The posterior cruciate ligament(PCL) is one of the most important structures in the knee joing because it provides about 94% of the total restraint to posterior displacement of the tibia & posterior stability of the knee joint. If the posterior instability persisted, rotational instability, injury to meniscus and degenerative change develop within several years. The purpose of this study is to know the result of the posterior cruciate ligament reconstruction using semitendinosus tendon and to know the factors which affected to good result. During the period from January 1989 to December 1994, 16 cases with posterior cruciate ligament reconstruction using semitendinosus tendon were evaluated clinical and radiological results retrospectively and performed stastical analysis using the SPSS. The results were as follows; 1. The average preoperative posterior laxity was 14.1 mm and average postoperative laxity was 6.3 mm. It was improved 7.8 mm. 2. In other associated injured ligament group with or without fracture, above good was in 8 cases and below fair in 6 cases, but there was no significant difference between the two (X²=9.8, df=1, P>0.05). 3. In the poor result group, mean body weight was 80(±13.23)kg and there was significant difference between poor group & fair, good, excellent group(F=3.52, P < 0.05). From these results it would be suggested that PCL reconstruction using semitendinosus tendon is more effective in relatively light weighted group than heavier group.
Body Weight ; Knee ; Knee Joint ; Ligaments ; Posterior Cruciate Ligament ; Retrospective Studies ; Tendons ; Tibia

The influences of adrenal corticosteroid on the development and regression of neurons of dentate and hippocampus were studied by adrenalectomy and steroid overload in neonatal rats. The results obtained were as follows. 1. The cell death occurred naturally in numerous dentate granule cells and hippocampal pyramidal cells. 2. The number of dentate granule cells undergoing cell death decreased by injection of adrenal corticosteroid, but increased in adrenalectomized rat brains. The changes occurred prominently at postnatal day 6. 3. The number of hippocampal pyramidal cells undergoing cell death decreased in CA3 region by injection of adrenal corticosteroid, but was not changed in adrenalectomized rat brains. However, other regions exhibited no change by adrenal corticosteroid and adrenalectomy. 4. The cell death of pyramidal cells of CA3 region occurred in close relationship with the cell death of dentate granule cells, which was different from other CA regions. In summary, the cell death of dentate and hippocampal neurons occurred naturally but seemed to be influenced by other factors as well as adrenal corticosteroid.
Adrenalectomy ; Animals ; Brain ; Cell Death ; Hippocampus* ; Neurons* ; Pyramidal Cells ; Rats*

No abstract available.
Thanatophoric Dysplasia*

No abstract available.

OBJECTIVE: We examined the vasoconstricting poperties of endothelin (ET) on isolated arteries from pregnant as well as non-pregnant uterus. METHODS: Arteries of the uterus were obtained from both hysterectomized uterus and during pregnany hysterectomy for control group and cesarean section for pregnant group. Rings of uterine artery were suspended on muscle chambers at their optimal length for generating tension and contractile properties were examined. RESULTS: ET-1 and ET-2 induced concentration-dependent constriction of both isolated arterial strips from non-pregnant and pregnant uterus. The contraction to ET-1 and ET-2 were more enhanced in full-term pregnancy. Furthermore, in pregnant group, sarafotoxin S6c and IRL 1620, ET. agonists, induced a dose-dependent contraction, which was not shown in those from non-pregnant human. Pretreatment of human uterine arterial strips from pregnant uterus with BQ610, an ET. antagonist, for 10 min resulted in a dose-related rightward shift of ET-1 response curve with diminution of maximal response. Schild plot analysis yielded a pA value of 7.29 with a slope of 0.98. However, BQ788, an ET antagonist, did not produce any rightward shift. The contraction to lower concentration (10-8~3*10-7 M) of sarafotoxin S6c was not affected by BQ788, whereas that to higher concentration (10-s-8*10-7 M) was marked diminished. However, BQ610 did not exnt any efFect on sarafotoxin S6c-induced contraction in arterial staips from pregnant uterus. When the bath solution was replaced with Ca-free physiological salt solution (PSS) containing 1 mM EGTA for 10 min prior to adding sarafotoxin S6c, sarafotoxin S6c-induced contraction was completely abolished. Sarafotoxin S6c (10 nM)-induced contraction was prefetentially blocked by a protein kinase C antagonist, H-7, whereas it was less sensitive to a calmodulin antagonist, calmidazolium, CONCLUSION: Based on above results, we concluded that ET plays an important role in regulating uterine blood flow through the activation of ETa and ETB receptors. Furthermote, ETB receptors may predominantly contribute to the modulation of human uterine circulation in full-term pregnancy.
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine ; Arteries* ; Baths ; Calmodulin ; Cesarean Section ; Constriction ; Egtazic Acid ; Endothelin-2 ; Endothelins* ; Female ; Humans* ; Hysterectomy ; Pregnancy ; Protein Kinase C ; Receptors, Endothelin ; Uterine Artery ; Uterus*

No abstract available.
Follow-Up Studies* ; Knee*

Common peroneal nerve injury has been reported as the most frequent lower extremity peripheral nerve injury. The peroneal nerve may be particulary prone to direct or indirect injury by penetrating trauma or external compression by it's superficial route to bony prominence of fibular neck. By the development of microsurgical technique, recently epineural repair, fascicular group repair, and interfascicular graft were tried. The authors have experienced five cases microsurgical repair of common peroneal nerve injury around the knee joint from December 1990 to November 1991, and motor and sensory result was relatively good.
Knee Joint ; Lower Extremity ; Neck ; Peripheral Nerve Injuries ; Peroneal Nerve ; Transplants

The bipolar hemiarthroplasty is one of the treatment methods of the avascular necrosis of the femoral head and the fracture of the femur neck. The mechanism of bipolar hemiarthroplasty is intended to distribute the forces at the site of the inner and outer articulation, and theoritically diminish acetabular wear and produce a painless arthroplasty. The authors analyzed motion of two components in 23 cases of the bipolar hemiarthroplasty, performed at the Department of Orthopaedic Surgery, Korea University Hospital, between January, 1985 and January, 1993 with average 47 months follow up(range 24 to 84 months). The results obtained were as follows: 1. In the motion of the two components, inner bearing motion was average 11.5 degrees(from 1 to 29 degrees) and outer bearing motion was average 21.4 degrees(from 3 to 45 degrees). 2. The inner bearing motion was highest at 12 months with average 16 degrees and outer bearing motion was lowest during the same period with average 15 degrees. During the follow up the inner bearing motion was decreased whereas outer bearing motion was increased. 3. The inner or outer bearing motion of bipolar component was no correlation with age, sex and clinical result.
Acetabulum ; Arthroplasty ; Femur Neck ; Follow-Up Studies ; Head ; Hemiarthroplasty ; Korea ; Necrosis

Animals ; Body Weight ; Fluorouracil ; Hair ; Rats ; Rats, Sprague-Dawley

No abstract available.
Interferon-alpha* ; Interleukin-2* ; Killer Cells, Lymphokine-Activated*