomimetic n-HA/PA66 interbody cage with rhBMP-2 and discuss the feasibility of it.Methods:Thirty adult female goats underwent C_(3-4) discectomy and interverbral fusion performed with nHA/PA66 interbody cage without rhBMP-2(n=10).nHA/PA66 interbody cage with rhBMP-2(n=10),autogenous iliac crest bone graft(n=10).X ray was carried out at 4 and12 weeks after surgery to evaluate fusion quality.The goats were killed respectively on the 12th week.Nondestructive biomechanical testing for stiffness,un-decalcified histology were performed.Result:The goats in the n-HA/PA66 with rhBMP-2 group and the autogrft group all showed complete fusion at 12th week.there was no statisti- cally significant differience between the n-HA/PA66 with rhBMP-2 group and the autogrft group upon biomechanics,radiography and histomorphology.Conclusion:The interverbral fusion cage with n-HA/PA66 has good hiocompatibifity and osteoconductive ability and it may be good osteoionductive with rhBMP-2,so it was one ideal interbody fusion cage.

0.05).CONCLUSION A similar MMN exists in guinea pigs and human.MMN has a process of development,differentiation and maturation with aging. Guinea pigs can serve as the candidate animal for MMN research.Comparing with ABR,MMN is more sensitive to evaluate the central auditory function.

0.05).Conclusion The intervertebral fusion cage of n-HA/PA66 has good biocompatibility and osteo-conductibility.It may be the ideal interbody fusion cage.

Objective To detect the serum proteomic patterns using SELDI-TOF-MS ProteinChip array technology in gastric cancer,screen biomarker candidates,build diagnostic models and evaluate its clinical significance in early gastric cancer.Methods SELDI-TOF-MS ProteinChip was used to detect the serum proteomic patterns of 40 patients with gastric cancer and 30 healthy people.The diagnostic models were developed and validated by discriminant analysis.Results The model composed by 3 protein peaks 8592m/z、13725m/z and 8678m/z could do the best in the diagnosis of gastric cancer.The specificity and sensitivity of it were 86.5%(26/30)and 90%(36/40)respectively.Conclusions This method show great potential for the early detection,staging before operation and screening novel and better biomarkers to early gastric cancer.

Objective To study the neuroelectrophysiological responsibility, mechanism and clinical application of auditory event-related potential (AERP) generated in bilateral auditory centers with ipsilateral and contralateral recordings. Methods 14 normal young adults were served as subjects. AERPs, including the responsibility, latencies, amplitudes and waveforms, were simultaneously recorded on ipsilateral and contralateral vertexes and analyzed. Results The latencies and amplitudes of AERPs did not show significicant difference statislically between ipsilateral and contralateral vertexes recordings. However, the responsibility of AERP recorded on ipsilateral vertex was more satisfied than that on contralateral vertex, which exhibited smoothing waves, discriminative wave peaks and little hetero-wave. Conclusion The origins of AERP in bilateral auditory centers were essentially symmetrical. Nevertheless, the responsibility of AERP recorded on ipsilateral vertex was more satisfied than that on contralateral vertex, which was related to the components of auditory subcortex, transmission of auditory nerve to bilateral centers and the contralateral inhibiting effect of medial olivo-cochlear system. The effects of multi-generation and multi-component of AERPs on the clinical application should be considered.