No abstract available.
Fetal Blood* ; Humans ; Infant, Newborn* ; Phenotype

No abstract available.
Arm* ; Chromosomes, Human, Pair 14*

No abstract available.
Abortion, Habitual* ; Cytogenetics* ; Family Characteristics* ; Female ; Pregnancy

No abstract available.
Ring Chromosomes*

No abstract available.
Diagnosis* ; Hemophilia A* ; Molecular Biology* ; Polymorphism, Restriction Fragment Length*

Adriamycin has been widely used as an anticancer drug in the treatment of thyroid tumor, metastatic breast cancer, sarcoma and lymphoma. The antineoplastic effects of adriamycin result from its inhibitory action on the nucleic acid synthesis and the formation of reactive oxygen radicals by redoxcycling during its metabolic process. Adriamycin affects the normal cells of the patients and causes the undesirable side effects and the toxic effects. Thus, in this study we investigated the effect of dimethyl thiourea (DMTU), a hydroxyl radical scavenger, on the ultrastructural changes of the hepatocyte after the administration of adriamycin in the growing and adult rats. 36 Healthy male Sprague -Dawley adult rats (about 350 g) and 36 male rats at growing peroid (about 120 g) was used as experimental animals. Adriamycin (25 mg/kg) was administered intraperitoneally and DMTU (500 mg/kg) was administered intraperitoneally 30 minutes after the administration of adriamycin. The rats were sacrificed at 24 hours and 72 hours after the administration of adriamycin. A part of the liver from left anterior lobe was obtained and sliced into about 1 mm 3 . The specimens were prepared by the routine methods for electron microscopy. All preparations were stained with uranyl acetate and lead citrate and observed with Hitach -600 electron microscope. The results were as follows. 1. In the hepatocytes of the adult rat dilated, segmented and ribosome detached cisternae of rough endoplasmic reticulum, increased and dilated cisternae of smooth endoplasmic reticulum, damaged mitochondria and autophagic vacuoles were seen after the administration of adriamycin. The ultrastructural changes were progressive with the lapse of time. 2. In the hepatocyte of the growing rat dilated and ribosome detached cisternae of rough endoplasmic reticulum, changes of mitochondria, many lysosomes and the autophagic vacuoles were observed after the administration of adriamycin. 3. DMTU alone did not affect the ultrastructures of the hepatocytes in both growing and adult rats. 4. In the hepatocytes of growing and adult rats, dilated and ribosome detached cisternae of rough endoplasmic reticulum, dilated and increased cisternae of smooth endoplasmic reticulum, changes of mitochondria and autophagic vacuoles were seen after the combined administration of adriamycin and DMTU, but the degree of ultrastructural changes was
Adult* ; Animals ; Breast Neoplasms ; Citric Acid ; Doxorubicin* ; Endoplasmic Reticulum, Rough ; Endoplasmic Reticulum, Smooth ; Hepatocytes* ; Humans ; Hydroxyl Radical ; Liver ; Lymphoma ; Lysosomes ; Male ; Metabolism ; Microscopy, Electron ; Mitochondria ; Rats* ; Reactive Oxygen Species ; Ribosomes ; Sarcoma ; Thiourea ; Thyroid Gland ; Vacuoles

The authors describe a male newborn with multiple congenital anomalies; craniofacial dysmorphism, bilateral cleft palate and lip, ambiguous external genitalia with absence of phallus, ventricular septal defect, agenesis of olfactory bulbs, and presence of small round cells simulating migration defect in the cerebellar white matter. Cytogenetic study demonstrated a chromosomal constitution of 47,XY, +21, +5q. Its pathological significance compared with Down's syndrome and hitherto reported partial trisomy 5q is discussed.
Abnormalities, Multiple/*genetics/pathology ; *Chromosomes, Human, Pair 5 ; Down Syndrome/*genetics/pathology ; Humans ; Infant, Newborn ; Male ; Phenotype ; *Trisomy

OBJECTIVE: To investigate the therapeutic effect of neurologic music therapy (NMT) and speech language therapy (SLT) through improvement of the aphasia quotient (AQ) in post-stroke aphasic patients. METHODS: Twenty-one post-stroke, nonfluent aphasia patients who had ischemic/hemorrhagic stroke on radiologic evaluation were divided into the NMT and SLT groups. They received NMT and SLT for 1 month. Language function was assessed by Korean version-Western Aphasia Battery before and after therapy. NMT consisted of therapeutic singing and melodic intonation therapy, and SLT consisted of language-oriented therapy. RESULTS: Significant improvements were revealed in AQ, repetition, and naming after therapy in the NMT group and improvements in repetition in the SLT group of chronic stroke patients (p<0.05). There were significant improvements in language ability in the NMT group of subacute stroke patients. However, there was no significant improvement in the SLT group of subacute stroke patients. CONCLUSION: We concluded that the two therapies are effective treatments in the chronic stage of stroke and NMT is effective in subacute post-stroke aphasic patients.
Aphasia ; Aphasia, Broca ; Humans ; Language ; Language Therapy ; Music ; Music Therapy ; Singing ; Speech Therapy ; Stroke

BACKGROUND: Accurate knowledge of mainstem bronchial lengths are required to prevent malpositioning of double lumen endobronchial tubes (DLT). Therefore we evaluated the length of the mainstem bronchus in Korean adults who had no abnormalities in both mainstem bronchus. METHODS: Two-hundred Thirty-seven patients were composed of One-hundred one males and One- hundred Thirty-six females who underwent elective surgery. After an endotracheal tube was placed, we measured the length from the upper incisor to the tracheal carina, the right mainstem bronchial carina, and the left mainstem bronchial carina using a fiberoptic bronchoscope. RESULTS: The lengths from the upper incisor to the carina of a male and female were 26.8 +/- 1.8 cm and 23.6 +/- 1.9 cm respectively, and the correlations between their length and height are significant for male and female (r = 0.32, P < 0.01 and r = 0.56, p < 0.0001). The lengths from the upper incisor to the right mainstem bronchial carina of male and female were 29.0 2.0 cm and 25.3 2.2 cm respectively, and the correlations between their length and height are significant for male and female (r = 0.39, P < 0.0001 and r = 0.59, P < 0.0001). The lengths from the upper incisor to the left mainstem bronchial carina of male and female were 32.0 2.1 cm and 28.5 2.1 cm respectively, and the correlations between their length and height are significant for male and female (r = 0.45, P < 0.0001 and r = 0.60, P < 0.0001). CONCLUSIONS: We found that as the height of patients increased, the length from the upper incisor to the carina, the right mainstem bronchial carina, and the left mainstem bronchial carina increased. Nevertheless,it should be understood that the length of DLT insertion at any given height is still normally distributed, and correct DLT positioning should always be confirmed fiberoptically after the initial placement.
Adult* ; Bronchi ; Bronchoscopes* ; Female ; Humans ; Incisor* ; Male